Correlates of the Rate of Decline of CD4+ Lymphocytes among Injection Drug Users Infected with the Human Immunodeficiency Virus

@article{citeulike:1526781, abstract = {Changes in the level of CD4-bearing T-lymphocytes in injection drug users infected with the human immunodeficiency virus were evaluated in a sample of 318 subjects enrolled from a methadone program in the Bronx, New York, from 1985 through 1989. Follow-up continued through 1990. The percentage of CD4+ T-lymphocytes (CD4\%) was used to maximize the stability of measurements. The rate of decline of the CD4\% was determined using a random-effects assumption, and predictors of rate of decline were evaluated using an autoregressive model. The rate of CD4\% decline was approximately 1.2 CD4\% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4\% lost). The most important predictors of decline of the CD4\% in autoregressive models were current pyogenic bacterial infection (CD4\% reduced by 2.75, 95\% confidence interval (Cl) 0.42-5.08), current report of a second constitutional symptom (CD4\% reduced by 2.16, 95\% Cl 0.03-4.29), and history of bacterial infection (CD4\% reduced by 1.49, 95\% Cl 0.09-2.89; proportion of prior CD4\% lost increased by 0.14, 95\% Cl 0.01-0.27). Oral thrush was not related to an accelerated rate of CD4\% decline.}, author = {Alcabes, Philip and Schoenbaum, Ellie E. and Klein, Robert S. }, citeulike-article-id = {1526781}, journal = {Am. J. Epidemiol.}, keywords = {cd4, euresist, hiv, ivda}, month = {May}, number = {9}, pages = {989--1000}, posted-at = {2007-08-01 10:31:29}, priority = {2}, title = {Correlates of the Rate of Decline of CD4+ Lymphocytes among Injection Drug Users Infected with the Human Immunodeficiency Virus}, url = {http://aje.oxfordjournals.org/cgi/content/abstract/137/9/989}, volume = {137}, year = {1993} }

TY - JOUR ID - citeulike:1526781 L3 - citeulike-article-id:1526781 TI - Correlates of the Rate of Decline of CD4+ Lymphocytes among Injection Drug Users Infected with the Human Immunodeficiency Virus JF - Am. J. Epidemiol. VL - 137 IS - 9 SP - 989 EP - 1000 N2 - Changes in the level of CD4-bearing T-lymphocytes in injection drug users infected with the human immunodeficiency virus were evaluated in a sample of 318 subjects enrolled from a methadone program in the Bronx, New York, from 1985 through 1989. Follow-up continued through 1990. The percentage of CD4+ T-lymphocytes (CD4%) was used to maximize the stability of measurements. The rate of decline of the CD4% was determined using a random-effects assumption, and predictors of rate of decline were evaluated using an autoregressive model. The rate of CD4% decline was approximately 1.2 CD4% lost per 6 months, with a higher rate in recent seroconverters (2.2 CD4% lost). The most important predictors of decline of the CD4% in autoregressive models were current pyogenic bacterial infection (CD4% reduced by 2.75, 95% confidence interval (Cl) 0.42-5.08), current report of a second constitutional symptom (CD4% reduced by 2.16, 95% Cl 0.03-4.29), and history of bacterial infection (CD4% reduced by 1.49, 95% Cl 0.09-2.89; proportion of prior CD4% lost increased by 0.14, 95% Cl 0.01-0.27). Oral thrush was not related to an accelerated rate of CD4% decline. KW - cd4 KW - euresist KW - hiv KW - ivda AU - Alcabes, Philip AU - Schoenbaum, Ellie AU - Klein, Robert PY - 1993/05/01/ UR - http://aje.oxfordjournals.org/cgi/content/abstract/137/9/989 ER -