The Roles of MicroRNAs in Vertebrate Physiology and Human Disease.

@article{citeulike:1305549, abstract = {Over the last five years, the importance of a diverse class of 18-24 nucleotide RNA molecules known as microRNAs (miRNAs) has increasingly been recognized. These highly conserved RNAs regulate the stability and translational efficiency of complementary target messenger RNAs. The human genome is now believed to encode nearly 1000 miRNAs that likely regulate at least one-third of human transcripts. Despite rapid progress in miRNA discovery, the physiologic functions of only a relatively small number have been definitively established. In this review, we will discuss the principles of miRNA function in vertebrates that have emerged from the studies performed thus far. We will also present known and potential roles for miRNAs in human disease states and discuss the influence of human genetic variation on miRNA-mediated regulation. Expected online publication date for the Annual Review of Genomics and Human Genetics Volume 8 is August 30, 2007. Please see http://www.annualreviews.org/catalog/pub\_dates.asp for revised estimates.}, address = {The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 tchang12@jhmi.edu.}, author = {Chang, Tsung-Cheng C. and Mendell, Joshua T T. }, citeulike-article-id = {1305549}, doi = {http://dx.doi.org/10.1146/annurev.genom.8.080706.092351}, issn = {1527-8204}, journal = {Annu Rev Genomics Hum Genet}, keywords = {cancer, microrna, review}, month = {August}, posted-at = {2007-12-11 20:53:23}, priority = {0}, title = {The Roles of MicroRNAs in Vertebrate Physiology and Human Disease.}, url = {http://dx.doi.org/10.1146/annurev.genom.8.080706.092351}, year = {2006} }

TY - JOUR ID - citeulike:1305549 L3 - citeulike-article-id:1305549 TI - The Roles of MicroRNAs in Vertebrate Physiology and Human Disease. JF - Annu Rev Genomics Hum Genet AD - The McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205 tchang12@jhmi.edu. SN - 1527-8204 N2 - Over the last five years, the importance of a diverse class of 18-24 nucleotide RNA molecules known as microRNAs (miRNAs) has increasingly been recognized. These highly conserved RNAs regulate the stability and translational efficiency of complementary target messenger RNAs. The human genome is now believed to encode nearly 1000 miRNAs that likely regulate at least one-third of human transcripts. Despite rapid progress in miRNA discovery, the physiologic functions of only a relatively small number have been definitively established. In this review, we will discuss the principles of miRNA function in vertebrates that have emerged from the studies performed thus far. We will also present known and potential roles for miRNAs in human disease states and discuss the influence of human genetic variation on miRNA-mediated regulation. Expected online publication date for the Annual Review of Genomics and Human Genetics Volume 8 is August 30, 2007. Please see http://www.annualreviews.org/catalog/pub_dates.asp for revised estimates. KW - cancer KW - microrna KW - review AU - Chang, Tsung-Cheng AU - Mendell, Joshua T PY - 2006/08/14/ UR - http://dx.doi.org/10.1146/annurev.genom.8.080706.092351 ER -