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The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.

by: M Hucka, A Finney, HM Sauro, H Bolouri, JC Doyle, H Kitano, AP Arkin, BJ Bornstein, D Bray, A Cornish-Bowden, AA Cuellar, S Dronov, ED Gilles, M Ginkel, V Gor, II Goryanin, WJ Hedley, TC Hodgman, JH Hofmeyr, PJ Hunter, NS Juty, JL Kasberger, A Kremling, U Kummer, N Le Novère, LM Loew, D Lucio, P Mendes, E Minch, ED Mjolsness, Y Nakayama, MR Nelson, PF Nielsen, T Sakurada, JC Schaff, BE Shapiro, TS Shimizu, HD Spence, J Stelling, K Takahashi, M Tomita, J Wagner, J Wang
Bioinformatics, Vol. 19, No. 4. (1 March 2003), pp. 524-531.


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MOTIVATION: Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively. RESULTS: We summarize the Systems Biology Markup Language (SBML) Level 1, a free, open, XML-based format for representing biochemical reaction networks. SBML is a software-independent language for describing models common to research in many areas of computational biology, including cell signaling pathways, metabolic pathways, gene regulation, and others. AVAILABILITY: The specification of SBML Level 1 is freely available from http://www.sbml.org/


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