Histone replacement marks the boundaries of cis-regulatory domains.

@article{citeulike:1167961, abstract = {Cellular memory is maintained at homeotic genes by cis-regulatory elements whose mechanism of action is unknown. We have examined chromatin at Drosophila homeotic gene clusters by measuring, at high resolution, levels of histone replacement and nucleosome occupancy. Homeotic gene clusters display conspicuous peaks of histone replacement at boundaries of cis-regulatory domains superimposed over broad regions of low replacement. Peaks of histone replacement closely correspond to nuclease-hypersensitive sites, binding sites for Polycomb and trithorax group proteins, and sites of nucleosome depletion. Our results suggest the existence of a continuous process that disrupts nucleosomes and maintains accessibility of cis-regulatory elements.}, address = {Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.}, author = {Mito, Y. and Henikoff, J. G. and Henikoff, S. }, citeulike-article-id = {1167961}, doi = {http://dx.doi.org/10.1126/science.1134004}, issn = {1095-9203}, journal = {Science}, keywords = {cis\_regulatory\_elements, dynamics, eisen\_journal\_club, in\_depth\_suggestion, nucleosome, rich\_presented, round\_robin}, month = {March}, number = {5817}, pages = {1408--1411}, posted-at = {2007-03-16 20:42:42}, priority = {3}, title = {Histone replacement marks the boundaries of cis-regulatory domains.}, url = {http://dx.doi.org/10.1126/science.1134004}, volume = {315}, year = {2007} }

TY - JOUR ID - citeulike:1167961 L3 - citeulike-article-id:1167961 TI - Histone replacement marks the boundaries of cis-regulatory domains. JF - Science VL - 315 IS - 5817 SP - 1408 EP - 1411 AD - Basic Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. SN - 1095-9203 N2 - Cellular memory is maintained at homeotic genes by cis-regulatory elements whose mechanism of action is unknown. We have examined chromatin at Drosophila homeotic gene clusters by measuring, at high resolution, levels of histone replacement and nucleosome occupancy. Homeotic gene clusters display conspicuous peaks of histone replacement at boundaries of cis-regulatory domains superimposed over broad regions of low replacement. Peaks of histone replacement closely correspond to nuclease-hypersensitive sites, binding sites for Polycomb and trithorax group proteins, and sites of nucleosome depletion. Our results suggest the existence of a continuous process that disrupts nucleosomes and maintains accessibility of cis-regulatory elements. KW - cis_regulatory_elements KW - dynamics KW - eisen_journal_club KW - in_depth_suggestion KW - nucleosome KW - rich_presented KW - round_robin AU - Mito, Y AU - Henikoff, JG AU - Henikoff, S PY - 2007/03/09/ UR - http://dx.doi.org/10.1126/science.1134004 ER -