Overdispersion of the molecular clock varies between yeast, Drosophila and mammals

@article{citeulike:2839536, abstract = {Although protein evolution can be approximated as a "molecular evolutionary clock," it is well known that sequence change departs from a clock-like Poisson expectation. Through studying the deviations from a molecular clock, insight can be gained into the forces shaping evolution at the level of proteins. Generally, substitution patterns that show greater variance than the Poisson expectation are said to be "overdispersed." Overdispersion of sequence change may result from temporal variation in the rate at which amino acid substitutions occur on a phylogeny. By comparing the genomes of four species of yeast, five species of Drosophila and five species of mammals, we show that the extent of overdispersion shows a strong negative correlation with the effective population size of these organisms. Yeast proteins show very little overdispersion, while mammalian proteins show substantial overdispersion. Additionally, X-linked genes, which have reduced effective population size, have gene products that show increased overdispersion in both Drosophila and mammals. Our research suggests that mutational robustness is more pervasive in organisms with large population sizes, and that robustness acts to stabilize the molecular evolutionary clock of sequence change. 10.1534/genetics.108.089185}, author = {Bedford, Trevor and Wapinski, Ilan and Hartl, Daniel L. }, citeulike-article-id = {2839536}, doi = {http://dx.doi.org/10.1534/genetics.108.089185}, journal = {Genetics}, keywords = {fly, mammals, molclock, yeast}, month = {May}, pages = {genetics.108.089185+}, posted-at = {2008-05-28 16:38:50}, priority = {2}, title = {Overdispersion of the molecular clock varies between yeast, Drosophila and mammals}, url = {http://dx.doi.org/10.1534/genetics.108.089185}, year = {2008} }

TY - JOUR ID - citeulike:2839536 L3 - citeulike-article-id:2839536 TI - Overdispersion of the molecular clock varies between yeast, Drosophila and mammals JF - Genetics SP - genetics.108.089185 N2 - Although protein evolution can be approximated as a "molecular evolutionary clock," it is well known that sequence change departs from a clock-like Poisson expectation. Through studying the deviations from a molecular clock, insight can be gained into the forces shaping evolution at the level of proteins. Generally, substitution patterns that show greater variance than the Poisson expectation are said to be "overdispersed." Overdispersion of sequence change may result from temporal variation in the rate at which amino acid substitutions occur on a phylogeny. By comparing the genomes of four species of yeast, five species of Drosophila and five species of mammals, we show that the extent of overdispersion shows a strong negative correlation with the effective population size of these organisms. Yeast proteins show very little overdispersion, while mammalian proteins show substantial overdispersion. Additionally, X-linked genes, which have reduced effective population size, have gene products that show increased overdispersion in both Drosophila and mammals. Our research suggests that mutational robustness is more pervasive in organisms with large population sizes, and that robustness acts to stabilize the molecular evolutionary clock of sequence change. 10.1534/genetics.108.089185 KW - fly KW - mammals KW - molclock KW - yeast AU - Bedford, Trevor AU - Wapinski, Ilan AU - Hartl, Daniel PY - 2008/05/27/ UR - http://dx.doi.org/10.1534/genetics.108.089185 ER -