Self-consistent proteomic field theory of stochastic gene switches.

@article{citeulike:374350, abstract = {We present a self-consistent field approximation approach to the problem of the genetic switch composed of two mutually repressing/activating genes. The protein and DNA state dynamics are treated stochastically and on an equal footing. In this approach the mean influence of the proteomic cloud created by one gene on the action of another is self-consistently computed. Within this approximation a broad range of stochastic genetic switches may be solved exactly in terms of finding the probability distribution and its moments. A much larger class of problems, such as genetic networks and cascades, also remain exactly solvable with this approximation. We discuss, in depth, certain specific types of basic switches used by biological systems and compare their behavior to the expectation for a deterministic switch.}, address = {Department of Physics, Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California, USA.}, author = {Walczak, A. M. and Sasai, M. and Wolynes, P. G. }, citeulike-article-id = {374350}, doi = {10.1529/biophysj.104.050666}, issn = {0006-3495}, journal = {Biophys J}, keywords = {biophys, field-theory, gene, network, potein, stochast}, month = {February}, number = {2}, pages = {828--850}, posted-at = {2008-05-02 14:52:08}, priority = {2}, title = {Self-consistent proteomic field theory of stochastic gene switches.}, url = {http://dx.doi.org/10.1529/biophysj.104.050666}, volume = {88}, year = {2005} }

TY - JOUR ID - citeulike:374350 L3 - citeulike-article-id:374350 TI - Self-consistent proteomic field theory of stochastic gene switches. JF - Biophys J VL - 88 IS - 2 SP - 828 EP - 850 AD - Department of Physics, Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California, USA. SN - 0006-3495 N2 - We present a self-consistent field approximation approach to the problem of the genetic switch composed of two mutually repressing/activating genes. The protein and DNA state dynamics are treated stochastically and on an equal footing. In this approach the mean influence of the proteomic cloud created by one gene on the action of another is self-consistently computed. Within this approximation a broad range of stochastic genetic switches may be solved exactly in terms of finding the probability distribution and its moments. A much larger class of problems, such as genetic networks and cascades, also remain exactly solvable with this approximation. We discuss, in depth, certain specific types of basic switches used by biological systems and compare their behavior to the expectation for a deterministic switch. KW - biophys KW - field-theory KW - gene KW - network KW - potein KW - stochast AU - Walczak, AM AU - Sasai, M AU - Wolynes, PG PY - 2005/02// UR - http://dx.doi.org/10.1529/biophysj.104.050666 ER -