Transcriptional control of noise in gene expression

by: Alvaro Sanchez, Jane Kondev

Proceedings of the National Academy of Sciences (19 March 2008), 0707904105.

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Abstract

Cis-regulatory control of transcription is the dominant form of regulation of gene expression. Recent experimental results suggest that, in addition to the mean expression level, cell-to-cell variability might also be transcriptionally regulated. Here, we develop a stochastic model of transcriptional regulation that allows us to calculate closed-form analytical expressions for the mean and variance of the protein and mRNA distributions for an arbitrarily complex cis-regulatory motif. Our model allows us to investigate how noise may be transcriptionally regulated independently from the mean expression. We show that our approach is in excellent agreement with stochastic simulations and experiment, and leads to an experimentally testable formula for the noise in gene expression as a function of inducer-molecule concentrations. 10.1073/pnas.0707904105

@article{citeulike:2567082, abstract = {Cis-regulatory control of transcription is the dominant form of regulation of gene expression. Recent experimental results suggest that, in addition to the mean expression level, cell-to-cell variability might also be transcriptionally regulated. Here, we develop a stochastic model of transcriptional regulation that allows us to calculate closed-form analytical expressions for the mean and variance of the protein and mRNA distributions for an arbitrarily complex cis-regulatory motif. Our model allows us to investigate how noise may be transcriptionally regulated independently from the mean expression. We show that our approach is in excellent agreement with stochastic simulations and experiment, and leads to an experimentally testable formula for the noise in gene expression as a function of inducer-molecule concentrations. 10.1073/pnas.0707904105}, author = {Sanchez, Alvaro and Kondev, Jane }, citeulike-article-id = {2567082}, doi = {10.1073/pnas.0707904105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {biophys, gene, intrinsic-noise, network, transcription}, month = {March}, pages = {0707904105+}, posted-at = {2008-05-02 14:22:19}, priority = {2}, title = {Transcriptional control of noise in gene expression}, url = {http://dx.doi.org/10.1073/pnas.0707904105}, year = {2008} }

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TY - JOUR ID - citeulike:2567082 L3 - citeulike-article-id:2567082 TI - Transcriptional control of noise in gene expression JF - Proceedings of the National Academy of Sciences SP - 0707904105 N2 - Cis-regulatory control of transcription is the dominant form of regulation of gene expression. Recent experimental results suggest that, in addition to the mean expression level, cell-to-cell variability might also be transcriptionally regulated. Here, we develop a stochastic model of transcriptional regulation that allows us to calculate closed-form analytical expressions for the mean and variance of the protein and mRNA distributions for an arbitrarily complex cis-regulatory motif. Our model allows us to investigate how noise may be transcriptionally regulated independently from the mean expression. We show that our approach is in excellent agreement with stochastic simulations and experiment, and leads to an experimentally testable formula for the noise in gene expression as a function of inducer-molecule concentrations. 10.1073/pnas.0707904105 KW - biophys KW - gene KW - intrinsic-noise KW - network KW - transcription AU - Sanchez, Alvaro AU - Kondev, Jane PY - 2008/03/19/ UR - http://dx.doi.org/10.1073/pnas.0707904105 ER -

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