Dissociable Controlled Retrieval and Generalized Selection Mechanisms in Ventrolateral Prefrontal Cortex

@article{citeulike:331072, abstract = {SummaryHow does ventrolateral prefrontal cortex (VLPFC) control mnemonic processing? Alternative models propose that VLPFC guides top-down (controlled) retrieval of knowledge from long-term stores or selects goal-relevant products of retrieval from among competitors. A paucity of evidence supports a retrieval/selection distinction, raising the possibility that these models reduce to a common mechanism. Here, four manipulations varied semantic control demands during fMRI: judgment specificity, cue-target-associative strength, competitor dominance, and number of competitors. Factor analysis revealed evidence for a metafactor that accounted for common behavioral variance across manipulations and for functional variance in left mid-VLPFC. These data support a generalized control process that selects relevant knowledge from among competitors. By contrast, left anterior VLPFC and middle temporal cortex were sensitive to cue-target-associative strength, but not competition, consistent with a control process that retrieves knowledge stored in lateral temporal cortex. Distinct PFC mechanisms mediate top-down retrieval and postretrieval selection.}, author = {Badre, David and Poldrack, Russell A. and Par\&\#x00e9;-Blagoev, Juliana E. and Insler, Rachel Z. and Wagner, Anthony D. }, citeulike-article-id = {331072}, doi = {10.1016/j.neuron.2005.07.023}, journal = {Neuron}, keywords = {attention, controller, fmri, frontal, memory}, month = {September}, number = {6}, pages = {907--918}, posted-at = {2008-04-07 00:28:26}, priority = {2}, title = {Dissociable Controlled Retrieval and Generalized Selection Mechanisms in Ventrolateral Prefrontal Cortex}, url = {http://dx.doi.org/10.1016/j.neuron.2005.07.023}, volume = {47}, year = {2005} }

TY - JOUR ID - citeulike:331072 L3 - citeulike-article-id:331072 TI - Dissociable Controlled Retrieval and Generalized Selection Mechanisms in Ventrolateral Prefrontal Cortex JF - Neuron VL - 47 IS - 6 SP - 907 EP - 918 N2 - SummaryHow does ventrolateral prefrontal cortex (VLPFC) control mnemonic processing? Alternative models propose that VLPFC guides top-down (controlled) retrieval of knowledge from long-term stores or selects goal-relevant products of retrieval from among competitors. A paucity of evidence supports a retrieval/selection distinction, raising the possibility that these models reduce to a common mechanism. Here, four manipulations varied semantic control demands during fMRI: judgment specificity, cue-target-associative strength, competitor dominance, and number of competitors. Factor analysis revealed evidence for a metafactor that accounted for common behavioral variance across manipulations and for functional variance in left mid-VLPFC. These data support a generalized control process that selects relevant knowledge from among competitors. By contrast, left anterior VLPFC and middle temporal cortex were sensitive to cue-target-associative strength, but not competition, consistent with a control process that retrieves knowledge stored in lateral temporal cortex. Distinct PFC mechanisms mediate top-down retrieval and postretrieval selection. KW - attention KW - controller KW - fmri KW - frontal KW - memory AU - Badre, David AU - Poldrack, Russell AU - Paré-Blagoev, Juliana AU - Insler, Rachel AU - Wagner, Anthony PY - 2005/09/15/ UR - http://dx.doi.org/10.1016/j.neuron.2005.07.023 ER -