Convergence of Wnt, beta-catenin, and cadherin pathways.

by: WJ Nelson, R Nusse

Science, Vol. 303, No. 5663. (5 March 2004), pp. 1483-1487.

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Abstract

The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion.

@article{citeulike:1361135, abstract = {The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion.}, address = {Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. wjnelson@stanford.edu}, author = {Nelson, W. J. and Nusse, R. }, citeulike-article-id = {1361135}, doi = {10.1126/science.1094291}, issn = {1095-9203}, journal = {Science}, keywords = {b-catenin, wnt}, month = {March}, number = {5663}, pages = {1483--1487}, posted-at = {2007-06-04 00:22:52}, priority = {2}, title = {Convergence of Wnt, beta-catenin, and cadherin pathways.}, url = {http://dx.doi.org/10.1126/science.1094291}, volume = {303}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:1361135 L3 - citeulike-article-id:1361135 TI - Convergence of Wnt, beta-catenin, and cadherin pathways. JF - Science VL - 303 IS - 5663 SP - 1483 EP - 1487 AD - Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. wjnelson@stanford.edu SN - 1095-9203 N2 - The specification and proper arrangements of new cell types during tissue differentiation require the coordinated regulation of gene expression and precise interactions between neighboring cells. Of the many growth factors involved in these events, Wnts are particularly interesting regulators, because a key component of their signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration. Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion. KW - b-catenin KW - wnt AU - Nelson, WJ AU - Nusse, R PY - 2004/03/05/ UR - http://dx.doi.org/10.1126/science.1094291 ER -

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