Transgenesis upgrades for Drosophila melanogaster

by: Koen J Venken, Hugo J Bellen

Development, Vol. 134, No. 20. (15 October 2007), pp. 3571-3584.

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Abstract

Drosophila melanogaster is a highly attractive model system for the study of numerous biological questions pertaining to development, genetics, cell biology, neuroscience and disease. Until recently, our ability to manipulate flies genetically relied heavily on the transposon-mediated integration of DNA into fly embryos. However, in recent years significant improvements have been made to the transgenic techniques available in this organism, particularly with respect to integrating DNA at specific sites in the genome. These new approaches will greatly facilitate the structure-function analyses of Drosophila genes, will enhance the ease and speed with which flies can be manipulated, and should advance our understanding of biological processes during normal development and disease. 10.1242/dev.005686

@article{citeulike:1705428, abstract = {Drosophila melanogaster is a highly attractive model system for the study of numerous biological questions pertaining to development, genetics, cell biology, neuroscience and disease. Until recently, our ability to manipulate flies genetically relied heavily on the transposon-mediated integration of DNA into fly embryos. However, in recent years significant improvements have been made to the transgenic techniques available in this organism, particularly with respect to integrating DNA at specific sites in the genome. These new approaches will greatly facilitate the structure-function analyses of Drosophila genes, will enhance the ease and speed with which flies can be manipulated, and should advance our understanding of biological processes during normal development and disease. 10.1242/dev.005686}, author = {Venken, Koen J. and Bellen, Hugo J. }, citeulike-article-id = {1705428}, doi = {http://dx.doi.org/10.1242/dev.005686}, journal = {Development}, keywords = {drosophila, transposon}, month = {October}, number = {20}, pages = {3571--3584}, posted-at = {2008-07-03 13:58:43}, priority = {2}, title = {Transgenesis upgrades for Drosophila melanogaster}, url = {http://dx.doi.org/10.1242/dev.005686}, volume = {134}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1705428 L3 - citeulike-article-id:1705428 TI - Transgenesis upgrades for Drosophila melanogaster JF - Development VL - 134 IS - 20 SP - 3571 EP - 3584 N2 - Drosophila melanogaster is a highly attractive model system for the study of numerous biological questions pertaining to development, genetics, cell biology, neuroscience and disease. Until recently, our ability to manipulate flies genetically relied heavily on the transposon-mediated integration of DNA into fly embryos. However, in recent years significant improvements have been made to the transgenic techniques available in this organism, particularly with respect to integrating DNA at specific sites in the genome. These new approaches will greatly facilitate the structure-function analyses of Drosophila genes, will enhance the ease and speed with which flies can be manipulated, and should advance our understanding of biological processes during normal development and disease. 10.1242/dev.005686 KW - drosophila KW - transposon AU - Venken, Koen AU - Bellen, Hugo PY - 2007/10/15/ UR - http://dx.doi.org/10.1242/dev.005686 ER -

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