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Following translation by single ribosomes one codon at a time

by: Jin-Der Wen, Laura Lancaster, Courtney Hodges, Ana-Carolina Zeri, Shige H Yoshimura, Harry F Noller, Carlos Bustamante, Ignacio Tinoco
Nature (09 March 2008)

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of course... these "star" authors always produce excellent work, and this is no exception. More bang, wow.. OMG! than anything else. Ribosomes pause (we knew this) and the duration of pausing depends on RNA structure (we knew this too). Pausing can last from ≤0.1 seconds to as long as several minutes (didn't know that, i wonder if this is true in vivo), and translocations are a multi-step process that proceeds codon by codon, with a pause between each (we could have guessed that, but they pretty much nail this one). The big win with this paper is the technique. Although it's an extension of a previous paper using a molecular tweezers from Tinoco (in nature too i think), the addition of ribosomes (or any molecular machine for that matter) makes this just simply super cool circus fun awesome... a must read. 5 stars

Reviewed by jonathanjacobs as - 2008-04-04 21:57:54

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