The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae

@article{citeulike:2288327, abstract = {The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli. 10.1126/science.1151582}, author = {Mettetal, Jerome T. and Muzzey, Dale and Gomez-Uribe, Carlos and van Oudenaarden, Alexander }, citeulike-article-id = {2288327}, comment = {> To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis.}, doi = {http://dx.doi.org/10.1126/science.1151582}, journal = {Science}, keywords = {adaptation, clip2, network}, month = {January}, number = {5862}, pages = {482--484}, posted-at = {2008-02-12 09:41:39}, priority = {2}, title = {The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae}, url = {http://dx.doi.org/10.1126/science.1151582}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2288327 L3 - citeulike-article-id:2288327 TI - The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae JF - Science VL - 319 IS - 5862 SP - 482 EP - 484 N2 - The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli. 10.1126/science.1151582 KW - adaptation KW - clip2 KW - network N1 - > To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae. We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. AU - Mettetal, Jerome AU - Muzzey, Dale AU - Gomez-Uribe, Carlos AU - van Oudenaarden, Alexander PY - 2008/01/25/ UR - http://dx.doi.org/10.1126/science.1151582 ER -