Zoomed Functional Imaging in the Human Brain at 7 Tesla with Simultaneous High Spatial and High Temporal Resolution

@article{citeulike:2764708, abstract = {Functional neuroimaging in the human brain using noninvasive magnetic resonance methods has the potential of providing highly resolved maps of neuronal activation. Decreasing the voxel size and obtaining simultaneously high temporal resolution is a major challenge and is mainly limited by sensitivity. Here, signal-to-noise gains at high magnetic fields (7 Tesla) and an optimized surface coil setup are combined with a novel approach for zoomed functional imaging in the visual cortex. For echoplanar imaging, the acquisition time and segmentation was shortened fourfold by using a reduced field-of-view. An adiabatic outer-volume suppression method, BISTRO, was used to obliterate signal outside the area-of-interest achieving effective suppression even for inhomogeneous B1-fields. A single-shot acquisition was performed at submillimeter resolution in the human brain, while simultaneously maintaining a high temporal resolution of 125 ms. Functional studies with and without field-of-view reduction were performed. Activation and percent change maps were compared with respect to spatial extent, t values and percentage changes of the BOLD contrast. The detection of functional activation was found to be equal within the inter-series variability for the two acquisition schemes. Thus, single-trial BOLD responses were detected for the first time robustly at a 500 × 500 [mu]m2 in plane and 250 ms temporal resolution, significantly expanding the possibilities of event-related functional imaging in the human brain. The magnetization transfer effect induced by the outer-volume suppression pulses was investigated and found to be increased during neuronal activity.}, author = {Pfeuffer, Josef and van de Moortele, Pierre-Francois and Yacoub, Essa and Shmuel, Amir and Adriany, Gregor and Andersen, Peter and Merkle, Hellmut and Garwood, Michael and Ugurbil, Kamil and Hu, Xiaoping }, citeulike-article-id = {2764708}, doi = {http://dx.doi.org/10.1006/nimg.2002.1103}, journal = {NeuroImage}, month = {September}, number = {1}, pages = {272--286}, posted-at = {2008-05-07 12:33:49}, priority = {2}, title = {Zoomed Functional Imaging in the Human Brain at 7 Tesla with Simultaneous High Spatial and High Temporal Resolution}, url = {http://dx.doi.org/10.1006/nimg.2002.1103}, volume = {17}, year = {2002} }

TY - JOUR ID - citeulike:2764708 L3 - citeulike-article-id:2764708 TI - Zoomed Functional Imaging in the Human Brain at 7 Tesla with Simultaneous High Spatial and High Temporal Resolution JF - NeuroImage VL - 17 IS - 1 SP - 272 EP - 286 N2 - Functional neuroimaging in the human brain using noninvasive magnetic resonance methods has the potential of providing highly resolved maps of neuronal activation. Decreasing the voxel size and obtaining simultaneously high temporal resolution is a major challenge and is mainly limited by sensitivity. Here, signal-to-noise gains at high magnetic fields (7 Tesla) and an optimized surface coil setup are combined with a novel approach for zoomed functional imaging in the visual cortex. For echoplanar imaging, the acquisition time and segmentation was shortened fourfold by using a reduced field-of-view. An adiabatic outer-volume suppression method, BISTRO, was used to obliterate signal outside the area-of-interest achieving effective suppression even for inhomogeneous B1-fields. A single-shot acquisition was performed at submillimeter resolution in the human brain, while simultaneously maintaining a high temporal resolution of 125 ms. Functional studies with and without field-of-view reduction were performed. Activation and percent change maps were compared with respect to spatial extent, t values and percentage changes of the BOLD contrast. The detection of functional activation was found to be equal within the inter-series variability for the two acquisition schemes. Thus, single-trial BOLD responses were detected for the first time robustly at a 500 × 500 [mu]m2 in plane and 250 ms temporal resolution, significantly expanding the possibilities of event-related functional imaging in the human brain. The magnetization transfer effect induced by the outer-volume suppression pulses was investigated and found to be increased during neuronal activity. AU - Pfeuffer, Josef AU - van de Moortele, Pierre-Francois AU - Yacoub, Essa AU - Shmuel, Amir AU - Adriany, Gregor AU - Andersen, Peter AU - Merkle, Hellmut AU - Garwood, Michael AU - Ugurbil, Kamil AU - Hu, Xiaoping PY - 2002/09// UR - http://dx.doi.org/10.1006/nimg.2002.1103 ER -