Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

@article{citeulike:3019199, abstract = {Recent work suggests that farnesyltransferase inhibitors suppress cancer cell proliferation through mechanisms other than inhibiting Ras isoprenylation, which is not a crucial event. Recent evidence also suggests that the antineoplastic properties of farnesyltransferase inhibitors are due to alterations in the isoprenylation of RhoB, an endosomal Rho protein that functions in receptor trafficking. A shift in conceptual focus from Ras to Rho to understand how farnesyltransferase inhibitors act provides a new vantage to address old questions in the field and suggests strategies to improve and potentially widen clinical applications.}, author = {Prendergast, George C. }, citeulike-article-id = {3019199}, doi = {http://dx.doi.org/10.1016/S0955-0674(99)00072-1}, journal = {Current Opinion in Cell Biology}, keywords = {farnesyltransferase, ras, review}, month = {April}, number = {2}, pages = {166--173}, posted-at = {2008-07-18 19:29:39}, priority = {0}, title = {Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects}, url = {http://dx.doi.org/10.1016/S0955-0674(99)00072-1}, volume = {12}, year = {2000} }

TY - JOUR ID - citeulike:3019199 L3 - citeulike-article-id:3019199 TI - Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects JF - Current Opinion in Cell Biology VL - 12 IS - 2 SP - 166 EP - 173 N2 - Recent work suggests that farnesyltransferase inhibitors suppress cancer cell proliferation through mechanisms other than inhibiting Ras isoprenylation, which is not a crucial event. Recent evidence also suggests that the antineoplastic properties of farnesyltransferase inhibitors are due to alterations in the isoprenylation of RhoB, an endosomal Rho protein that functions in receptor trafficking. A shift in conceptual focus from Ras to Rho to understand how farnesyltransferase inhibitors act provides a new vantage to address old questions in the field and suggests strategies to improve and potentially widen clinical applications. KW - farnesyltransferase KW - ras KW - review AU - Prendergast, George PY - 2000/04/01/ UR - http://dx.doi.org/10.1016/S0955-0674(99)00072-1 ER -