The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa.

@article{citeulike:2988015, abstract = {Mucoid strains of Pseudomonas aeruginosa isolated from the lungs of cystic fibrosis patients produce large amounts of the exopolysaccharide alginate. AlgR has long been considered a key regulator of alginate production, but its cognate sensor has not been identified. Here we show that AlgR is required for twitching motility, which is a form of bacterial surface translocation mediated by type 4 fimbriae. Adjacent to algR we have identified a sensor gene (fimS), which is also required for twitching motility. However, FimS does not appear to be required for alginate production in mucoid strains. FimS and AlgR are representative of a new subclass of two-component transmitter-receiver regulatory systems. The alternative sigma factor AlgU also affects both alginate production and twitching motility. Therefore, these two virulence determinants appear to be closely associated and coordinately regulated.}, address = {Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.}, author = {Whitchurch, C. B. and Alm, R. A. and Mattick, J. S. }, citeulike-article-id = {2988015}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {aeruginosa, alginate, algr}, month = {September}, number = {18}, pages = {9839--9843}, posted-at = {2008-07-11 12:32:38}, priority = {2}, title = {The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8790418}, volume = {93}, year = {1996} }

TY - JOUR ID - citeulike:2988015 L3 - citeulike-article-id:2988015 TI - The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa. JF - Proceedings of the National Academy of Sciences of the United States of America VL - 93 IS - 18 SP - 9839 EP - 9843 AD - Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia. SN - 0027-8424 N2 - Mucoid strains of Pseudomonas aeruginosa isolated from the lungs of cystic fibrosis patients produce large amounts of the exopolysaccharide alginate. AlgR has long been considered a key regulator of alginate production, but its cognate sensor has not been identified. Here we show that AlgR is required for twitching motility, which is a form of bacterial surface translocation mediated by type 4 fimbriae. Adjacent to algR we have identified a sensor gene (fimS), which is also required for twitching motility. However, FimS does not appear to be required for alginate production in mucoid strains. FimS and AlgR are representative of a new subclass of two-component transmitter-receiver regulatory systems. The alternative sigma factor AlgU also affects both alginate production and twitching motility. Therefore, these two virulence determinants appear to be closely associated and coordinately regulated. KW - aeruginosa KW - alginate KW - algr AU - Whitchurch, CB AU - Alm, RA AU - Mattick, JS PY - 1996/09/03/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8790418 ER -