Pseudomonas aeruginosa forms biofilms in acute infection independent of cell-to-cell signaling.

@article{citeulike:2987399, abstract = {Biofilms are bacterial communities residing within a polysaccharide matrix that are associated with persistence and antibiotic resistance in chronic infections. We show that the opportunistic pathogen Pseudomonas aeruginosa forms biofilms within 8 h of infection in thermally injured mice, demonstrating that biofilms contribute to bacterial colonization in acute infections as well. Using light, electron, and confocal scanning laser microscopy, P. aeruginosa biofilms were visualized within burned tissue surrounding blood vessels and adipose cells. Although quorum sensing (QS), a bacterial signaling mechanism, coordinates differentiation of biofilms in vitro, wild-type and QS-deficient P. aeruginosa strains formed similar biofilms in vivo. Our findings demonstrate that P. aeruginosa forms biofilms on specific host tissues independently of QS.}, address = {Texas Tech University Health Sciences Center, Department of Surgery, 3601 4th Street, Lubbock, TX 79430, USA.}, author = {Schaber, J. A. and Triffo, W. J. and Suh, S. J. and Oliver, J. W. and Hastert, M. C. and Griswold, J. A. and Auer, M. and Hamood, A. N. and Rumbaugh, K. P. }, citeulike-article-id = {2987399}, doi = {http://dx.doi.org/10.1128/IAI.00586-07}, issn = {0019-9567}, journal = {Infection and immunity}, keywords = {aeruginosa, biofilm, burn, qs}, month = {August}, number = {8}, pages = {3715--3721}, posted-at = {2008-07-11 10:27:52}, priority = {2}, title = {Pseudomonas aeruginosa forms biofilms in acute infection independent of cell-to-cell signaling.}, url = {http://dx.doi.org/10.1128/IAI.00586-07}, volume = {75}, year = {2007} }

TY - JOUR ID - citeulike:2987399 L3 - citeulike-article-id:2987399 TI - Pseudomonas aeruginosa forms biofilms in acute infection independent of cell-to-cell signaling. JF - Infection and immunity VL - 75 IS - 8 SP - 3715 EP - 3721 AD - Texas Tech University Health Sciences Center, Department of Surgery, 3601 4th Street, Lubbock, TX 79430, USA. SN - 0019-9567 N2 - Biofilms are bacterial communities residing within a polysaccharide matrix that are associated with persistence and antibiotic resistance in chronic infections. We show that the opportunistic pathogen Pseudomonas aeruginosa forms biofilms within 8 h of infection in thermally injured mice, demonstrating that biofilms contribute to bacterial colonization in acute infections as well. Using light, electron, and confocal scanning laser microscopy, P. aeruginosa biofilms were visualized within burned tissue surrounding blood vessels and adipose cells. Although quorum sensing (QS), a bacterial signaling mechanism, coordinates differentiation of biofilms in vitro, wild-type and QS-deficient P. aeruginosa strains formed similar biofilms in vivo. Our findings demonstrate that P. aeruginosa forms biofilms on specific host tissues independently of QS. KW - aeruginosa KW - biofilm KW - burn KW - qs AU - Schaber, JA AU - Triffo, WJ AU - Suh, SJ AU - Oliver, JW AU - Hastert, MC AU - Griswold, JA AU - Auer, M AU - Hamood, AN AU - Rumbaugh, KP PY - 2007/08// UR - http://dx.doi.org/10.1128/IAI.00586-07 ER -