The Chromosomal Polymorphism Linked to Variation in Social Behavior in the White-Throated Sparrow (Zonotrichia albicollis) Is a Complex Rearrangement and Suppressor of Recombination

@article{citeulike:3037480, abstract = {Variation in social behavior and plumage in the white-throated sparrow (Zonotrichia albicollis) is linked to an inversion polymorphism on chromosome 2. Here we report the results of our comparative cytogenetic mapping efforts and population genetics studies focused on the genomic characterization of this balanced chromosomal polymorphism. Comparative chromosome painting and cytogenetic mapping of 15 zebra finch BAC clones to the standard (ZAL2) and alternative (ZAL2m) arrangements revealed that this chromosome is orthologous to chicken chromosome 3, and that at a minimum, ZAL2 and ZAL2m differ by a pair of included pericentric inversions that we estimate span at least 98 Mb. Population-based sequencing and genotyping of multiple loci demonstrated that ZAL2m suppresses recombination in the heterokaryotype and is evolving as a rare nonrecombining autosomal segment of the genome. In addition, we estimate that the first inversion within the ZAL2m arrangement originated 2.2 {+/-} 0.3 million years ago. Finally, while previously recognized as a genetic model for the evolution of social behavior, we found that the ZAL2/ZAL2m polymorphism also shares genetic and phenotypic features with the mouse t complex and we further suggest that the ZAL2/ZAL2m polymorphism is a heretofore unrecognized model for the early stages of sex chromosome evolution. 10.1534/genetics.108.088229}, author = {Thomas, James W. and Caceres, Mario and Lowman, Joshua J. and Morehouse, Caroline B. and Short, Meghan E. and Baldwin, Erin L. and Maney, Donna L. and Martin, Christa L. }, citeulike-article-id = {3037480}, doi = {http://dx.doi.org/10.1534/genetics.108.088229}, journal = {Genetics}, keywords = {chromosome, evolution, rearrangement, thomas}, month = {July}, number = {3}, pages = {1455--1468}, posted-at = {2008-07-23 19:11:43}, priority = {2}, title = {The Chromosomal Polymorphism Linked to Variation in Social Behavior in the White-Throated Sparrow (Zonotrichia albicollis) Is a Complex Rearrangement and Suppressor of Recombination}, url = {http://dx.doi.org/10.1534/genetics.108.088229}, volume = {179}, year = {2008} }

TY - JOUR ID - citeulike:3037480 L3 - citeulike-article-id:3037480 TI - The Chromosomal Polymorphism Linked to Variation in Social Behavior in the White-Throated Sparrow (Zonotrichia albicollis) Is a Complex Rearrangement and Suppressor of Recombination JF - Genetics VL - 179 IS - 3 SP - 1455 EP - 1468 N2 - Variation in social behavior and plumage in the white-throated sparrow (Zonotrichia albicollis) is linked to an inversion polymorphism on chromosome 2. Here we report the results of our comparative cytogenetic mapping efforts and population genetics studies focused on the genomic characterization of this balanced chromosomal polymorphism. Comparative chromosome painting and cytogenetic mapping of 15 zebra finch BAC clones to the standard (ZAL2) and alternative (ZAL2m) arrangements revealed that this chromosome is orthologous to chicken chromosome 3, and that at a minimum, ZAL2 and ZAL2m differ by a pair of included pericentric inversions that we estimate span at least 98 Mb. Population-based sequencing and genotyping of multiple loci demonstrated that ZAL2m suppresses recombination in the heterokaryotype and is evolving as a rare nonrecombining autosomal segment of the genome. In addition, we estimate that the first inversion within the ZAL2m arrangement originated 2.2 {+/-} 0.3 million years ago. Finally, while previously recognized as a genetic model for the evolution of social behavior, we found that the ZAL2/ZAL2m polymorphism also shares genetic and phenotypic features with the mouse t complex and we further suggest that the ZAL2/ZAL2m polymorphism is a heretofore unrecognized model for the early stages of sex chromosome evolution. 10.1534/genetics.108.088229 KW - chromosome KW - evolution KW - rearrangement KW - thomas AU - Thomas, James AU - Caceres, Mario AU - Lowman, Joshua AU - Morehouse, Caroline AU - Short, Meghan AU - Baldwin, Erin AU - Maney, Donna AU - Martin, Christa PY - 2008/07/01/ UR - http://dx.doi.org/10.1534/genetics.108.088229 ER -