Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories.

@article{Quinn2008, abstract = {Retrograde amnesia following disruptions of hippocampal function is often temporally graded, with recent memories being more impaired. Evidence supports the existence of one or more neocortical long-term memory storage/retrieval site(s). Neurotoxic lesions of the medial prefrontal cortex (mPFC) or the dorsal hippocampus (DH) were made 1 day or 200 days following trace fear conditioning. Recently encoded trace fear memories were most disrupted by DH lesions, while remotely encoded trace and contextual memories were most disrupted by mPFC lesions. These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval.}, address = {Department of Psychology and Brain Research Institute, UCLA, Los Angeles, California 90095-1563, USA.}, author = {Quinn, J. J. and Ma, Q. D. and Tinsley, M. R. and Koch, C. and Fanselow, M. S. }, citeulike-article-id = {2760259}, doi = {10.1101/lm.813608}, issn = {1549-5485}, journal = {Learning \& memory (Cold Spring Harbor, N.Y.)}, keywords = {consolidation, hippocampus, pfc}, number = {5}, pages = {368--372}, posted-at = {2008-05-06 10:02:37}, priority = {2}, title = {Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories.}, url = {http://dx.doi.org/10.1101/lm.813608}, volume = {15}, year = {2008} }

TY - JOUR ID - Quinn2008 L3 - citeulike-article-id:2760259 TI - Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories. JF - Learning & memory (Cold Spring Harbor, N.Y.) VL - 15 IS - 5 SP - 368 EP - 372 AD - Department of Psychology and Brain Research Institute, UCLA, Los Angeles, California 90095-1563, USA. SN - 1549-5485 N2 - Retrograde amnesia following disruptions of hippocampal function is often temporally graded, with recent memories being more impaired. Evidence supports the existence of one or more neocortical long-term memory storage/retrieval site(s). Neurotoxic lesions of the medial prefrontal cortex (mPFC) or the dorsal hippocampus (DH) were made 1 day or 200 days following trace fear conditioning. Recently encoded trace fear memories were most disrupted by DH lesions, while remotely encoded trace and contextual memories were most disrupted by mPFC lesions. These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval. KW - consolidation KW - hippocampus KW - pfc AU - Quinn, JJ AU - Ma, QD AU - Tinsley, MR AU - Koch, C AU - Fanselow, MS PY - 2008/// UR - http://dx.doi.org/10.1101/lm.813608 ER -