Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhythm.

@article{citeulike:2211976, abstract = {Theta phase-locking and phase precession are two related phenomena reflecting coordination of hippocampal place cell firing with the local, ongoing theta rhythm. The mechanisms and functions of both the phenomena remain unclear, though the robust correlation between firing phase and location of the animal has lead to the suggestion that this phase relationship constitutes a temporal code for spatial information. Recent work has described theta phase-locking in the rat medial prefrontal cortex (mPFC), a structure with direct anatomical and functional links to the hippocampus. Here, we describe an initial characterization of phase precession in the mPFC relative to the CA1 theta rhythm. mPFC phase precession was most robust during behavioral epochs known to be associated with enhanced theta-frequency coordination of CA1 and mPFC activities. Precession was coherent across the mPFC population, with multiple neurons precessing in parallel as a function of location of the animal. The existence of phase precession beyond the hippocampus implies a more global role for this phenomenon during theta rhythm-mediated coordination of neural activity.}, address = {Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, 02139, USA.}, author = {Jones, M. W. and Wilson, M. A. }, citeulike-article-id = {2211976}, doi = {http://dx.doi.org/10.1002/hipo.20119}, issn = {1050-9631}, journal = {Hippocampus}, keywords = {pfc, phaseprecession, theta}, number = {7}, pages = {867--873}, posted-at = {2008-01-09 20:00:05}, priority = {2}, title = {Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhythm.}, url = {http://dx.doi.org/10.1002/hipo.20119}, volume = {15}, year = {2005} }

TY - JOUR ID - citeulike:2211976 L3 - citeulike-article-id:2211976 TI - Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhythm. JF - Hippocampus VL - 15 IS - 7 SP - 867 EP - 873 AD - Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, 02139, USA. SN - 1050-9631 N2 - Theta phase-locking and phase precession are two related phenomena reflecting coordination of hippocampal place cell firing with the local, ongoing theta rhythm. The mechanisms and functions of both the phenomena remain unclear, though the robust correlation between firing phase and location of the animal has lead to the suggestion that this phase relationship constitutes a temporal code for spatial information. Recent work has described theta phase-locking in the rat medial prefrontal cortex (mPFC), a structure with direct anatomical and functional links to the hippocampus. Here, we describe an initial characterization of phase precession in the mPFC relative to the CA1 theta rhythm. mPFC phase precession was most robust during behavioral epochs known to be associated with enhanced theta-frequency coordination of CA1 and mPFC activities. Precession was coherent across the mPFC population, with multiple neurons precessing in parallel as a function of location of the animal. The existence of phase precession beyond the hippocampus implies a more global role for this phenomenon during theta rhythm-mediated coordination of neural activity. KW - pfc KW - phaseprecession KW - theta AU - Jones, MW AU - Wilson, MA PY - 2005/// UR - http://dx.doi.org/10.1002/hipo.20119 ER -