Diversity of microRNAs in human and chimpanzee brain.

by: Eugene Berezikov, Fritz Thuemmler, Linda W W van Laake, Ivanela Kondova, Ronald Bontrop, Edwin Cuppen, Ronald H A H Plasterk

Nat Genet (29 October 2006)

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Abstract

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

@article{citeulike:921343, abstract = {We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.}, address = {Hubrecht Laboratory–KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.}, author = {Berezikov, Eugene and Thuemmler, Fritz and van Laake, Linda W W. and Kondova, Ivanela and Bontrop, Ronald and Cuppen, Edwin and Plasterk, Ronald H A H. }, citeulike-article-id = {921343}, doi = {10.1038/ng1914}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {454, brain, chimpanzee, human, mirna}, month = {October}, posted-at = {2006-11-23 20:48:51}, priority = {4}, title = {Diversity of microRNAs in human and chimpanzee brain.}, url = {http://dx.doi.org/10.1038/ng1914}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:921343 L3 - citeulike-article-id:921343 TI - Diversity of microRNAs in human and chimpanzee brain. JF - Nat Genet AD - Hubrecht Laboratory–KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. SN - 1061-4036 N2 - We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs. KW - 454 KW - brain KW - chimpanzee KW - human KW - mirna AU - Berezikov, Eugene AU - Thuemmler, Fritz AU - van Laake, Linda W AU - Kondova, Ivanela AU - Bontrop, Ronald AU - Cuppen, Edwin AU - Plasterk, Ronald H A PY - 2006/10/29/ UR - http://dx.doi.org/10.1038/ng1914 ER -

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