The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.

@article{citeulike:1751007, abstract = {We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.}, address = {Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.}, author = {Cuomo, C. A. and G\"{u}ldener, U. and Xu, J. R. and Trail, F. and Turgeon, B. G. and Di Pietro, A. and Walton, J. D. and Ma, L. J. and Baker, S. E. and Rep, M. and Adam, G. and Antoniw, J. and Baldwin, T. and Calvo, S. and Chang, Y. L. and Decaprio, D. and Gale, L. R. and Gnerre, S. and Goswami, R. S. and Hammond-Kosack, K. and Harris, L. J. and Hilburn, K. and Kennell, J. C. and Kroken, S. and Magnuson, J. K. and Mannhaupt, G. and Mauceli, E. and Mewes, H. W. and Mitterbauer, R. and Muehlbauer, G. and M\"{u}nsterk\"{o}tter, M. and Nelson, D. and O'donnell, K. and Ouellet, T. and Qi, W. and Quesneville, H. and Roncero, M. I. and Seong, K. Y. and Tetko, I. V. and Urban, M. and Waalwijk, C. and Ward, T. J. and Yao, J. and Birren, B. W. and Kistler, H. C. }, citeulike-article-id = {1751007}, doi = {10.1126/science.1143708}, issn = {1095-9203}, journal = {Science}, keywords = {fungi}, month = {September}, number = {5843}, pages = {1400--1402}, posted-at = {2007-10-10 18:37:41}, priority = {2}, title = {The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization.}, url = {http://dx.doi.org/10.1126/science.1143708}, volume = {317}, year = {2007} }

TY - JOUR ID - citeulike:1751007 L3 - citeulike-article-id:1751007 TI - The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. JF - Science VL - 317 IS - 5843 SP - 1400 EP - 1402 AD - Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA. SN - 1095-9203 N2 - We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts. KW - fungi AU - Cuomo, CA AU - Güldener, U AU - Xu, JR AU - Trail, F AU - Turgeon, BG AU - Di Pietro, A AU - Walton, JD AU - Ma, LJ AU - Baker, SE AU - Rep, M AU - Adam, G AU - Antoniw, J AU - Baldwin, T AU - Calvo, S AU - Chang, YL AU - Decaprio, D AU - Gale, LR AU - Gnerre, S AU - Goswami, RS AU - Hammond-Kosack, K AU - Harris, LJ AU - Hilburn, K AU - Kennell, JC AU - Kroken, S AU - Magnuson, JK AU - Mannhaupt, G AU - Mauceli, E AU - Mewes, HW AU - Mitterbauer, R AU - Muehlbauer, G AU - Münsterkötter, M AU - Nelson, D AU - O'donnell, K AU - Ouellet, T AU - Qi, W AU - Quesneville, H AU - Roncero, MI AU - Seong, KY AU - Tetko, IV AU - Urban, M AU - Waalwijk, C AU - Ward, TJ AU - Yao, J AU - Birren, BW AU - Kistler, HC PY - 2007/09/07/ UR - http://dx.doi.org/10.1126/science.1143708 ER -