Hemodynamic response to visual stimulation in newborn infants using functional near-infrared spectroscopy.

@article{citeulike:2698831, abstract = {Brain activity is associated with physiological changes, which alter the optical properties of tissue. These changes can be detected by near-infrared spectroscopy (NIRS). Aim of the study was to determine changes in cerebral oxygenation in response to stimulation in the visual cortex in newborn infants during spontaneous sleep in the first days of life. We used an in-house developed multichannel NIRS imaging instrument, the MCP-II, to measure changes in concentration of oxyhemoglobin (O(2)Hb) and deoxyhemoglobin (HHb) in specific brain areas. In 10 out of 15 subjects, a significant increase in O(2)Hb and/or a significant decrease in HHb were found in one or more channels over the occipital cortex. During stimulation, O(2)Hb increased by a mean of 0.98 mumol/l, HHb decreased by a mean 0.17 mumol/l, and total-Hb increased by a mean of 0.81 mumol/l. The hemodynamic response to visual stimulation in the occipital cortex in newborn infants is similar to adults. The increase in O(2)Hb and the simultaneous decrease in HHb during stimulation suggest an increase in cerebral blood flow (CBF) that overcompensates for the increased oxygen consumption (CMRO(2)) in the activated cortical area. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc.}, address = {Clinic of Neonatology, University Hospital Zurich, Switzerland.}, author = {Karen, T. and Morren, G. and Haensse, D. and Bauschatz, A. S. and Bucher, H. U. and Wolf, M. }, citeulike-article-id = {2698831}, doi = {10.1002/hbm.20411}, issn = {1065-9471}, journal = {Human brain mapping}, keywords = {jc-hbm}, month = {April}, number = {4}, pages = {453--460}, posted-at = {2008-04-22 03:32:25}, priority = {2}, title = {Hemodynamic response to visual stimulation in newborn infants using functional near-infrared spectroscopy.}, url = {http://dx.doi.org/10.1002/hbm.20411}, volume = {29}, year = {2008} }

TY - JOUR ID - citeulike:2698831 L3 - citeulike-article-id:2698831 TI - Hemodynamic response to visual stimulation in newborn infants using functional near-infrared spectroscopy. JF - Human brain mapping VL - 29 IS - 4 SP - 453 EP - 460 AD - Clinic of Neonatology, University Hospital Zurich, Switzerland. SN - 1065-9471 N2 - Brain activity is associated with physiological changes, which alter the optical properties of tissue. These changes can be detected by near-infrared spectroscopy (NIRS). Aim of the study was to determine changes in cerebral oxygenation in response to stimulation in the visual cortex in newborn infants during spontaneous sleep in the first days of life. We used an in-house developed multichannel NIRS imaging instrument, the MCP-II, to measure changes in concentration of oxyhemoglobin (O(2)Hb) and deoxyhemoglobin (HHb) in specific brain areas. In 10 out of 15 subjects, a significant increase in O(2)Hb and/or a significant decrease in HHb were found in one or more channels over the occipital cortex. During stimulation, O(2)Hb increased by a mean of 0.98 mumol/l, HHb decreased by a mean 0.17 mumol/l, and total-Hb increased by a mean of 0.81 mumol/l. The hemodynamic response to visual stimulation in the occipital cortex in newborn infants is similar to adults. The increase in O(2)Hb and the simultaneous decrease in HHb during stimulation suggest an increase in cerebral blood flow (CBF) that overcompensates for the increased oxygen consumption (CMRO(2)) in the activated cortical area. Hum Brain Mapp, 2008. (c) 2007 Wiley-Liss, Inc. KW - jc-hbm AU - Karen, T AU - Morren, G AU - Haensse, D AU - Bauschatz, AS AU - Bucher, HU AU - Wolf, M PY - 2008/04// UR - http://dx.doi.org/10.1002/hbm.20411 ER -