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Energy estimation in protein design.

by: J Mendes, R Guerois, L Serrano
Curr Opin Struct Biol, Vol. 12, No. 4. (August 2002), pp. 441-446.


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The progress achieved by several groups in the field of computational protein design shows that successful design methods include two major features: efficient algorithms to deal with the combinatorial exploration of sequence space and optimal energy functions to rank sequences according to their fitness for the given fold.


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