Characterization of breast cancer by array comparative genomic hybridization.

@article{citeulike:2057661, abstract = {Cancer progression is due to the accumulation of recurrent genomic alterations that induce growth advantage and clonal expansion. Most of these genomic changes can be detected using the array comparative genomic hybridization (CGH) technique. The accurate classification of these genomic alterations is expected to have an important impact on translational and basic research. Here we review recent advances in CGH technology used in the characterization of different features of breast cancer. First, we present bioinformatics methods that have been developed for the analysis of CGH arrays; next, we discuss the use of array CGH technology to classify tumor stages and to identify and stratify subgroups of patients with different prognoses and clinical behaviors. We finish our review with a discussion of how CGH arrays are being used to identify oncogenes, tumor suppressor genes, and breast cancer susceptibility genes.}, address = {Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.}, author = {Climent, J. and Garcia, J. L. and Mao, J. H. and Arsuaga, J. and Perez-Losada, J. }, citeulike-article-id = {2057661}, doi = {http://dx.doi.org/10.1139/o07-072}, issn = {0829-8211}, journal = {Biochem Cell Biol}, keywords = {breast, cancer, cgh, characterization, mtdna, web-study}, month = {August}, number = {4}, pages = {497--508}, posted-at = {2008-07-16 22:17:49}, priority = {4}, title = {Characterization of breast cancer by array comparative genomic hybridization.}, url = {http://dx.doi.org/10.1139/o07-072}, volume = {85}, year = {2007} }

TY - JOUR ID - citeulike:2057661 L3 - citeulike-article-id:2057661 TI - Characterization of breast cancer by array comparative genomic hybridization. JF - Biochem Cell Biol VL - 85 IS - 4 SP - 497 EP - 508 AD - Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA. SN - 0829-8211 N2 - Cancer progression is due to the accumulation of recurrent genomic alterations that induce growth advantage and clonal expansion. Most of these genomic changes can be detected using the array comparative genomic hybridization (CGH) technique. The accurate classification of these genomic alterations is expected to have an important impact on translational and basic research. Here we review recent advances in CGH technology used in the characterization of different features of breast cancer. First, we present bioinformatics methods that have been developed for the analysis of CGH arrays; next, we discuss the use of array CGH technology to classify tumor stages and to identify and stratify subgroups of patients with different prognoses and clinical behaviors. We finish our review with a discussion of how CGH arrays are being used to identify oncogenes, tumor suppressor genes, and breast cancer susceptibility genes. KW - breast KW - cancer KW - cgh KW - characterization KW - mtdna KW - web-study AU - Climent, J AU - Garcia, JL AU - Mao, JH AU - Arsuaga, J AU - Perez-Losada, J PY - 2007/08// UR - http://dx.doi.org/10.1139/o07-072 ER -