The protein kinase complement of the human genome.

@article{citeulike:90452, abstract = {We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view of the current state of human genome analysis through a focus on one large gene family. We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases. New genes include members of well-studied families as well as previously unidentified families, some of which are conserved in model organisms. Classification and comparison with model organism kinomes identified orthologous groups and highlighted expansions specific to human and other lineages. We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons.}, address = {SUGEN Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA. gerard-manning@sugen.com}, author = {Manning, G. and Whyte, D. B. and Martinez, R. and Hunter, T. and Sudarsanam, S. }, citeulike-article-id = {90452}, doi = {http://dx.doi.org/10.1126/science.1075762}, issn = {1095-9203}, journal = {Science}, keywords = {datamining, functionnalgenomics, kinase}, month = {December}, number = {5600}, pages = {1912--1934}, posted-at = {2006-05-28 16:38:24}, priority = {0}, title = {The protein kinase complement of the human genome.}, url = {http://dx.doi.org/10.1126/science.1075762}, volume = {298}, year = {2002} }

TY - JOUR ID - citeulike:90452 L3 - citeulike-article-id:90452 TI - The protein kinase complement of the human genome. JF - Science VL - 298 IS - 5600 SP - 1912 EP - 1934 AD - SUGEN Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA. gerard-manning@sugen.com SN - 1095-9203 N2 - We have catalogued the protein kinase complement of the human genome (the "kinome") using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences. This provides a starting point for comprehensive analysis of protein phosphorylation in normal and disease states, as well as a detailed view of the current state of human genome analysis through a focus on one large gene family. We identify 518 putative protein kinase genes, of which 71 have not previously been reported or described as kinases, and we extend or correct the protein sequences of 56 more kinases. New genes include members of well-studied families as well as previously unidentified families, some of which are conserved in model organisms. Classification and comparison with model organism kinomes identified orthologous groups and highlighted expansions specific to human and other lineages. We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons. KW - datamining KW - functionnalgenomics KW - kinase AU - Manning, G AU - Whyte, DB AU - Martinez, R AU - Hunter, T AU - Sudarsanam, S PY - 2002/12/06/ UR - http://dx.doi.org/10.1126/science.1075762 ER -