CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast

by: Damian Brunner, Paul Nurse

Cell, Vol. 102, No. 5. (1 September 2000), pp. 695-704.

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Abstract

Rod-shaped fission yeast cells grow in a polarized manner, and unlike budding yeast, the correct positioning of the growth sites at cell ends requires interphase microtubules. Here we describe a microtubule guidance mechanism that orients microtubules in the intracellular space along the long axis of the cell, guiding them to their target region at the cell ends. This mechanism involves tip1p, a CLIP170-like protein that localizes to distal tips of cytoplasmic microtubules. In the absence of tip1p, microtubular catastrophe is no longer restricted to cell ends but occurs when microtubules reach any region of the cellular cortex. Thus, tip1p enables microtubules to discriminate different cortical regions and regulates their dynamics accordingly.

@article{Brunner2000, abstract = {Rod-shaped fission yeast cells grow in a polarized manner, and unlike budding yeast, the correct positioning of the growth sites at cell ends requires interphase microtubules. Here we describe a microtubule guidance mechanism that orients microtubules in the intracellular space along the long axis of the cell, guiding them to their target region at the cell ends. This mechanism involves tip1p, a CLIP170-like protein that localizes to distal tips of cytoplasmic microtubules. In the absence of tip1p, microtubular catastrophe is no longer restricted to cell ends but occurs when microtubules reach any region of the cellular cortex. Thus, tip1p enables microtubules to discriminate different cortical regions and regulates their dynamics accordingly.}, author = {Brunner, Damian and Nurse, Paul }, citeulike-article-id = {1365826}, doi = {http://dx.doi.org/10.1016/S0092-8674(00)00091-X}, journal = {Cell}, keywords = {maps, microtubules, pombe, yeast}, month = {September}, number = {5}, pages = {695--704}, posted-at = {2007-06-05 17:03:12}, priority = {3}, title = {CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast}, url = {http://dx.doi.org/10.1016/S0092-8674(00)00091-X}, volume = {102}, year = {2000} }

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TY - JOUR ID - Brunner2000 L3 - citeulike-article-id:1365826 TI - CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast JF - Cell VL - 102 IS - 5 SP - 695 EP - 704 N2 - Rod-shaped fission yeast cells grow in a polarized manner, and unlike budding yeast, the correct positioning of the growth sites at cell ends requires interphase microtubules. Here we describe a microtubule guidance mechanism that orients microtubules in the intracellular space along the long axis of the cell, guiding them to their target region at the cell ends. This mechanism involves tip1p, a CLIP170-like protein that localizes to distal tips of cytoplasmic microtubules. In the absence of tip1p, microtubular catastrophe is no longer restricted to cell ends but occurs when microtubules reach any region of the cellular cortex. Thus, tip1p enables microtubules to discriminate different cortical regions and regulates their dynamics accordingly. KW - maps KW - microtubules KW - pombe KW - yeast AU - Brunner, Damian AU - Nurse, Paul PY - 2000/09/01/ UR - http://dx.doi.org/10.1016/S0092-8674(00)00091-X ER -

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