Genome sequence of a serotype M28 strain of group a streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.

@article{citeulike:2461339, abstract = {Puerperal sepsis, a major cause of death of young women in Europe in the 1800s, was due predominantly to the gram-positive pathogen group A Streptococcus. Studies conducted during past decades have shown that serotype M28 strains are the major group A Streptococcus organisms responsible for many of these infections. To begin to increase our understanding of their enrichment in puerperal sepsis, we sequenced the genome of a genetically representative strain. This strain has genes encoding a novel array of prophage virulence factors, cell-surface proteins, and other molecules likely to contribute to host-pathogen interactions. Importantly, genes for 7 inferred extracellular proteins are encoded by a 37.4-kb foreign DNA element that is shared with group B Streptococcus and is present in all serotype M28 strains. Proteins encoded by the 37.4-kb element were expressed extracellularly and in human infections. Acquisition of foreign genes has helped create a disease-specialist clone of this pathogen.}, address = {Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA.}, author = {Green, N. M. and Zhang, S. and Porcella, S. F. and Nagiec, M. J. and Barbian, K. D. and Beres, S. B. and LeFebvre, R. B. and Musser, J. M. }, citeulike-article-id = {2461339}, doi = {10.1086/430618}, issn = {0022-1899}, journal = {J Infect Dis}, keywords = {genome}, month = {September}, number = {5}, pages = {760--770}, posted-at = {2008-03-03 18:03:32}, priority = {2}, title = {Genome sequence of a serotype M28 strain of group a streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.}, url = {http://dx.doi.org/10.1086/430618}, volume = {192}, year = {2005} }

TY - JOUR ID - citeulike:2461339 L3 - citeulike-article-id:2461339 TI - Genome sequence of a serotype M28 strain of group a streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity. JF - J Infect Dis VL - 192 IS - 5 SP - 760 EP - 770 AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, USA. SN - 0022-1899 N2 - Puerperal sepsis, a major cause of death of young women in Europe in the 1800s, was due predominantly to the gram-positive pathogen group A Streptococcus. Studies conducted during past decades have shown that serotype M28 strains are the major group A Streptococcus organisms responsible for many of these infections. To begin to increase our understanding of their enrichment in puerperal sepsis, we sequenced the genome of a genetically representative strain. This strain has genes encoding a novel array of prophage virulence factors, cell-surface proteins, and other molecules likely to contribute to host-pathogen interactions. Importantly, genes for 7 inferred extracellular proteins are encoded by a 37.4-kb foreign DNA element that is shared with group B Streptococcus and is present in all serotype M28 strains. Proteins encoded by the 37.4-kb element were expressed extracellularly and in human infections. Acquisition of foreign genes has helped create a disease-specialist clone of this pathogen. KW - genome AU - Green, NM AU - Zhang, S AU - Porcella, SF AU - Nagiec, MJ AU - Barbian, KD AU - Beres, SB AU - LeFebvre, RB AU - Musser, JM PY - 2005/09/01/ UR - http://dx.doi.org/10.1086/430618 ER -