Hyperthermic and lethal effects of methamphetamine: Roles of dopamine D1 and D2 receptors

@article{citeulike:2833138, abstract = {Both human and animal studies suggest that hyperthermia contributes to the lethal effects of methamphetamine. To elucidate the roles of dopamine D1 and D2 receptors in methamphetamine-induced hyperthermia and lethal effects, we used D1 knockout (D1KO) mice, D2 knockout (D2KO) mice, and wild-type littermates. After the administration (i.p.) of a single dose of 30 mg/kg methamphetamine, no hyperthermic effect on body temperature was observed in D2KO mice, though there was a slight elevation in D1KO mice and a marked elevation in wild-type mice. Approximately 27\% of the wild-type mice died after the administration, compared to only 7\% of D1KO mice and 4\% of D2KO mice. In conclusion, both D1 and D2 receptors play roles in the lethal toxic effects of methamphetamine, and mainly the D2 receptor is involved in the elevation of body temperature.}, author = {Ito, Miki and Numachi, Yohtaro and Ohara, Arihisa and Sora, Ichiro }, citeulike-article-id = {2833138}, doi = {http://dx.doi.org/10.1016/j.neulet.2008.04.034}, journal = {Neuroscience Letters}, keywords = {amphetamine, dopamine, mouse}, posted-at = {2008-05-26 09:44:35}, priority = {2}, title = {Hyperthermic and lethal effects of methamphetamine: Roles of dopamine D1 and D2 receptors}, url = {http://dx.doi.org/10.1016/j.neulet.2008.04.034}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:2833138 L3 - citeulike-article-id:2833138 TI - Hyperthermic and lethal effects of methamphetamine: Roles of dopamine D1 and D2 receptors JF - Neuroscience Letters VL - In Press, Corrected Proof N2 - Both human and animal studies suggest that hyperthermia contributes to the lethal effects of methamphetamine. To elucidate the roles of dopamine D1 and D2 receptors in methamphetamine-induced hyperthermia and lethal effects, we used D1 knockout (D1KO) mice, D2 knockout (D2KO) mice, and wild-type littermates. After the administration (i.p.) of a single dose of 30 mg/kg methamphetamine, no hyperthermic effect on body temperature was observed in D2KO mice, though there was a slight elevation in D1KO mice and a marked elevation in wild-type mice. Approximately 27% of the wild-type mice died after the administration, compared to only 7% of D1KO mice and 4% of D2KO mice. In conclusion, both D1 and D2 receptors play roles in the lethal toxic effects of methamphetamine, and mainly the D2 receptor is involved in the elevation of body temperature. KW - amphetamine KW - dopamine KW - mouse AU - Ito, Miki AU - Numachi, Yohtaro AU - Ohara, Arihisa AU - Sora, Ichiro UR - http://dx.doi.org/10.1016/j.neulet.2008.04.034 ER -