A bacterial metapopulation adapts locally to phage predation despite global dispersal

by: Victor Kunin, Shaomei He, Falk Warnecke, Brook S Peterson, Garcia, Matthew Haynes, Natalia Ivanova, Linda L Blackall, Mya Breitbart, Forest Rohwer, Katherine D Mcmahon, Philip Hugenholtz

Genome Res., Vol. 18, No. 2. (1 February 2008), pp. 293-297.

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Abstract

Using a combination of bacterial and phage-targeted metagenomics, we analyzed two geographically remote sludge bioreactors enriched in a single bacterial species Candidatus Accumulibacter phosphatis (CAP). We inferred unrestricted global movement of this species and identified aquatic ecosystems as the primary environmental reservoirs facilitating dispersal. Highly related and geographically remote CAP strains differed principally in genomic regions encoding phage defense mechanisms. We found that CAP populations were high density, clonal, and nonrecombining, providing natural targets for "kill-the-winner" phage predation. Community expression analysis demonstrated that phages were consistently active in the bioreactor community. Genomic signatures linking CAP to past phage exposures were observed mostly between local phage and host. We conclude that CAP strains disperse globally but must adapt to phage predation pressure locally. 10.1101/gr.6835308

@article{citeulike:2659249, abstract = {Using a combination of bacterial and phage-targeted metagenomics, we analyzed two geographically remote sludge bioreactors enriched in a single bacterial species Candidatus Accumulibacter phosphatis (CAP). We inferred unrestricted global movement of this species and identified aquatic ecosystems as the primary environmental reservoirs facilitating dispersal. Highly related and geographically remote CAP strains differed principally in genomic regions encoding phage defense mechanisms. We found that CAP populations were high density, clonal, and nonrecombining, providing natural targets for "kill-the-winner" phage predation. Community expression analysis demonstrated that phages were consistently active in the bioreactor community. Genomic signatures linking CAP to past phage exposures were observed mostly between local phage and host. We conclude that CAP strains disperse globally but must adapt to phage predation pressure locally. 10.1101/gr.6835308}, author = {Kunin, Victor and He, Shaomei and Warnecke, Falk and Peterson, Brook S. and Garcia and Haynes, Matthew and Ivanova, Natalia and Blackall, Linda L. and Breitbart, Mya and Rohwer, Forest and Mcmahon, Katherine D. and Hugenholtz, Philip }, citeulike-article-id = {2659249}, doi = {http://dx.doi.org/10.1101/gr.6835308}, journal = {Genome Res.}, keywords = {adaptation, biogeography, community, ecology, microbial}, month = {February}, number = {2}, pages = {293--297}, posted-at = {2008-04-14 08:35:17}, priority = {3}, title = {A bacterial metapopulation adapts locally to phage predation despite global dispersal}, url = {http://dx.doi.org/10.1101/gr.6835308}, volume = {18}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2659249 L3 - citeulike-article-id:2659249 TI - A bacterial metapopulation adapts locally to phage predation despite global dispersal JF - Genome Res. VL - 18 IS - 2 SP - 293 EP - 297 N2 - Using a combination of bacterial and phage-targeted metagenomics, we analyzed two geographically remote sludge bioreactors enriched in a single bacterial species Candidatus Accumulibacter phosphatis (CAP). We inferred unrestricted global movement of this species and identified aquatic ecosystems as the primary environmental reservoirs facilitating dispersal. Highly related and geographically remote CAP strains differed principally in genomic regions encoding phage defense mechanisms. We found that CAP populations were high density, clonal, and nonrecombining, providing natural targets for "kill-the-winner" phage predation. Community expression analysis demonstrated that phages were consistently active in the bioreactor community. Genomic signatures linking CAP to past phage exposures were observed mostly between local phage and host. We conclude that CAP strains disperse globally but must adapt to phage predation pressure locally. 10.1101/gr.6835308 KW - adaptation KW - biogeography KW - community KW - ecology KW - microbial AU - Kunin, Victor AU - He, Shaomei AU - Warnecke, Falk AU - Peterson, Brook AU - Garcia AU - Haynes, Matthew AU - Ivanova, Natalia AU - Blackall, Linda AU - Breitbart, Mya AU - Rohwer, Forest AU - Mcmahon, Katherine AU - Hugenholtz, Philip PY - 2008/02/01/ UR - http://dx.doi.org/10.1101/gr.6835308 ER -

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