Oncogene-induced senescence pathways weave an intricate tapestry.

@article{citeulike:1159113, abstract = {The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.}, address = {Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720, USA. p\_yaswen@lbl.gov}, author = {Yaswen, P. and Campisi, J. }, citeulike-article-id = {1159113}, doi = {10.1016/j.cell.2007.01.005}, issn = {0092-8674}, journal = {Cell}, keywords = {biology, cancer}, month = {January}, number = {2}, pages = {233--234}, posted-at = {2007-03-14 07:11:25}, priority = {2}, title = {Oncogene-induced senescence pathways weave an intricate tapestry.}, url = {http://dx.doi.org/10.1016/j.cell.2007.01.005}, volume = {128}, year = {2007} }

TY - JOUR ID - citeulike:1159113 L3 - citeulike-article-id:1159113 TI - Oncogene-induced senescence pathways weave an intricate tapestry. JF - Cell VL - 128 IS - 2 SP - 233 EP - 234 AD - Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720, USA. p_yaswen@lbl.gov SN - 0092-8674 N2 - The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53. KW - biology KW - cancer AU - Yaswen, P AU - Campisi, J PY - 2007/01/26/ UR - http://dx.doi.org/10.1016/j.cell.2007.01.005 ER -