Peripheral Circulatory Effects of Insulin in Diabetes

@article{citeulike:2754310, abstract = {Peripheral circulatory effects of insulin were studied in the diabetic patients with and without autonomic neuropathy. Forearm blood flow, calf venous vol ume and calf venous distensibility were measured by strain gauge plethysmo graphy. In the diabetic patients with autonomic neuropathy, mean blood pres sure fell from 96{+/-}5 to 88{+/-}5 mmHg after an intravenous injection of 4 U of monocomponent insulin (p < 0.001). Forearm vascular resistance decreased from 53.99{+/-}8.29 to 45.88{+/-}7.76 mmHg*ml -1*100ml-1*min-1 after insulin (p < 0.01). Insulin increased calf venous volume from 1.20{+/-}0.19 to 2.23{+/-}0.44 ml/100ml (p < 0.05) and calf venous distensibility from 0.039{+/-}0.004 to 0.082{+/-}0.016 ml/mmHg (p < 0.05). In contrast, in the diabetic patients without autonomic neuropathy, there were no significant changes in the mean blood pressure, forearm vascular resistance, calf venous volume and calf venous dis tensibility. Symptoms of hypoglycaemia did not occur in any patient. These results suggest that insulin has a vasodilator action on both resistance and capacitance vessels, which may be one of the main factors in insulin-in duced hypotension. 10.1177/000331978503600207}, author = {Takata, Shigeo and Yamamoto, Masakazu and Yagi, Shinji and Noto, Yutaka and Ikeda, Takayuki and Hattori, Nobu }, citeulike-article-id = {2754310}, journal = {Angiology}, keywords = {blood\_pressure, dan, diabetes, insulin\_secretion, neuropathy}, month = {February}, number = {2}, pages = {110--115}, posted-at = {2008-05-04 18:57:04}, priority = {2}, title = {Peripheral Circulatory Effects of Insulin in Diabetes}, url = {http://ang.sagepub.com/cgi/content/abstract/36/2/110}, volume = {36}, year = {1985} }

TY - JOUR ID - citeulike:2754310 L3 - citeulike-article-id:2754310 TI - Peripheral Circulatory Effects of Insulin in Diabetes JF - Angiology VL - 36 IS - 2 SP - 110 EP - 115 N2 - Peripheral circulatory effects of insulin were studied in the diabetic patients with and without autonomic neuropathy. Forearm blood flow, calf venous vol ume and calf venous distensibility were measured by strain gauge plethysmo graphy. In the diabetic patients with autonomic neuropathy, mean blood pres sure fell from 96{+/-}5 to 88{+/-}5 mmHg after an intravenous injection of 4 U of monocomponent insulin (p < 0.001). Forearm vascular resistance decreased from 53.99{+/-}8.29 to 45.88{+/-}7.76 mmHg*ml -1*100ml-1*min-1 after insulin (p < 0.01). Insulin increased calf venous volume from 1.20{+/-}0.19 to 2.23{+/-}0.44 ml/100ml (p < 0.05) and calf venous distensibility from 0.039{+/-}0.004 to 0.082{+/-}0.016 ml/mmHg (p < 0.05). In contrast, in the diabetic patients without autonomic neuropathy, there were no significant changes in the mean blood pressure, forearm vascular resistance, calf venous volume and calf venous dis tensibility. Symptoms of hypoglycaemia did not occur in any patient. These results suggest that insulin has a vasodilator action on both resistance and capacitance vessels, which may be one of the main factors in insulin-in duced hypotension. 10.1177/000331978503600207 KW - blood_pressure KW - dan KW - diabetes KW - insulin_secretion KW - neuropathy AU - Takata, Shigeo AU - Yamamoto, Masakazu AU - Yagi, Shinji AU - Noto, Yutaka AU - Ikeda, Takayuki AU - Hattori, Nobu PY - 1985/02/01/ UR - http://ang.sagepub.com/cgi/content/abstract/36/2/110 ER -