Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney.

@article{citeulike:812475, abstract = {We investigated the relationship between body size, Na(+)-K(+)-ATPase molecular activity, and membrane lipid composition in the kidney of five mammalian and eight avian species ranging from 30-g mice to 280-kg cattle and 13-g zebra finches to 35-kg emus, respectively. Na(+)-K(+)-ATPase activity was found to be higher in the smaller species of both groups. In small mammals, the higher Na(+)-K(+)-ATPase activity was primarily the result of an increase in the molecular activity (turnover rate) of individual enzymes, whereas in small birds the higher Na(+)-K(+)-ATPase activity was the result of an increased enzyme concentration. Phospholipids from both mammals and birds contained a relatively constant percentage of unsaturated fatty acids; however, phospholipids from the smaller species were generally more polyunsaturated, and a complementary significant allometric increase in monounsaturate content was observed in the larger species. In particular, the relative content of the highly polyunsaturated docosahexaenoic acid [22:6(n-3)] displayed the greatest variation with body mass, scaling with allometric exponents of -0.21 and -0.26 in the mammals and birds, respectively. This allometric variation in fatty acid composition was correlated with Na(+)-K(+)-ATPase molecular activity in mammals, whereas in birds molecular activity only correlated with membrane cholesterol content. These relationships are discussed with respect to the metabolic intensity of different-sized animals.}, address = {Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia. nigelt@uow.edu.au}, author = {Turner, N. and Haga, K. L. and Hulbert, A. J. and Else, P. L. }, citeulike-article-id = {812475}, doi = {10.1152/ajpregu.00297.2004}, issn = {0363-6119}, journal = {Am J Physiol Regul Integr Comp Physiol}, keywords = {composition, lipid, membrane}, month = {January}, number = {1}, posted-at = {2006-08-22 10:48:29}, priority = {2}, title = {Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney.}, url = {http://dx.doi.org/10.1152/ajpregu.00297.2004}, volume = {288}, year = {2005} }

TY - JOUR ID - citeulike:812475 L3 - citeulike-article-id:812475 TI - Relationship between body size, Na+-K+-ATPase activity, and membrane lipid composition in mammal and bird kidney. JF - Am J Physiol Regul Integr Comp Physiol VL - 288 IS - 1 AD - Metabolic Research Centre, Department of Biomedical Science, University of Wollongong, Wollongong, New South Wales 2522, Australia. nigelt@uow.edu.au SN - 0363-6119 N2 - We investigated the relationship between body size, Na(+)-K(+)-ATPase molecular activity, and membrane lipid composition in the kidney of five mammalian and eight avian species ranging from 30-g mice to 280-kg cattle and 13-g zebra finches to 35-kg emus, respectively. Na(+)-K(+)-ATPase activity was found to be higher in the smaller species of both groups. In small mammals, the higher Na(+)-K(+)-ATPase activity was primarily the result of an increase in the molecular activity (turnover rate) of individual enzymes, whereas in small birds the higher Na(+)-K(+)-ATPase activity was the result of an increased enzyme concentration. Phospholipids from both mammals and birds contained a relatively constant percentage of unsaturated fatty acids; however, phospholipids from the smaller species were generally more polyunsaturated, and a complementary significant allometric increase in monounsaturate content was observed in the larger species. In particular, the relative content of the highly polyunsaturated docosahexaenoic acid [22:6(n-3)] displayed the greatest variation with body mass, scaling with allometric exponents of -0.21 and -0.26 in the mammals and birds, respectively. This allometric variation in fatty acid composition was correlated with Na(+)-K(+)-ATPase molecular activity in mammals, whereas in birds molecular activity only correlated with membrane cholesterol content. These relationships are discussed with respect to the metabolic intensity of different-sized animals. KW - composition KW - lipid KW - membrane AU - Turner, N AU - Haga, KL AU - Hulbert, AJ AU - Else, PL PY - 2005/01// UR - http://dx.doi.org/10.1152/ajpregu.00297.2004 ER -