The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways.

@article{citeulike:2415338, abstract = {Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel alpha subunit in nociception and pain by constructing sns-null mutant mice. These mice expressed only TTX-sensitive sodium currents on step depolarizations from normal resting potentials, showing that all slow TTX-resistant currents are encoded by the sns gene. Null mutants were viable, fertile and apparently normal, although lowered thresholds of electrical activation of C-fibers and increased current densities of TTX-sensitive channels demonstrated compensatory upregulation of TTX-sensitive currents in sensory neurons. Behavioral studies demonstrated a pronounced analgesia to noxious mechanical stimuli, small deficits in noxious thermoreception and delayed development of inflammatory hyperalgesia. These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects.}, address = {Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK.}, author = {Akopian, A. N. and Souslova, V. and England, S. and Okuse, K. and Ogata, N. and Ure, J. and Smith, A. and Kerr, B. J. and McMahon, S. B. and Boyce, S. and Hill, R. and Stanfa, L. C. and Dickenson, A. H. and Wood, J. N. }, citeulike-article-id = {2415338}, doi = {10.1038/9195}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {nociceptor, ttx-resistant}, month = {June}, number = {6}, pages = {541--548}, posted-at = {2008-05-13 21:04:19}, priority = {0}, title = {The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways.}, url = {http://dx.doi.org/10.1038/9195}, volume = {2}, year = {1999} }

TY - JOUR ID - citeulike:2415338 L3 - citeulike-article-id:2415338 TI - The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. JF - Nat Neurosci VL - 2 IS - 6 SP - 541 EP - 548 AD - Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK. SN - 1097-6256 N2 - Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant sodium channel alpha subunit in nociception and pain by constructing sns-null mutant mice. These mice expressed only TTX-sensitive sodium currents on step depolarizations from normal resting potentials, showing that all slow TTX-resistant currents are encoded by the sns gene. Null mutants were viable, fertile and apparently normal, although lowered thresholds of electrical activation of C-fibers and increased current densities of TTX-sensitive channels demonstrated compensatory upregulation of TTX-sensitive currents in sensory neurons. Behavioral studies demonstrated a pronounced analgesia to noxious mechanical stimuli, small deficits in noxious thermoreception and delayed development of inflammatory hyperalgesia. These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects. KW - nociceptor KW - ttx-resistant AU - Akopian, AN AU - Souslova, V AU - England, S AU - Okuse, K AU - Ogata, N AU - Ure, J AU - Smith, A AU - Kerr, BJ AU - McMahon, SB AU - Boyce, S AU - Hill, R AU - Stanfa, LC AU - Dickenson, AH AU - Wood, JN PY - 1999/06// UR - http://dx.doi.org/10.1038/9195 ER -