Mechanisms of obesity-associated insulin resistance: many choices on the menu

by: Mohammed Qatanani, Mitchell A Lazar

Genes Dev., Vol. 21, No. 12. (15 June 2007), pp. 1443-1455.

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Abstract

Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. In the past decade, a large number of endocrine, inflammatory, neural, and cell-intrinsic pathways have been shown to be dysregulated in obesity. Although it is possible that one of these factors plays a dominant role, many of these factors are interdependent, and it is likely that their dynamic interplay underlies the pathophysiology of insulin resistance. Understanding the biology of these systems will inform the search for interventions that specifically prevent or treat insulin resistance and its associated pathologies. 10.1101/gad.1550907

@article{citeulike:2714505, abstract = {Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. In the past decade, a large number of endocrine, inflammatory, neural, and cell-intrinsic pathways have been shown to be dysregulated in obesity. Although it is possible that one of these factors plays a dominant role, many of these factors are interdependent, and it is likely that their dynamic interplay underlies the pathophysiology of insulin resistance. Understanding the biology of these systems will inform the search for interventions that specifically prevent or treat insulin resistance and its associated pathologies. 10.1101/gad.1550907}, author = {Qatanani, Mohammed and Lazar, Mitchell A. }, citeulike-article-id = {2714505}, doi = {http://dx.doi.org/10.1101/gad.1550907}, journal = {Genes Dev.}, keywords = {insulin-resistance, obesity}, month = {June}, number = {12}, pages = {1443--1455}, posted-at = {2008-04-24 23:25:59}, priority = {2}, title = {Mechanisms of obesity-associated insulin resistance: many choices on the menu}, url = {http://dx.doi.org/10.1101/gad.1550907}, volume = {21}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2714505 L3 - citeulike-article-id:2714505 TI - Mechanisms of obesity-associated insulin resistance: many choices on the menu JF - Genes Dev. VL - 21 IS - 12 SP - 1443 EP - 1455 N2 - Obesity-associated insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. In the past decade, a large number of endocrine, inflammatory, neural, and cell-intrinsic pathways have been shown to be dysregulated in obesity. Although it is possible that one of these factors plays a dominant role, many of these factors are interdependent, and it is likely that their dynamic interplay underlies the pathophysiology of insulin resistance. Understanding the biology of these systems will inform the search for interventions that specifically prevent or treat insulin resistance and its associated pathologies. 10.1101/gad.1550907 KW - insulin-resistance KW - obesity AU - Qatanani, Mohammed AU - Lazar, Mitchell PY - 2007/06/15/ UR - http://dx.doi.org/10.1101/gad.1550907 ER -

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