Cerebellar complex spike firing is suitable to induce as well as to stabilize motor learning.

@article{citeulike:998685, abstract = {BACKGROUND: Cerebellar Purkinje cells (PC) generate two responses: the simple spike (SS), with high firing rates (>100 Hz), and the complex spike (CS), characterized by conspicuously low discharge rates (1-2 Hz). Contemporary theories of cerebellar learning suggest that the CS discharge pattern encodes an error signal that drives changes in SS activity, ultimately related to motor behavior. This then predicts that CS will discharge in relation to the error and at random once the error has been nulled by the new behavior. RESULTS: We tested this hypothesis with saccadic adaptation in macaque monkeys as a model of cerebellar-dependent motor learning. During saccadic adaptation, error information unconsciously changes the endpoint of a saccade prompted by a visual target that shifts its final position during the saccade. We recorded CS from PC of the posterior vermis before, during, and after saccadic adaptation. In clear contradiction to the "error signal" concept, we found that CS occurred at random before adaptation onset, i.e., when the error was maximal, and built up to a specific saccade-related discharge profile during the course of adaptation. This profile became most pronounced at the end of adaptation, i.e., when the error had been nulled. CONCLUSIONS: We suggest that CS firing may underlie the stabilization of a learned motor behavior, rather than serving as an electrophysiological correlate of an error.}, address = {Department of Cognitive Neurology, Center of Neurology, University of T\"{u}bingen, Hertie Institute for Clinical Brain Research, Ottfried M\"{u}ller Strasse 27, 72076 T\"{u}bingen, Germany.}, author = {Catz, N. and Dicke, P. W. and Thier, P. }, citeulike-article-id = {998685}, doi = {10.1016/j.cub.2005.11.037}, issn = {0960-9822}, journal = {Curr Biol}, keywords = {cerebellum, learning, motor}, month = {December}, number = {24}, pages = {2179--2189}, posted-at = {2008-04-09 14:50:25}, priority = {5}, title = {Cerebellar complex spike firing is suitable to induce as well as to stabilize motor learning.}, url = {http://dx.doi.org/10.1016/j.cub.2005.11.037}, volume = {15}, year = {2005} }

TY - JOUR ID - citeulike:998685 L3 - citeulike-article-id:998685 TI - Cerebellar complex spike firing is suitable to induce as well as to stabilize motor learning. JF - Curr Biol VL - 15 IS - 24 SP - 2179 EP - 2189 AD - Department of Cognitive Neurology, Center of Neurology, University of Tübingen, Hertie Institute for Clinical Brain Research, Ottfried Müller Strasse 27, 72076 Tübingen, Germany. SN - 0960-9822 N2 - BACKGROUND: Cerebellar Purkinje cells (PC) generate two responses: the simple spike (SS), with high firing rates (>100 Hz), and the complex spike (CS), characterized by conspicuously low discharge rates (1-2 Hz). Contemporary theories of cerebellar learning suggest that the CS discharge pattern encodes an error signal that drives changes in SS activity, ultimately related to motor behavior. This then predicts that CS will discharge in relation to the error and at random once the error has been nulled by the new behavior. RESULTS: We tested this hypothesis with saccadic adaptation in macaque monkeys as a model of cerebellar-dependent motor learning. During saccadic adaptation, error information unconsciously changes the endpoint of a saccade prompted by a visual target that shifts its final position during the saccade. We recorded CS from PC of the posterior vermis before, during, and after saccadic adaptation. In clear contradiction to the "error signal" concept, we found that CS occurred at random before adaptation onset, i.e., when the error was maximal, and built up to a specific saccade-related discharge profile during the course of adaptation. This profile became most pronounced at the end of adaptation, i.e., when the error had been nulled. CONCLUSIONS: We suggest that CS firing may underlie the stabilization of a learned motor behavior, rather than serving as an electrophysiological correlate of an error. KW - cerebellum KW - learning KW - motor AU - Catz, N AU - Dicke, PW AU - Thier, P PY - 2005/12/20/ UR - http://dx.doi.org/10.1016/j.cub.2005.11.037 ER -