The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs.

@article{citeulike:3200006, abstract = {Objective To investigate the influence of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and reduction in pulse rate (PR) in dogs. Study design Randomized, cross-over. Animals Six healthy laboratory Beagles. Methods All animals received dexmedetomidine (5 mug kg(-1) IV, DEX) alone or in combination with L-659,066 (250 mug kg(-1) IV, DEX + L) with a 7-day rest period between treatments. Sedation was assessed using a composite sedation score and PRs were recorded. Atipamezole (50 mug kg(-1) IM, ATI) was administered to reverse the sedation. Overnight Holter-monitoring was carried out to obtain a minimum heart rate (MHR) at rest. Results Bioequivalence was shown for clinical sedation between DEX and DEX + L. Heart rate was significantly higher with DEX + L during the period of sedation. Bioequivalence was demonstrated between MHR and PR in the DEX + L group during the period of sedation. Recoveries after ATI were uneventful. Conclusions L-659,066 did not affect the quality of dexmedetomidine-induced sedation whilst it attenuated the reduction in PR. Thus, L-659,066 could prove a useful adjunct to reduce the peripheral cardiovascular effects attributed to dexmedetomidine in dogs. Clinical relevance The clinical safety of alpha2-adrenoceptor agonists could be markedly improved with less peripheral cardiovascular effects.}, address = {Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.}, author = {Honkavaara, Juhana M M. and Raekallio, Marja R R. and Kuusela, Erja K K. and Hyv\"{a}rinen, Esko A A. and Vainio, Outi M M. }, citeulike-article-id = {3200006}, doi = {http://dx.doi.org/10.1111/j.1467-2995.2008.00403.x}, issn = {1467-2995}, journal = {Veterinary anaesthesia and analgesia}, keywords = {alpha-2-adrenoceptor, antagonist, dog, peripheral, september-08}, month = {May}, posted-at = {2008-09-06 21:42:33}, priority = {3}, title = {The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs.}, url = {http://dx.doi.org/10.1111/j.1467-2995.2008.00403.x}, year = {2008} }

TY - JOUR ID - citeulike:3200006 L3 - citeulike-article-id:3200006 N2 - Objective To investigate the influence of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and reduction in pulse rate (PR) in dogs. Study design Randomized, cross-over. Animals Six healthy laboratory Beagles. Methods All animals received dexmedetomidine (5 mug kg(-1) IV, DEX) alone or in combination with L-659,066 (250 mug kg(-1) IV, DEX + L) with a 7-day rest period between treatments. Sedation was assessed using a composite sedation score and PRs were recorded. Atipamezole (50 mug kg(-1) IM, ATI) was administered to reverse the sedation. Overnight Holter-monitoring was carried out to obtain a minimum heart rate (MHR) at rest. Results Bioequivalence was shown for clinical sedation between DEX and DEX + L. Heart rate was significantly higher with DEX + L during the period of sedation. Bioequivalence was demonstrated between MHR and PR in the DEX + L group during the period of sedation. Recoveries after ATI were uneventful. Conclusions L-659,066 did not affect the quality of dexmedetomidine-induced sedation whilst it attenuated the reduction in PR. Thus, L-659,066 could prove a useful adjunct to reduce the peripheral cardiovascular effects attributed to dexmedetomidine in dogs. Clinical relevance The clinical safety of alpha2-adrenoceptor agonists could be markedly improved with less peripheral cardiovascular effects. JF - Veterinary anaesthesia and analgesia SN - 1467-2995 AD - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland. TI - The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs. KW - alpha-2-adrenoceptor KW - antagonist KW - dog KW - peripheral KW - september-08 AU - Honkavaara, Juhana M AU - Raekallio, Marja R AU - Kuusela, Erja K AU - Hyvärinen, Esko A AU - Vainio, Outi M PY - 2008/05/05/ UR - http://dx.doi.org/10.1111/j.1467-2995.2008.00403.x ER -