Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs.

@article{citeulike:2964965, abstract = {To test the hypothesis that acepromazine could potentiate the sedative actions and attenuate the pressor response induced by dexmedetomidine, the effects of acepromazine or atropine were compared in six healthy adult dogs treated with this alpha(2)-agonist. In a randomised block design, the dogs received intravenous doses of either physiological saline, 0.05 mg/kg acepromazine or 0.04 mg/kg atropine, 15 minutes before an intravenous dose of 5 mug/kg dexmedetomidine. The dogs' heart rate was reduced by 50 to 63 per cent from baseline and their mean arterial blood pressure was increased transiently from baseline for 20 minutes after the dexmedetomidine. Atropine prevented the alpha(2)-agonist-induced bradycardia and increased the severity and duration of the hypertension, but acepromazine did not substantially modify the cardiovascular effects of the alpha(2)-agonist, except for a slight reduction in the magnitude and duration of its pressor effects. The dexmedetomidine induced moderate to intense sedation in all the treatments, but the dogs' sedation scores did not differ among treatments. The combination of acepromazine with dexmedetomidine had no obvious advantages in comparison with dexmedetomidine alone, but the administration of atropine before dexmedetomidine is contraindicated because of a severe hypertensive response.}, address = {Departamento de Cirurgia e Anestesiologia Veterin\'{a}ria, Faculdade de Medicina Veterin\'{a}ria e Zootecnia, Universidade Estadual Paulista, Botucatu, S\~{a}o Paulo, cep 18618-000, Brazil.}, author = {Alvaides, R. K. and Neto, F. J. and Aguiar, A. J. and Campagnol, D. and Steagall, P. V. }, citeulike-article-id = {2964965}, issn = {0042-4900}, journal = {The Veterinary record}, keywords = {acp, atropine, dexmedetomidine, dogs, june-08}, month = {June}, number = {26}, pages = {852--856}, posted-at = {2008-07-04 20:34:31}, priority = {2}, title = {Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18587062}, volume = {162}, year = {2008} }

TY - JOUR ID - citeulike:2964965 L3 - citeulike-article-id:2964965 N2 - To test the hypothesis that acepromazine could potentiate the sedative actions and attenuate the pressor response induced by dexmedetomidine, the effects of acepromazine or atropine were compared in six healthy adult dogs treated with this alpha(2)-agonist. In a randomised block design, the dogs received intravenous doses of either physiological saline, 0.05 mg/kg acepromazine or 0.04 mg/kg atropine, 15 minutes before an intravenous dose of 5 mug/kg dexmedetomidine. The dogs' heart rate was reduced by 50 to 63 per cent from baseline and their mean arterial blood pressure was increased transiently from baseline for 20 minutes after the dexmedetomidine. Atropine prevented the alpha(2)-agonist-induced bradycardia and increased the severity and duration of the hypertension, but acepromazine did not substantially modify the cardiovascular effects of the alpha(2)-agonist, except for a slight reduction in the magnitude and duration of its pressor effects. The dexmedetomidine induced moderate to intense sedation in all the treatments, but the dogs' sedation scores did not differ among treatments. The combination of acepromazine with dexmedetomidine had no obvious advantages in comparison with dexmedetomidine alone, but the administration of atropine before dexmedetomidine is contraindicated because of a severe hypertensive response. IS - 26 JF - The Veterinary record SN - 0042-4900 AD - Departamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, São Paulo, cep 18618-000, Brazil. EP - 856 TI - Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs. VL - 162 SP - 852 KW - acp KW - atropine KW - dexmedetomidine KW - dogs KW - june-08 AU - Alvaides, RK AU - Neto, FJ AU - Aguiar, AJ AU - Campagnol, D AU - Steagall, PV PY - 2008/06/28/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18587062 ER -