The 5-HT(7) receptor influences stereotypic behavior in a model of obsessive-compulsive disorder.

@article{citeulike:1222150, abstract = {The 5-HT(7) receptor has been suggested as a new putative target for the treatment of neuropsychiatric disorders, especially depression. This hypothesis is based on the finding that antidepressant drugs have relatively high affinity for the 5-HT(7) receptor, and that inactivation or blockade of the receptor leads to an antidepressant-like profile in behavioral models and sleep parameters. Obsessive-compulsive disorder is also believed to involve the serotonergic system and is treated using antidepressants, thus it is of interest to study the possible role of the 5-HT(7) receptor in this disorder. We have evaluated the effect of inactivation or pharmacological blockade of the 5-HT(7) receptor in three mouse behavioral models that are believed to mimic some of the stereotypic aspects of obsessive-compulsive disorder. In the most well-established behavioral model, marble burying, both inactivation and blockade of the 5-HT(7) receptor reduced stereotypic behavior in that the number of marbles buried decreased. In two newer, less well-characterized models, head dipping and plastic-mesh screen chewing, there was no difference between wild-type mice and mice lacking the 5-HT(7) receptor. Taken together the data confirms and expands on previous findings that the 5-HT(7) receptor is of importance for behaviors affected by antidepressants, and suggests that the 5-HT(7) receptor might be of relevance as a target for the treatment of obsessive-compulsive disorder.}, address = {Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.}, author = {Hedlund, P. B. and Sutcliffe, J. G. }, citeulike-article-id = {1222150}, doi = {10.1016/j.neulet.2006.12.054}, issn = {0304-3940}, journal = {Neurosci Lett}, keywords = {5-ht7}, month = {March}, number = {3}, pages = {247--251}, posted-at = {2007-04-12 13:20:24}, priority = {2}, title = {The 5-HT(7) receptor influences stereotypic behavior in a model of obsessive-compulsive disorder.}, url = {http://dx.doi.org/10.1016/j.neulet.2006.12.054}, volume = {414}, year = {2007} }

TY - JOUR ID - citeulike:1222150 L3 - citeulike-article-id:1222150 TI - The 5-HT(7) receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. JF - Neurosci Lett VL - 414 IS - 3 SP - 247 EP - 251 AD - Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. SN - 0304-3940 N2 - The 5-HT(7) receptor has been suggested as a new putative target for the treatment of neuropsychiatric disorders, especially depression. This hypothesis is based on the finding that antidepressant drugs have relatively high affinity for the 5-HT(7) receptor, and that inactivation or blockade of the receptor leads to an antidepressant-like profile in behavioral models and sleep parameters. Obsessive-compulsive disorder is also believed to involve the serotonergic system and is treated using antidepressants, thus it is of interest to study the possible role of the 5-HT(7) receptor in this disorder. We have evaluated the effect of inactivation or pharmacological blockade of the 5-HT(7) receptor in three mouse behavioral models that are believed to mimic some of the stereotypic aspects of obsessive-compulsive disorder. In the most well-established behavioral model, marble burying, both inactivation and blockade of the 5-HT(7) receptor reduced stereotypic behavior in that the number of marbles buried decreased. In two newer, less well-characterized models, head dipping and plastic-mesh screen chewing, there was no difference between wild-type mice and mice lacking the 5-HT(7) receptor. Taken together the data confirms and expands on previous findings that the 5-HT(7) receptor is of importance for behaviors affected by antidepressants, and suggests that the 5-HT(7) receptor might be of relevance as a target for the treatment of obsessive-compulsive disorder. KW - 5-ht7 AU - Hedlund, PB AU - Sutcliffe, JG PY - 2007/03/13/ UR - http://dx.doi.org/10.1016/j.neulet.2006.12.054 ER -