Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation.

@article{citeulike:2959038, abstract = {Organisms are constantly exposed to a wide range of environmental changes, including both short-term changes during their lifetime and longer-term changes across generations. Stress-related gene expression programmes, characterized by distinct transcriptional mechanisms and high levels of noise in their expression patterns, need to be balanced with growth-related gene expression programmes. A range of recent studies give fascinating insight into cellular strategies for keeping gene expression in tune with physiological needs dictated by the environment, promoting adaptation to both short- and long-term environmental changes. Not only do organisms show great resilience to external challenges, but emerging data suggest that they also exploit these challenges to fuel phenotypic variation and evolutionary innovation.}, address = {Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, London WC1E 6BT, UK.}, author = {L\'{o}pez-Maury, Luis and Marguerat, Samuel and B\"{a}hler, J\"{u}rg }, citeulike-article-id = {2959038}, doi = {http://dx.doi.org/10.1038/nrg2398}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, month = {July}, posted-at = {2008-07-18 14:19:24}, priority = {2}, title = {Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation.}, url = {http://dx.doi.org/10.1038/nrg2398}, year = {2008} }

TY - JOUR ID - citeulike:2959038 L3 - citeulike-article-id:2959038 TI - Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. JF - Nature reviews. Genetics AD - Department of Genetics, Evolution and Environment, and UCL Cancer Institute, University College London, London WC1E 6BT, UK. SN - 1471-0064 N2 - Organisms are constantly exposed to a wide range of environmental changes, including both short-term changes during their lifetime and longer-term changes across generations. Stress-related gene expression programmes, characterized by distinct transcriptional mechanisms and high levels of noise in their expression patterns, need to be balanced with growth-related gene expression programmes. A range of recent studies give fascinating insight into cellular strategies for keeping gene expression in tune with physiological needs dictated by the environment, promoting adaptation to both short- and long-term environmental changes. Not only do organisms show great resilience to external challenges, but emerging data suggest that they also exploit these challenges to fuel phenotypic variation and evolutionary innovation. AU - López-Maury, Luis AU - Marguerat, Samuel AU - Bähler, Jürg PY - 2008/07/01/ UR - http://dx.doi.org/10.1038/nrg2398 ER -