The environmental light influences the circulatory levels of retinoic acid and associates with hepatic lipid metabolism

@article{citeulike:3096613, abstract = {Environmental light is involved in the regulation of photochemical reaction in mouse retina. It remains unclear whether light-mediated increase in all-trans retinoic acid (ATRA) synthesis in retina will result in altering the circulatory levels of ATRA and regulating downstream gene expression and physiological function. Here we showed circulatory levels of ATRA decreased in mice under constant darkness and elevated by light exposure. Fat gene pancreatic lipase-related protein 2 (mPlrp2) and its partner procolipase (mClps), but not hepatic lipase (mHl), activated in livers for responding to lack of light illuminating. Light-triggered alterations in circulatory ATRA levels regulated ecto-5'-nucleotidase (Cd73) gene expression by retinoic acid receptor RARalpha and modulated 5'-adenosine monophosphate (5'-AMP) levels in blood and were associated with mPlrp2 and mClps expression in the livers. Mice deficient in adenosine receptors displayed mPlrp2 and mClps expression in livers under 12h/12h light/dark cycles. Caffeine blocked adenosine receptors and induced hepatic mPlrp2 and mClps expression in wild type mice. Mice activated in hepatic mPlrp2 and mClps expression lowered hepatic and serum lipid levels and markedly elevated circulatory levels of all-trans retinol (ATR). Our results suggest environmental light influence hepatic lipid homeostasis by light-modulated retinoic acid signaling associated with mPlrp2 and mClps gene expression in livers. 10.1210/en.2008-0562}, author = {Pang, Wenqiang and Li, Chunying and Zhao, Yue and Wang, Shiming and Dong, Wei and Jiang, Pengjiu and Zhang, Jianfa }, citeulike-article-id = {3096613}, doi = {10.1210/en.2008-0562}, journal = {Endocrinology}, keywords = {lipid\_metabolism, liver, retinoic\_acid}, month = {July}, pages = {en.2008-0562+}, posted-at = {2008-08-07 19:37:55}, priority = {2}, title = {The environmental light influences the circulatory levels of retinoic acid and associates with hepatic lipid metabolism}, url = {http://dx.doi.org/10.1210/en.2008-0562}, year = {2008} }

TY - JOUR ID - citeulike:3096613 L3 - citeulike-article-id:3096613 TI - The environmental light influences the circulatory levels of retinoic acid and associates with hepatic lipid metabolism JF - Endocrinology SP - en.2008-0562 N2 - Environmental light is involved in the regulation of photochemical reaction in mouse retina. It remains unclear whether light-mediated increase in all-trans retinoic acid (ATRA) synthesis in retina will result in altering the circulatory levels of ATRA and regulating downstream gene expression and physiological function. Here we showed circulatory levels of ATRA decreased in mice under constant darkness and elevated by light exposure. Fat gene pancreatic lipase-related protein 2 (mPlrp2) and its partner procolipase (mClps), but not hepatic lipase (mHl), activated in livers for responding to lack of light illuminating. Light-triggered alterations in circulatory ATRA levels regulated ecto-5'-nucleotidase (Cd73) gene expression by retinoic acid receptor RARalpha and modulated 5'-adenosine monophosphate (5'-AMP) levels in blood and were associated with mPlrp2 and mClps expression in the livers. Mice deficient in adenosine receptors displayed mPlrp2 and mClps expression in livers under 12h/12h light/dark cycles. Caffeine blocked adenosine receptors and induced hepatic mPlrp2 and mClps expression in wild type mice. Mice activated in hepatic mPlrp2 and mClps expression lowered hepatic and serum lipid levels and markedly elevated circulatory levels of all-trans retinol (ATR). Our results suggest environmental light influence hepatic lipid homeostasis by light-modulated retinoic acid signaling associated with mPlrp2 and mClps gene expression in livers. 10.1210/en.2008-0562 KW - lipid_metabolism KW - liver KW - retinoic_acid AU - Pang, Wenqiang AU - Li, Chunying AU - Zhao, Yue AU - Wang, Shiming AU - Dong, Wei AU - Jiang, Pengjiu AU - Zhang, Jianfa PY - 2008/07/31/ UR - http://dx.doi.org/10.1210/en.2008-0562 ER -