Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae

by: Melissa B Miller, Karen Skorupski, Derrick H Lenz, Ronald K Taylor, Bonnie L Bassler

Cell, Vol. 110, No. 3. (9 August 2002), pp. 303-314.

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quorum-sensing, vibrio-cholerae, virulence

Abstract

The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double mutants indicates that a third as yet unidentified sensory circuit exists in V. cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence.

@article{citeulike:1474031, abstract = {The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double mutants indicates that a third as yet unidentified sensory circuit exists in V. cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence.}, author = {Miller, Melissa B. and Skorupski, Karen and Lenz, Derrick H. and Taylor, Ronald K. and Bassler, Bonnie L. }, citeulike-article-id = {1474031}, journal = {Cell}, keywords = {quorum-sensing, vibrio-cholerae, virulence}, month = {August}, number = {3}, pages = {303--314}, posted-at = {2007-07-23 03:48:02}, priority = {2}, title = {Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae}, url = {http://www.sciencedirect.com/science/article/B6WSN-46H7VCR-7/2/d3e1803a751e1db5cb1f27bd279e070b}, volume = {110}, year = {2002} }

RIS record

TY - JOUR ID - citeulike:1474031 L3 - citeulike-article-id:1474031 TI - Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae JF - Cell VL - 110 IS - 3 SP - 303 EP - 314 N2 - The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double mutants indicates that a third as yet unidentified sensory circuit exists in V. cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence. KW - quorum-sensing KW - vibrio-cholerae KW - virulence AU - Miller, Melissa AU - Skorupski, Karen AU - Lenz, Derrick AU - Taylor, Ronald AU - Bassler, Bonnie PY - 2002/08/09/ UR - http://www.sciencedirect.com/science/article/B6WSN-46H7VCR-7/2/d3e1803a751e1db5cb1f27bd279e070b ER -

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