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タグ: targets [90 articles]

Recent papers classified by the tag targets.
  • Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer
    BMC Bioinformatics, Vol. 8, No. Suppl 7. (2007)
    by Yuriy Gusev, Thomas Schmittgen, Megan Lerner, Russell Postier, Daniel Brackett
    posted to cancer in microrna mirna targets by yugusev on 2007-12-16 07:14:37 as read along with 5 people jfr eckart_bindewald ealloza vinithepooh maralena
  • Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4.
    Biochim Biophys Acta, Vol. 1399, No. 2-3. (20 August 1998), pp. 181-186.
    by MJ Stewart, KM Dipple, M Estonius, H Nakshatri, LM Everett, DW Crabb
    posted to hnf4 targets by yevishere on 2008-01-03 00:00:54 as **
  • Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1.
    Adv Exp Med Biol, Vol. 463 (1999), pp. 115-121.
    by J Pinaire, WY Chou, M Stewart, K Dipple, D Crabb
    posted to hnf4 targets by yevishere on 2008-01-03 00:00:43 as **
  • Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver.
    FEBS Lett, Vol. 578, No. 1-2. (3 December 2004), pp. 63-68.
    by A Kamiya, Y Inoue, T Kodama, FJ Gonzalez
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:57:43 as **
  • Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk.
    Physiol Genomics, Vol. 29, No. 3. (11 May 2007), pp. 290-301.
    by X Li, BB Madison, W Zacharias, A Kolterud, D States, DL Gumucio
    posted to hnf4 intestine targets by yevishere on 2008-01-03 23:26:06 as **
  • The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene.
    EMBO J, Vol. 11, No. 2. (February 1992), pp. 433-439.
    by JD Tugwood, I Issemann, RG Anderson, KR Bundell, WL McPheat, S Green
    posted to hnf4 targets by yevishere on 2008-01-03 00:00:32 as ** along with 1 person ea
  • The human intestinal fatty acid binding protein (hFABP2) gene is regulated by HNF-4[alpha]
    Biochemical and Biophysical Research Communications, Vol. 356, No. 1. (27 April 2007), pp. 147-152.
    by Maja Klapper, Mike Bohme, Inke Nitz, Frank Doring
    posted to hnf4 targets by yevishere on 2008-01-03 23:25:24 as **
  • An array of binding sites for hepatocyte nuclear factor 4 of high and low affinities modulates the liver-specific enhancer for the human alpha1-microglobulin/bikunin precursor.
    Biochem J, Vol. 334 ( Pt 3) (15 September 1998), pp. 577-584.
    by P Rouet, G Raguenez, P Ruminy, JP Salier
    posted to hnf4 targets by yevishere on 2008-01-03 00:00:14 as **
  • Hierarchy and positive/negative interplays of the hepatocyte nuclear factors HNF-1, -3 and -4 in the liver-specific enhancer for the human alpha-1-microglobulin/bikunin precursor.
    Nucleic Acids Res, Vol. 23, No. 3. (11 February 1995), pp. 395-404.
    by P Rouet, G Raguenez, F Tronche, V Mfou'ou, JP Salier
    posted to hnf4 targets by yevishere on 2008-01-02 23:59:59 as **
  • RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain.
    Mol Pharmacol, Vol. 67, No. 3. (March 2005), pp. 604-611.
    by M Niehof, J Borlak
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:57:27 as **
  • The peroxisome proliferator response element (PPRE) present at positions -681/-669 in the rat liver 3-ketoacyl-CoA thiolase B gene functionally interacts differently with PPARalpha and HNF-4.
    Biochem Biophys Res Commun, Vol. 269, No. 2. (16 March 2000), pp. 347-351.
    by V Nicolas-Frances, VK Dasari, E Abruzzi, T Osumi, N Latruffe
    posted to hnf4 targets by yevishere on 2008-01-02 23:59:46 as **
  • The hepatocyte nuclear factor 4 (HNF-4) represses the mitochondrial HMG-CoA synthase gene.
    Biochem Biophys Res Commun, Vol. 242, No. 3. (26 January 1998), pp. 692-696.
    by JC Rodríguez, JA Ortiz, FG Hegardt, D Haro
    posted to hnf4 targets by yevishere on 2008-01-02 23:59:33 as **
  • The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.
    J Pharmacol Exp Ther, Vol. 317, No. 2. (May 2006), pp. 778-785.
    by M Saborowski, GA Kullak-Ublick, JJ Eloranta
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:53:22 as **
  • Comparative genomics and experimental promoter analysis reveal functional liver-specific elements in mammalian hepatic lipase genes
    BMC Genomics, Vol. 8 (11 April 2007), 99.
    by Diederik van Deursen, Gert-Jan Botma, Hans Jansen, Adrie JM Verhoeven
    posted to genomics hnf4 mining targets by yevishere on 2008-01-03 23:20:00 as **** along with 1 group VUMCGenomics
  • Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms.
    Hepatology, Vol. 45, No. 5. (May 2007), pp. 1146-1153.
    by JM Pascussi, A Robert, A Moreau, J Ramos, P Bioulac-Sage, F Navarro, P Blanc, E Assenat, P Maurel, MJ Vilarem
    posted to hnf4 isoforms targets by yevishere on 2008-01-03 23:18:02 as **
  • The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.
    J Lipid Res, Vol. 48, No. 8. (August 2007), pp. 1781-1791.
    by B Dongol, Y Shah, I Kim, FJ Gonzalez, MC Hunt
    posted to hnf4 targets by yevishere on 2008-01-03 23:16:16 as **
  • Differentiation of neonatal rat epithelial cells from biliary origin into immature hepatic cells by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development.
    Toxicol In Vitro, Vol. 21, No. 7. (October 2007), pp. 1325-1331.
    by S Snykers, J De Kock, T Vanhaecke, V Rogiers
    posted to hnf4 targets toxicology by yevishere on 2008-01-03 23:15:20 as **
  • The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells.
    J Biol Chem, Vol. 282, No. 31. (3 August 2007), pp. 22638-22650.
    by N Jonckheere, A Vincent, M Perrais, MP Ducourouble, AK Male, JP Aubert, P Pigny, KL Carraway, JN Freund, IB Renes, I Van Seuningen
    posted to hnf4 targets by yevishere on 2008-01-03 23:10:45 as **
  • Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.
    Mol Endocrinol, Vol. 21, No. 11. (November 2007), pp. 2698-2712.
    by B Ponugoti, S Fang, JK Kemper
    posted to hnf4 interactions targets by yevishere on 2008-01-02 23:47:19 as **
  • Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha.
    Am J Physiol Gastrointest Liver Physiol, Vol. 293, No. 3. (September 2007)
    by CG Dietrich, IV Martin, AC Porn, S Voigt, C Gartung, C Trautwein, A Geier
    posted to bileacids fasting hnf4 targets by yevishere on 2008-01-02 23:46:35 as **
  • Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
    J Pharmacol Exp Ther, Vol. 323, No. 2. (November 2007), pp. 586-598.
    by HL Fang, SC Strom, E Ellis, Z Duanmu, J Fu, Z Duniec-Dmuchowski, CN Falany, JL Falany, TA Kocarek, M Runge-Morris
    posted to hnf4 targets by yevishere on 2008-01-02 23:43:33 as **
  • The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
    Biochem J, Vol. 409, No. 1. (1 January 2008), pp. 243-250.
    by FJ Liu, X Song, D Yang, R Deng, B Yan
    posted to hnf4 targets by yevishere on 2008-01-02 23:41:38 as **
  • Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Drug Metab Dispos, Vol. 34, No. 5. (May 2006), pp. 756-764.
    by T Li, JY Chiang
    posted to hnf4 interactions targets by yevishere on 2008-01-02 23:38:02 as **
  • Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA.
    Drug Metab Pharmacokinet, Vol. 22, No. 4. (August 2007), pp. 287-298.
    by Y Kamiyama, T Matsubara, K Yoshinari, K Nagata, H Kamimura, Y Yamazoe
    posted to hnf4 microarray targets by yevishere on 2008-01-02 23:36:13 as **
  • Nuclear Receptor Hepatocyte Nuclear Factor 4alpha1 Competes with Oncoprotein c-Myc for Control of the p21/WAF1 Promoter.
    Mol Endocrinol, Vol. 22, No. 1. (January 2008), pp. 78-90.
    by WW Hwang-Verslues, FM Sladek
    posted to hnf4 interactions targets by yevishere on 2008-01-02 23:33:38 as **
  • Hepatocyte nuclear factor 1 alpha and 4 alpha are factors involved in interindividual variability in the expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in human livers.
    Drug Metab Pharmacokinet, Vol. 22, No. 5. (October 2007), pp. 391-398.
    by S Aueviriyavit, T Furihata, K Morimoto, K Kobayashi, K Chiba
    posted to hnf4 targets by yevishere on 2008-01-02 23:27:51 as **
  • Regulation of human protein Z gene expression by liver-enriched transcription factor HNF-4 and ubiquitous factor Sp1
    Journal of Thrombosis and Haemostasis, Vol. 5, No. 11. (November 2007), pp. 2250-2258.
    by H Sugawara, H Iwata, M Souri, A Ichinose
    posted to hnf4 targets by yevishere on 2008-01-02 23:27:33 as **
  • Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of HNF4alpha to the proximal promoter.
    Mol Pharmacol (31 October 2007)
    by Tania Onica, Kathleen Nichols, Meghan Larin, Lorraine Ng, Ann Maslen, Zdenek Dvorak, Jean-Marc M Pascussi, Marie-Josee J Vilarem, Patrick Maurel, Gordon Kirby
    posted to hnf4 targets by yevishere on 2008-01-02 23:26:28 as **
  • EXPRESSION OF THE HEPATIC SPECIFIC V1 mRNA OF THE HUMAN GROWTH HORMONE RECEPTOR GENE IS REGULATED BY HNF-4alpha2 and HNF-4alpha8.
    Mol Endocrinol (8 November 2007)
    by Cynthia Gates G Goodyer, Zakaria Rhani, Hong Zheng
    posted to hnf4 targets by yevishere on 2008-01-02 23:25:53 as **
  • Hepatic HNF4alpha deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes.
    Hepatology, Vol. 45, No. 2. (February 2007), pp. 433-444.
    by VS Stanulović, I Kyrmizi, M Kruithof-de Julio, M Hoogenkamp, JL Vermeulen, JM Ruijter, I Talianidis, TB Hakvoort, WH Lamers
    posted to expression hnf4 targets by yevishere on 2008-01-03 23:27:20 as **
  • Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor.
    J Biol Chem, Vol. 274, No. 49. (3 December 1999), pp. 34605-34612.
    by K Yanai, K Hirota, K Taniguchi-Yanai, Y Shigematsu, Y Shimamoto, T Saito, S Chowdhury, M Takiguchi, M Arakawa, Y Nibu, F Sugiyama, K Yagami, A Fukamizu
    posted to hnf4 targets by yevishere on 2008-01-03 00:01:04 as **
  • HNF4alpha is a Crucial Modulator of the Cholesterol-Dependent Regulation of NPC1L1.
    Pharm Res (14 December 2007)
    by Yuki Iwayanagi, Tappei Takada, Hiroshi Suzuki
    posted to hnf4 targets by yevishere on 2008-01-02 23:12:06 as **
  • Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha.
    J Lipid Res, Vol. 47, No. 11. (November 2006), pp. 2503-2514.
    by EA Hanniman, G Lambert, Y Inoue, FJ Gonzalez, CJ Sinal
    posted to hnf4 targets by yevishere on 2008-01-03 23:35:41 as **
  • Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.
    Arch Biochem Biophys, Vol. 362, No. 1. (1 February 1999), pp. 32-37.
    by M Ogino, K Nagata, M Miyata, Y Yamazoe
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:09:21 as **
  • Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family.
    J Biol Chem, Vol. 271, No. 41. (11 October 1996), pp. 25269-25276.
    by W Cairns, CA Smith, AW McLaren, CR Wolf
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:09:12 as **
  • Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions.
    Biochemistry, Vol. 34, No. 25. (27 June 1995), pp. 8028-8036.
    by GC Ibeanu, JA Goldstein
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:09:00 as **
  • A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4.
    J Biol Chem, Vol. 269, No. 7. (18 February 1994), pp. 5420-5427.
    by D Chen, G Lepar, B Kemper
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:08:43 as **
  • Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes.
    DNA Cell Biol, Vol. 13, No. 7. (July 1994), pp. 771-779.
    by D Chen, Y Park, B Kemper
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:06:47 as **
  • Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.
    J Steroid Biochem Mol Biol, Vol. 62, No. 4. (July 1997), pp. 307-314.
    by N Yokomori, K Nishio, K Aida, M Negishi
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:06:26 as **
  • The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.
    J Biol Chem, Vol. 269, No. 2. (14 January 1994), pp. 890-902.
    by H Nakshatri, P Chambon
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:06:14 as **
  • Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas.
    Eur J Biochem, Vol. 223, No. 2. (15 July 1994), pp. 529-541.
    by W Hauck, P Nédellec, C Turbide, CP Stanners, TR Barnett, N Beauchemin
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:06:04 as **
  • Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to the proximal promoter and distal enhancer sites.
    Arterioscler Thromb Vasc Biol, Vol. 17, No. 1. (January 1997), pp. 222-232.
    by D Kardassis, I Tzameli, M Hadzopoulou-Cladaras, I Talianidis, V Zannis
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:05:55 as **
  • The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers.
    Biochim Biophys Acta, Vol. 1348, No. 3. (18 October 1997), pp. 299-310.
    by L Vergnes, T Taniguchi, K Omori, MM Zakin, A Ochoa
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:05:48 as **
  • HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression.
    Biochim Biophys Acta, Vol. 1759, No. 8-9. (p 2006), pp. 426-436.
    by V Douet, CM VanWart, MB Heller, S Reinhard, O Le Saux
    posted to hnf4 targets by yevishere on 2008-01-03 23:31:47 as **
  • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
    Genes Dev, Vol. 4, No. 12B. (December 1990), pp. 2353-2365.
    by FM Sladek, WM Zhong, E Lai, JE Darnell
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:05:32 as **
  • Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.
    J Biol Chem, Vol. 273, No. 28. (10 July 1998), pp. 17810-17816.
    by D Kardassis, E Sacharidou, VI Zannis
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:05:19 as **
  • Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine.
    J Biol Chem, Vol. 275, No. 34. (25 August 2000), pp. 26637-26648.
    by TJ Antes, SA Goodart, C Huynh, M Sullivan, SG Young, B Levy-Wilson
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:05:07 as **
  • Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription.
    J Biol Chem, Vol. 268, No. 22. (5 August 1993), pp. 16831-16838.
    by S Metzger, JL Halaas, JL Breslow, FM Sladek
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:04:53 as **
  • Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene.
    Nucleic Acids Res, Vol. 22, No. 22. (11 November 1994), pp. 4689-4696.
    by E Ktistaki, JM Lacorte, N Katrakili, VI Zannis, I Talianidis
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:04:41 as **
  • Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.
    J Biol Chem, Vol. 267, No. 22. (5 August 1992), pp. 15849-15860.
    by JA Ladias, M Hadzopoulou-Cladaras, D Kardassis, P Cardot, J Cheng, V Zannis, C Cladaras
    posted to hnf4 s1a targets by yevishere on 2008-01-03 00:04:29 as **
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