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タグ: ligands [115 articles]

Recent papers classified by the tag ligands.
  • Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1.
    J Mol Biol, Vol. 364, No. 4. (8 December 2006), pp. 567-581.
    by J Eeckhoute, I Briche, M Kurowska, P Formstecher, B Laine
    posted to hnf4 ligands pancreas by yevishere on 2008-01-03 23:29:59 as *****
  • Role of Fatty Acid Binding Proteins and Long Chain Fatty Acids in Modulating Nuclear Receptors and Gene Transcription.
    Lipids (19 September 2007)
    by Friedhelm Schroeder, Anca D Petrescu, Huan Huang, Barbara P Atshaves, Avery L McIntosh, Gregory G Martin, Heather A Hostetler, Aude Vespa, Danilo Landrock, Kerstin K Landrock, H R Payne, Ann B Kier
    posted to hnf4 ligands review by yevishere on 2008-01-02 23:34:31 as **
  • Regulation of human hepatocyte gene expression by fatty acids.
    Biochem Biophys Res Commun, Vol. 362, No. 2. (19 October 2007), pp. 374-380.
    by CD Swagell, DC Henly, CP Morris
    posted to fattyacid hnf4 ligands by yevishere on 2008-01-02 23:42:40 as **
  • A chemogenomic analysis of the transmembrane binding cavity of human G-protein-coupled receptors.
    Proteins, Vol. 62, No. 2. (1 February 2006), pp. 509-538.
    by JS Surgand, J Rodrigo, E Kellenberger, D Rognan
    posted to binding gpcr ligands transmembrane by xdeupi on 2006-03-01 16:33:01 as ***** along with 1 group LabCompMed
  • Subclassification and nomenclature of alpha- and beta-adrenoceptors.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 129-134.
    by JP Hieble
    posted to agonist b2ar drug genome ligands pharmacology review by xdeupi on 2007-03-12 14:33:19 as ** along with 1 group LabCompMed
  • Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism.
    J Biomol Screen, Vol. 12, No. 1. (February 2007), pp. 41-49.
    by L Elster, C Elling, A Heding
    posted to activation agonist b2ar fret ligands by xdeupi on 2007-04-10 18:50:15 as ** along with 1 group LabCompMed
  • Molecular evolution of adrenoceptors and dopamine receptors: implications for the binding of catecholamines.
    J Med Chem, Vol. 49, No. 5. (9 March 2006), pp. 1706-1719.
    by H Xhaard, VV Rantanen, T Nyrönen, MS Johnson
    posted to agonist b2ar binding gpcr ligands modeling by xdeupi on 2006-03-06 10:11:30 as **** along with 1 group LabCompMed
  • Chemogenomic approaches to rational drug design
    Br J Pharmacol, Vol. 152, No. 1. (29 May 2007), pp. 38-52.
    by D Rognan
    posted to agonist binding drug ligands pharmacology priviledged_structures by xdeupi on 2008-03-28 15:54:47 as ** along with 4 people and 3 groups jmrivort jerome_ucsf_slb jyuh tjimenez LabCompMed G-quadruplex Supramolecular
  • GPCR agonists and antagonists in the clinic.
    Med Chem, Vol. 1, No. 4. (July 2005), pp. 405-421.
    by JD Tyndall, R Sandilya
    posted to agonist drug gpcr ligands pharmacology by xdeupi on 2006-07-24 10:18:01 as ** along with 1 group LabCompMed
  • "Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology.
    Biochem Pharmacol, Vol. 73, No. 6. (15 March 2007), pp. 737-751.
    by CP Nelson, RA Challiss
    posted to agonist gpcr ligands pharmacology by xdeupi on 2007-04-10 18:54:26 as ** along with 1 person and 2 groups Fritz neurolit LabCompMed
  • Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
    J Pharmacol Exp Ther (20 July 2006)
    by Terry P P Kenakin, Stephen Jenkinson, Christian Watson
    posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as **** along with 1 group LabCompMed
  • Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.
    Mol Pharmacol, Vol. 62, No. 1. (July 2002), pp. 15-21.
    by ML López-Rodríguez, B Vicente, X Deupi, S Barrondo, M Olivella, MJ Morcillo, B Behamú, JA Ballesteros, J Sallés, L Pardo
    posted to 5ht1a ligands by xdeupi on 2005-10-25 03:16:43 as read along with 1 group LabCompMed
  • Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor.
    J Biol Chem, Vol. 280, No. 41. (14 October 2005), pp. 34849-34858.
    by SJ Han, FF Hamdan, SK Kim, KA Jacobson, LM Bloodworth, B Li, J Wess
    posted to ligands cation-pi binding agonist by xdeupi on 2007-01-15 16:08:15 as ** along with 1 group LabCompMed
  • The Cationminus signpi Interaction.
    Chem Rev, Vol. 97, No. 5. (5 August 1997), pp. 1303-1324.
    by Jennifer C Ma, Dennis A Dougherty
    posted to trp ligands histamine cation-pi binding b2ar by xdeupi on 2007-01-11 14:28:54 as ** along with 1 group LabCompMed
  • Data-Driven Analysis in Drug Discovery
    Journal of Receptors and Signal Transduction, Vol. 26, No. 4. (August 2006), pp. 299-327.
    by Terry Kenakin
    posted to agonist binding drug ligands pharmacology by xdeupi on 2006-07-17 16:28:05 as **** along with 1 group LabCompMed
  • Chromophore Channeling in the G-Protein Coupled Receptor Rhodopsin.
    J Am Chem Soc (15 May 2007)
    by Ting Wang, Yong Duan
    posted to activation agonist amber binding ligands md modeling rhodopsin by xdeupi on 2007-05-21 10:04:04 as ***** along with 1 group LabCompMed
  • I want a new drug: G-protein-coupled receptors in drug development.
    Drug Discov Today, Vol. 11, No. 11-12. (June 2006), pp. 481-493.
    by S Schlyer, R Horuk
    posted to drug gpcr ligands pharmacology review by xdeupi on 2006-11-04 12:41:53 as ** along with 1 group LabCompMed
  • notes Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.
    J Biol Chem, Vol. 274, No. 31. (30 July 1999), pp. 21867-21872.
    by A Marjamäki, H Frang, M Pihlavisto, AM Hoffrén, T Salminen, MS Johnson, J Kallio, JA Javitch, M Scheinin
    posted to activation binding cys_scanning drug ligands tm5 by xdeupi on 2008-03-07 15:14:37 as ** along with 1 group LabCompMed
  • New concepts in drug discovery: collateral efficacy and permissive antagonism.
    Nat Rev Drug Discov, Vol. 4, No. 11. (November 2005), pp. 919-927.
    by T Kenakin
    posted to activation agonist ccr5 gpcr ligands by xdeupi on 2005-11-04 21:57:24 as ** along with 1 group LabCompMed
  • A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
    Proc Natl Acad Sci U S A, Vol. 103, No. 30. (25 July 2006), pp. 11288-11293.
    by SB Liggett, J Mialet-Perez, S Thaneemit-Chen, SA Weber, SM Greene, D Hodne, B Nelson, J Morrison, MJ Domanski, LE Wagoner, WT Abraham, JL Anderson, JF Carlquist, HJ Krause-Steinrauf, LC Lazzeroni, JD Port, PW Lavori, MR Bristow
    posted to b2ar disease drug genome helix8 ligands polymorphism by xdeupi on 2006-09-05 11:38:25 as ** along with 1 group LabCompMed
  • Recent advances in identification and characterization of beta-adrenoceptor agonists and antagonists.
    Curr Top Med Chem, Vol. 7, No. 2. (2007), pp. 207-216.
    by JP Hieble
    posted to agonist b2ar drug ligands pharmacology by xdeupi on 2007-03-12 14:32:04 as ** along with 1 group LabCompMed
  • Drugs, their targets and the nature and number of drug targets
    Nature Reviews Drug Discovery, Vol. 5, No. 10., pp. 821-834.
    by Peter Imming, Christian Sinning, Achim Meyer
    posted to review ligands gpcr genome drug by xdeupi on 2007-01-22 17:55:08 as ** along with 4 people and 1 group kuhn massivemayhem Ao_Li2007 yaredo LabCompMed
  • Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV and -VI.
    Mol Pharmacol (14 December 2006)
    by Mette M M Rosenkilde, Michael B B Andersen, Rie Nygaard, Thomas M M Frimurer, Thue W W Schwartz
    posted to ligands ionic chemokine cation-pi agonist activation by xdeupi on 2007-01-11 16:06:35 as ** along with 1 group LabCompMed
  • Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.
    J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691.
    by G Swaminath, Y Xiang, TW Lee, J Steenhuis, C Parnot, BK Kobilka
    posted to activation agonist b2ar binding ligands tm6 by xdeupi on 2005-12-16 10:19:18 as read along with 1 person and 1 group jddowney LabCompMed
  • Modeling and active site refinement for G protein-coupled receptors: application to the beta-2 adrenergic receptor.
    J Comput Aided Mol Des (13 October 2006)
    by Stanley R Krystek, S R Kimura, Andrew J Tebben
    posted to b2ar binding drug ligands modeling pharmacology by xdeupi on 2006-10-27 09:43:03 as ** along with 1 person and 1 group daevans LabCompMed
  • Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.
    J Biol Chem (25 June 2007)
    by Vimesh A A Avlani, Karen J J Gregory, Craig J J Morton, Michael W W Parker, Patrick M M Sexton, Arthur Christopoulos
    posted to activation binding ecl2 ligands loops structure by xdeupi on 2007-06-29 21:12:42 as ** along with 1 group LabCompMed
  • GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors.
    Curr Top Med Chem, Vol. 6, No. 13. (2006), pp. 1319-1333.
    by MM Rosenkilde, TW Schwartz
    posted to modeling ligands ionic chemokine binding agonist by xdeupi on 2007-01-10 14:45:13 as ** along with 1 group LabCompMed
  • Changes in interhelical hydrogen bonding upon rhodopsin activation.
    J Mol Biol, Vol. 347, No. 4. (8 April 2005), pp. 803-812.
    by AB Patel, E Crocker, PJ Reeves, EV Getmanova, M Eilers, HG Khorana, SO Smith
    posted to activation b2ar binding hbond helix ligands nmr pro-kink rhodopsin ser structure switch tm5 tm6 toggle by xdeupi on 2006-06-01 13:51:11 as read along with 1 group LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • beta-Arrestin-biased Agonism at the beta2-Adrenergic Receptor.
    J Biol Chem, Vol. 283, No. 9. (29 February 2008), pp. 5669-5676.
    by MT Drake, JD Violin, EJ Whalen, JW Wisler, SK Shenoy, RJ Lefkowitz
    posted to activation agonist arrestin b2ar biased_agonism drug gproteins imaging internalization ligands pharmacology by xdeupi on 2008-02-27 10:39:07 as *** along with 1 group LabCompMed
  • The identification of ligands at orphan G-protein coupled receptors.
    Annu Rev Pharmacol Toxicol, Vol. 44 (2004), pp. 43-66.
    by A Wise, SC Jupe, S Rees
    posted to drug gpcr ligands by xdeupi on 2006-03-01 16:35:26 as ** along with 1 group LabCompMed
  • Interactions with Aromatic Rings in Chemical and Biological Recognition
    Angewandte Chemie International Edition, Vol. 42, No. 11. (13 March 2003), pp. 1210-1250.
    by Emmanuel A Meyer, Dipl, Ronald K Castellano, Dr, François Diederich, Dr
    posted to comt ligands receptors by softsimu on 2007-12-12 18:46:24 as ** along with 1 person diquesto
  • Candidates for peptide receptor radiotherapy today and in the future.
    J Nucl Med, Vol. 46 Suppl 1 (January 2005)
    by JC Reubi, HR Mäcke, EP Krenning
    posted to ligands peptides by smather on 2005-05-03 15:47:31 as ***
  • Correlated motion and the effect of distal mutations in dihydrofolate reductase.
    Proc Natl Acad Sci U S A, Vol. 100, No. 12. (10 June 2003), pp. 6980-6985.
    by TH Rod, JL Radkiewicz, CL Brooks
    posted to binding catalysis chemistry dhfr enzyme ligands md motion mutations protein simulation by ruvido on 2006-12-21 14:20:49 as **
  • Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.
    Biochem J, Vol. 394, No. Pt 1. (15 February 2006), pp. 259-265.
    by RS Swanwick, G Maglia, LH Tey, RK Allemann
    posted to binding catalysis dhfr enzyme kinetics ligands motion nmr transition by ruvido on 2006-12-21 14:18:38 as **
  • Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations.
    Philos Trans R Soc Lond B Biol Sci, Vol. 361, No. 1472. (29 August 2006), pp. 1365-1373.
    by S Hammes-Schiffer, JB Watney
    posted to binding catalysis chemistry dhfr enzyme kinetics ligands mutations qmm review simulation by ruvido on 2006-12-21 14:27:31 as **
  • Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.
    Proc Natl Acad Sci U S A, Vol. 102, No. 19. (10 May 2005), pp. 6807-6812.
    by KF Wong, T Selzer, SJ Benkovic, S Hammes-Schiffer
    posted to binding catalysis chemistry dhfr enzyme kinetics ligands md motion mutations simulation by ruvido on 2006-12-21 14:23:16 as **
  • Perspectives of biomolecular NMR in drug discovery: the blessing and curse of versatility
    Journal of Biomolecular NMR, Vol. 39, No. 2. (20 October 2007), pp. 87-90.
    by Wolfgang Jahnke
    posted to ligands review screening by rph on 2008-03-27 05:38:21 as **
  • Micelles. Physical chemistry of surfactant association
    Physics Reports, Vol. 52, No. 1. (April 1979), pp. 1-86.
    by Håkan Wennerström, Björn Lindman
    posted to detergents ligands micelles theory by rph on 2008-05-19 19:22:44 as **
  • A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase
    Proceedings of the National Academy of Sciences, Vol. 104, No. 21. (22 May 2007), pp. 8815-8820.
    by Algirdas Velyvis, Ying R Yang, Howard K Schachman, Lewis E Kay
    posted to biggies dynamics ligands methyl relaxation trosy by rph on 2008-05-23 23:09:44 as **
  • Autocrine, paracrine and juxtacrine signaling by EGFR ligands
    Cellular Signalling, Vol. 17, No. 10. (October 2005), pp. 1183-1193.
    by Amar B Singh, Raymond C Harris
    posted to ligands review by pjasper on 2007-04-18 19:22:43 as **
  • High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor.
    Cancer Res, Vol. 65, No. 24. (15 December 2005), pp. 11478-11485.
    by N Fujimoto, M Wislez, J Zhang, K Iwanaga, J Dackor, AE Hanna, S Kalyankrishna, DD Cody, RE Price, M Sato, JW Shay, JD Minna, M Peyton, X Tang, E Massarelli, R Herbst, DW Threadgill, II Wistuba, JM Kurie
    posted to erbb2 erbb3 iressa ligands by pjasper on 2007-04-19 19:42:05 as **
  • A New Method to Detect Related Function Among Proteins Independent of Sequence and Fold Homology
    Journal of Molecular Biology, Vol. 323, No. 2. (18 October 2002), pp. 387-406.
    by Stefan Schmitt, Daniel Kuhn, Gerhard Klebe
    posted to binding-site ligands by massivemayhem on 2008-02-07 10:28:07 as **
  • SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands.
    Biomol Eng, Vol. 24, No. 4. (October 2007), pp. 381-403.
    by R Stoltenburg, C Reinemann, B Strehlitz
    posted to affinity aptamer dna evolution ligands molecular oligonucleotide polymerase protein proteomics research rna science selection selex by jonathanjacobs on 2008-05-14 18:48:28 as read along with 1 person jyuh
  • Diversity of Oligonucleotide Functions
    Annual Review of Biochemistry, Vol. 64, No. 1. (1995), pp. 763-797.
    by L Gold, B Polisky, O Uhlenbeck, M Yarus
    posted to dna ligands oligonucleotide protein rna selex structure by jonathanjacobs on 2008-06-23 16:20:18 as **
  • notes Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands.
    Bioorg Med Chem Lett, Vol. 16, No. 5. (1 March 2006), pp. 1255-1258.
    by P Raubo, MS Beer, PA Hunt, IT Huscroft, C London, JA Stanton, JJ Kulagowski
    posted to 5ht7 ligands by jessicaopacic on 2006-11-07 15:04:07 as *** along with 1 group LabCompMed
  • Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.
    Immunity, Vol. 12, No. 6. (June 2000), pp. 721-727.
    by A Cerwenka, AB Bakker, T McClanahan, J Wagner, J Wu, JH Phillips, LL Lanier
    posted to identification ligands nkg2d rae by isera on 2007-07-12 21:32:48 as ** along with 1 person AlfonsoVicenteSuarez
  • Expression of the stress-related MHC class I chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients.
    Int J Cancer, Vol. 118, No. 6. (15 March 2006), pp. 1445-1452.
    by NF Watson, I Spendlove, Z Madjd, R McGilvray, AR Green, IO Ellis, JH Scholefield, LG Durrant
    posted to colorectal expression immunity ligands mica nkg2d tumor by isera on 2007-07-13 23:37:20 as **
  • Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.
    Proc Natl Acad Sci U S A, Vol. 93, No. 22. (29 October 1996), pp. 12445-12450.
    by V Groh, S Bahram, S Bauer, A Herman, M Beauchamp, T Spies
    posted to expression heatshock ligands mic mica micb nkg2d pattern stress by isera on 2007-07-14 00:29:40 as **
  • NKG2D-independent suppression of T cell proliferation by H60 and MICA.
    Proc Natl Acad Sci U S A, Vol. 102, No. 33. (16 August 2005), pp. 11805-11810.
    by AK Kriegeskorte, FE Gebhardt, S Porcellini, M Schiemann, C Stemberger, TJ Franz, KM Huster, LN Carayannopoulos, WM Yokoyama, M Colonna, AG Siccardi, S Bauer, DH Busch
    posted to gedruckt h60 ligands lymphocyte mic mica nk nkg2d suppression tcell tumor by isera on 2007-07-03 20:53:45 as **
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