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タグ: kinases [60 articles]

Recent papers classified by the tag kinases.
  • Combining chemical genetics and proteomics to identify protein kinase substrates
    PNAS, Vol. 102, No. 50. (13 December 2005), pp. 17940-17945.
    by Noah Dephoure, Russell W Howson, Justin D Blethrow, Kevan M Shokat, Erin K O'Shea
    posted to chemical genetics kinases phosphorylation proteomics substrates by wvalleng on 2006-04-26 14:48:46 as *** along with 2 people and 1 group brant anwazo EisenLab
  • Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
    Nature (11 May 2005)
    by Lucas Pelkmans, Eugenio Fava, Hannes Grabner, Michael Hannus, Bianca Habermann, Eberhard Krausz, Marino Zerial
    posted to caveolae clathrin endocytosis kinases kinome by tsjipko on 2006-09-20 14:08:24 as ****
  • Classifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex.
    Proteins (1 October 2007)
    by Marc D D Jacobs, Paul R R Caron, Brian J J Hare
    posted to kinases by skoddet on 2008-04-11 10:43:42 as ** along with 1 person bicko
  • Evolution of signal transduction by gene and genome duplication in fish
    Journal of Structural and Functional Genomics, Vol. 3, No. 1. (1 March 2003), pp. 139-150.
    by Jean-Nicolas Volff, Manfred Schartl
    posted to duplication genome kinases tyrosine by signalduplication on 2007-11-02 23:09:19 as **
  • Defining memories by their distinct molecular traces
    Trends in Neurosciences, Vol. 31, No. 4. (April 2008), pp. 170-175.
    by Wayne S Sossin
    posted to memory kinases consolidation by sekulerlab on 2008-05-19 19:00:02 as ** along with 1 group VisionLab
  • Activated signal transduction kinases frequently occupy target genes.
    Science, Vol. 313, No. 5786. (28 July 2006), pp. 533-536.
    by DK Pokholok, J Zeitlinger, NM Hannett, DB Reynolds, RA Young
    posted to kinases signalling yeast by nickluscombe on 2006-08-01 14:15:11 as ** along with 1 group EBI-regulation
  • Structural and Functional Diversity of the Microbial Kinome.
    PLoS Biol, Vol. 5, No. 3. (13 March 2007)
    by Natarajan Kannan, Susan S S Taylor, Yufeng Zhai, J Craig C Venter, Gerard Manning
    posted to gos kinases metagenomics by michC on 2007-05-18 23:47:45 as read along with 3 people renatomilani jmeppley neils
  • An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic.
    J Clin Invest, Vol. 117, No. 12. (December 2007), pp. 4044-4054.
    by A Fernández, A Sanguino, Z Peng, E Ozturk, J Chen, A Crespo, S Wulf, A Shavrin, C Qin, J Ma, J Trent, Y Lin, HD Han, LS Mangala, JA Bankson, J Gelovani, A Samarel, W Bornmann, AK Sood, G Lopez-Berestein
    posted to desolvation drug-design imatinib kinases water by massivemayhem on 2008-02-05 14:41:58 as **
  • Calmodulin-binding protein kinases in plants.
    Trends Plant Sci, Vol. 8, No. 3. (March 2003), pp. 123-127.
    by L Zhang, YT Lu
    posted to calcium calmodulin kinases lab plants review signalling by imouthesmp on 2006-01-12 07:55:57 as ****
  • Inflammation-activated Protein Kinases as Targets for Drug Development
    Proc Am Thorac Soc, Vol. 2, No. 4. (1 November 2005), pp. 386-390.
    by Michael Karin
    posted to inflammation kinases myseminar by imouthesmp on 2006-04-12 18:49:19 as **
  • The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases).
    J Biol Chem, Vol. 272, No. 12. (21 March 1997), pp. 7727-7731.
    by H Wesche, C Korherr, M Kracht, W Falk, K Resch, MU Martin
    posted to interleukin kinases signaling by imouthesmp on 2006-04-24 19:03:55 as **
  • Induced Disorder in Protein-Ligand Complexes as a Drug-Design Strategy.
    Mol Pharm (16 February 2008)
    by Alejandro Crespo, Ariel Fernández
    posted to 2008 disorder flexibility kinases xf by higueruelo on 2008-02-19 22:53:03 as *** along with 1 person dmobley
  • Identification of novel allosteric regulators of human-erythrocyte pyruvate kinase.
    Chem Biodivers, Vol. 4, No. 11. (November 2007), pp. 2603-2617.
    by SS Kharalkar, GS Joshi, FN Musayev, M Fornabaio, DJ Abraham, MK Safo
    posted to 2007 allosteric kinases sm xf by higueruelo on 2008-01-19 11:09:02 as ***
  • Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib
    J. Biol. Chem., Vol. 283, No. 26. (27 June 2008), pp. 18292-18302.
    by Navratna Vajpai, Andre Strauss, Gabriele Fendrich, Sandra W Cowan-Jacob, Paul W Manley, Stephan Grzesiek, Wolfgang Jahnke
    posted to kinases flexibility dynamics abl 2008 by higueruelo on 2008-06-24 18:44:18 as **
  • Protein-protein interactions in the allosteric regulation of protein kinases
    Current Opinion in Structural Biology, Vol. 16, No. 6. (December 2006), pp. 702-709.
    by Patricia Pellicena, John Kuriyan
    posted to 2006 allosteric kinases ppi by higueruelo on 2007-12-21 10:46:20 as ** along with 2 people lna choonpeng
  • A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding.
    Drug Discov Today, Vol. 12, No. 15-16. (August 2007), pp. 622-633.
    by Marie A A Bogoyevitch, David P P Fairlie
    posted to 2007 allosteric kinases by higueruelo on 2008-02-22 17:32:53 as ** along with 2 people xtizon bicko
  • Kinase packing defects as drug targets.
    Drug discovery today, Vol. 12, No. 21-22. (November 2007), pp. 917-923.
    by A Crespo, A Fernández
    posted to sm kinases dehydrons 2007 by higueruelo on 2008-07-17 11:52:03 as **
  • The CK2alpha/CK2beta Interface of Human Protein Kinase CK2 Harbors a Binding Pocket for Small Molecules.
    Chem Biol, Vol. 15, No. 2. (February 2008), pp. 111-117.
    by J Raaf, E Brunstein, OG Issinger, K Niefind
    posted to 2008 allosteric flexibility kinases sm xf by higueruelo on 2008-03-20 16:52:44 as ***
  • Protein-Ligand Docking Accounting for Receptor Side Chain and Global Flexibility in Normal Modes: Evaluation on Kinase Inhibitor Cross Docking
    J. Med. Chem., Vol. 51, No. 12. (26 June 2008), pp. 3499-3506.
    by Andreas May, Martin Zacharias
    posted to sm-prot nma kinases docking 2008 by higueruelo on 2008-06-19 10:21:14 as **
  • Molecular basis for specificity in the druggable kinome: sequence-based analysis
    Bioinformatics, Vol. 23, No. 5. (March 2007), pp. 563-572.
    by Chen, Jianping, Zhang, Xi
    posted to protein_structure kinases hbond dehydron by barry to the group Bioinformatics on 2007-09-14 19:21:35 as ** along with 1 group structural_bioinformatics
  • Identifying and engineering ion pairs in adenylate kinases. Insights from molecular dynamics simulations of thermophilic and mesophilic homologues
    The Journal Of Biological Chemistry, Vol. 280, No. 35. (2 September 2005), pp. 30943-30948.
    by Euiyoung Bae, George N Phillips
    posted to ion_pairs kinases md_simulation protein_design by barry to the group Bioinformatics on 2005-09-20 18:56:31 as * along with 1 group structural_bioinformatics
  • Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases
    PNAS, Vol. 100, No. 8. (15 April 2003), pp. 4463-4468.
    by Lewyn Li, Eugene I Shakhnovich, Leonid A Mirny
    posted to kinases protein_sequence protein_structure by barry to the group Bioinformatics on 2005-12-13 13:25:02 as ** along with 2 people and 1 group Einat ankur_iitg structural_bioinformatics
  • Formation and characterization of kinesin.ADP.fluorometal complexes.
    J Biochem (Tokyo), Vol. 132, No. 4. (October 2002), pp. 573-579.
    by H Shibuya, K Kondo, N Kimura, S Maruta
    posted to kinases molecular_motors nucleotide_analogues by barry to the group Bioinformatics on 2005-06-24 23:36:09 as ** along with 1 group structural_bioinformatics
  • Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit.
    FEBS Lett, Vol. 579, No. 12. (9 May 2005), pp. 2679-2685.
    by S Pantano, M Zaccolo, P Carloni
    posted to kinases by barry to the group Bioinformatics on 2005-06-24 00:49:19 as ** along with 1 group structural_bioinformatics
  • A comprehensive update of the sequence and structure classification of kinases.
    BMC Struct Biol, Vol. 5, No. 1. (16 March 2005)
    by S Cheek, K Ginalski, H Zhang, NV Grishin
    posted to kinases by barry to the group Bioinformatics on 2005-06-24 00:29:20 as ** along with 1 person and 1 group tjimenez structural_bioinformatics
  • The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication
    Progress in Biophysics and Molecular Biology, Vol. 71, No. 3-4. (April 1999), pp. 313-341.
    by Christopher M Smith, Elzbieta Radzio-Andzelm, Madhusudan, Pearl Akamine, Susan S Taylor
    posted to kinases protein_sequence protein_structure review by barry to the group Bioinformatics on 2005-05-25 03:19:24 as ** along with 1 group structural_bioinformatics
  • Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase.
    Nat Struct Biol, Vol. 9, No. 4. (April 2002), pp. 273-277.
    by Madhusudan, P Akamine, NH Xuong, SS Taylor
    posted to kinases protein_structure by barry to the group Bioinformatics on 2005-05-25 03:07:06 as ** along with 1 group structural_bioinformatics
  • Dynamics of cAMP-dependent protein kinase.
    Chem Rev, Vol. 101, No. 8. (August 2001), pp. 2243-2270.
    by DA Johnson, P Akamine, E Radzio-Andzelm, M Madhusudan, SS Taylor
    posted to kinases protein_dynamics review by barry to the group Bioinformatics on 2005-05-25 00:09:53 as ** along with 1 group structural_bioinformatics
  • PKA: a portrait of protein kinase dynamics
    Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, Vol. 1697, No. 1-2. (11 March 2004), pp. 259-269.
    by S Taylor, J Yang, J Wu, N Haste, E Radzio-Andzelm, G Anand
    posted to kinases protein_design review by barry to the group Bioinformatics on 2005-05-25 00:01:55 as ** along with 1 person and 1 group neils structural_bioinformatics
  • Regulation of Protein Kinases: Controlling Activity through Activation Segment Conformation
    Molecular Cell, Vol. 15, No. 5. (10 September 2004), pp. 661-675.
    by Brad Nolen, Susan Taylor, Gourisankar Ghosh
    posted to kinases protein_dynamics review by barry to the group Bioinformatics on 2005-05-24 23:58:23 as ** along with 1 person and 1 group tjimenez structural_bioinformatics
  • Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism
    Proceedings of the National Academy of Sciences (13 November 2007), 0706443104.
    by Karunesh Arora, Charles L Brooks
    posted to allosteric kinases md_simulation by barry to the group structural_bioinformatics on 2007-11-27 23:23:59 as ** along with 5 people and 1 group allmensch cactus sobolevnrm jlh64 karunesh baker-group
  • Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
    Nature, Vol. 450, No. 7170., pp. 741-744.
    by Xuewu Zhang, Kerry A Pickin, Ron Bose, Natalia Jura, Philip A Cole, John Kuriyan
    posted to rev_ref peptides kinases domain by Evangelia on 2008-05-12 10:59:35 as ***
  • From the Cover: Structural basis and prediction of substrate specificity in protein serine/threonine kinases
    PNAS, Vol. 100, No. 1. (7 January 2003), pp. 74-79.
    by Ross I Brinkworth, Robert A Breinl, Bostjan Kobe
    posted to interaction kinases phospho_peptides specificity by Evangelia on 2008-03-27 16:42:34 as *** along with 1 person ankur_iitg
  • The protein kinase complement of the human genome.
    Science, Vol. 298, No. 5600. (6 December 2002), pp. 1912-1934.
    by G Manning, DB Whyte, R Martinez, T Hunter, S Sudarsanam
    posted to phospho_peptides peptides kinases by Evangelia on 2008-05-10 19:33:28 as *** along with 9 people renatomilani taten daed Yanno ceolas tjimenez kuhn aqeel lenov
  • Protein flexibility in ligand docking and virtual screening to protein kinases.
    J Mol Biol, Vol. 337, No. 1. (12 March 2004), pp. 209-225.
    by CN Cavasotto, RA Abagyan
    posted to docking-flexible flexible-receptor kinases by dgruiz on 2005-01-31 13:13:56 as ** along with 7 people and 3 groups BragilMassoud yongzhao sangeetha anwazo daevans kazemi LamBras Bioinformatics TSRI_MGL insilicodrug
  • Patterns of somatic mutation in human cancer genomes
    Nature, Vol. 446, No. 7132., pp. 153-158.
    by Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O’meara, Imre Vastrik, Esther E Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P Cahill, David N Louis, Peter Goldstraw, Andrew G Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L Weber, Yoke-Eng Chiew, Anna Defazio, Mel F Greaves, Anthony R Green, Peter Campbell, Ewan Birney, Douglas F Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok K Khoo, Bin T Teh, Siu T Yuen, Suet Y Leung, Richard Wooster, Andrew P Futreal, Michael R Stratton
    posted to cancer genome kinases sequencing by daed on 2008-04-14 15:36:09 as ** along with 9 people cerami frohike ramensky Petersarkies kentsis jfr massivemayhem efge Garamonfok
  • Structural interaction fingerprints: a new approach to organizing, mining, analyzing, and designing protein-small molecule complexes.
    Chem Biol Drug Des, Vol. 67, No. 1. (January 2006), pp. 5-12.
    by J Singh, Z Deng, G Narale, C Chuaqui
    posted to docking fingerprints kinases screening by BragilMassoud on 2006-09-15 15:36:13 as **
  • Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors
    Science, Vol. 308, No. 5726. (27 May 2005), pp. 1318-1321.
    by Michael S Cohen, Chao Zhang, Kevan M Shokat, Jack Taunton
    posted to alignment design docking kinases pharmacology protein screening by BragilMassoud on 2005-06-08 17:31:31 as *** along with 2 people RJDReid MaggieYe
  • Strategies to overcome resistance to targeted protein kinase inhibitors.
    Nat Rev Drug Discov, Vol. 3, No. 12. (December 2004), pp. 1001-1010.
    by H Daub, K Specht, A Ullrich
    posted to docking kinases pharmacology screening by BragilMassoud on 2005-06-08 17:27:34 as ***
  • Virtual screening to enrich a compound collection with CDK2 inhibitors using docking, scoring, and composite scoring models.
    Proteins, Vol. 60, No. 4. (1 September 2005), pp. 629-643.
    by S Cotesta, F Giordanetto, JY Trosset, P Crivori, RT Kroemer, PF Stouten, A Vulpetti
    posted to affinity docking energyfunctions kinases screening by BragilMassoud on 2006-07-11 20:30:21 as **
  • Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma
    Cancer Res, Vol. 66, No. 2. (15 January 2006), pp. 632-637.
    by Michael I Koukourakis, Alexandra Giatromanolaki, Adrian L Harris, Efthimios Sivridis
    posted to cancer kinases pdk1 by BragilMassoud on 2007-02-07 13:45:32 as ** along with 1 person samoday
  • Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2
    BMC Bioinformatics, Vol. 8 (07 February 2007), 45.
    by Jenny Gu, Philip E Bourne
    posted to flexible_protein kinases by BragilMassoud on 2007-02-21 13:27:55 as ** along with 2 people lna aqeel
  • A priori inference of cross reactivity for drug-targeted kinases.
    J Med Chem, Vol. 49, No. 11. (1 June 2006), pp. 3092-3100.
    by A Fernandez, S Maddipati
    posted to dehydron kinases by BragilMassoud on 2006-05-27 12:09:39 as ** along with 2 people tjimenez kuhn
  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    Biochem J, Vol. 351, No. Pt 1. (1 October 2000), pp. 95-105.
    by SP Davies, H Reddy, M Caivano, P Cohen
    posted to affinity kinases pharmacology specificity by BragilMassoud on 2006-07-27 21:07:47 as **
  • The specificities of protein kinase inhibitors: an update.
    Biochem J, Vol. 371, No. Pt 1. (1 April 2003), pp. 199-204.
    by J Bain, H McLauchlan, M Elliott, P Cohen
    posted to affinity kinases pharmacology specificity by BragilMassoud on 2006-07-27 21:07:05 as ** along with 1 person jyuh
  • Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
    J Med Chem, Vol. 49, No. 13. (29 June 2006), pp. 3826-3831.
    by H Lu, U Schulze-Gahmen
    posted to docking kinases by BragilMassoud on 2006-06-25 13:01:11 as **
  • Modified AutoDock for accurate docking of protein kinase inhibitors.
    J Comput Aided Mol Des, Vol. 16, No. 2. (February 2002), pp. 113-127.
    by OV Buzko, AC Bishop, KM Shokat
    posted to docking energyfunctions kinases protein screening by BragilMassoud on 2005-06-16 13:51:59 as **
  • Minimizing false positives in kinase virtual screens.
    Proteins (17 May 2006)
    by Emanuele Perola
    posted to docking kinases screening by BragilMassoud on 2006-05-22 20:01:44 as ** along with 1 person schlauchi
  • Multiple targeted tyrosine kinase inhibition in the clinic: all for one or one for all?
    Eur J Cancer, Vol. 42, No. 10. (July 2006), pp. 1351-1356.
    by MJ de Jonge, J Verweij
    posted to kinases pharmacology specificity by BragilMassoud on 2007-05-14 15:04:18 as **
  • Toward a pharmacophore for kinase frequent hitters.
    J Med Chem, Vol. 47, No. 23. (4 November 2004), pp. 5616-5619.
    by AM Aronov, MA Murcko
    posted to kinases pharmacology by BragilMassoud on 2006-02-07 18:05:14 as ** along with 1 person Yanno
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