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タグ: comt [55 articles]

Recent papers classified by the tag comt.
  • Schizotypal dimensions: An intermediate phenotype associated with the COMT high activity allele:
    Am J Med Genet B Neuropsychiatr Genet (10 October 2006)
    by Franck Schürhoff, Andrei Szöke, Fabien Chevalier, Isabelle Roy, Alexandre Méary, Frank Bellivier, Bruno Giros, Marion Leboyer
    posted to comt by yunyan0201 on 2006-12-02 11:06:01 as ***
  • Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow
    Molecular Psychiatry, Vol. aop, No. current. (25 January 2005)
    by B Ho, TH Wassink, DS O'Leary, VC Sheffield, NC Andreasen
    posted to cbf comt frontal gene lobe memory morphology mri polymorphism schizophrenia working by yanhaomouse on 2006-09-20 10:46:39 as ***
  • Ionic influence on human erythrocyte catechol-O-methyltransferase activity
    BIOCHEM. PHARMACOL., Vol. 30, No. 17. (1981), pp. 2481-2482.
    by Y Floderus, J Saaf, SB Ross, L Wetterberg
    posted to comt by softsimu on 2007-12-12 19:25:39 as **
  • Ro 40-7592. Catecholamine-O-methyltransferase (COMT) inhibitor
    DRUGS FUTURE, Vol. 16, No. 8. (1991), pp. 719-721.
    by J Borgulya, M Da Prada, J Dingemanse, R Scherschlicht, B Schlappi, G Zurcher
    posted to comt by softsimu on 2007-12-12 18:31:58 as **
  • Kinetics and crystal structure of catechol-O-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application
    Mol. Pharmacol., Vol. 62, No. 4. (2002), pp. 795-805.
    by MJ Bonifa?cio, M Archer, ML Rodrigues, PM Matias, DA Learmonth, MA Carrondo, P Soares-Da-Silva
    posted to comt by softsimu on 2007-12-12 18:30:39 as **
  • On the Nature of the Transition State in Catechol O-Methyltransferase. A Complementary Study Based on Molecular Dynamics and Potential Energy Surface Explorations
    J. Am. Chem. Soc., Vol. 127, No. 30. (3 August 2005), pp. 10648-10655.
    by M Roca, J Andres, V Moliner, I Tunon, J Bertran
    posted to comt by softsimu on 2008-04-09 16:42:00 as **
  • X-ray crystal structure of a bisubstrate inhibitor bound to the enzyme catechol-O-methyltransferase: A dramatic effect of inhibitor preorganization on binding affinity
    Angew. Chem. Int. Ed., Vol. 40, No. 21. (2001), pp. 4040-4042.
    by C Lerner, A Ruf, V Gramlich, B Masjost, G Zu?rcher, R Jakob-Roetne, E Borroni, F Diederich
    posted to comt nopdf by softsimu on 2007-12-12 18:48:06 as **
  • Catechol-O-methyltransferase genotype and dopamine regulation in the human brain
    J. Neurosci., Vol. 23, No. 6. (2003), pp. 2008-2013.
    by M Akil, BS Kolachana, DA Rothmond, TM Hyde, DR Weinberger, JE Kleinman
    posted to comt by softsimu on 2007-12-12 18:28:08 as **
  • Pharmacokinetic-Pharmacodynamic Interaction between BIA 3-202, a Novel COMT Inhibitor, and Levodopa/Carbidopa
    Clin. Neuropharmacol., Vol. 27, No. 1. (2004), pp. 17-24.
    by L Almeida, M Vaz-Da-Silva, P Silveira, A Falca?o, J Maia, A Loureiro, L Torra?o, R Machado, L Wright, P Soares-Da-Silva
    posted to comt nopdf by softsimu on 2007-12-12 18:11:55 as **
  • Pharmacokinetic and Pharmacodynamic Profiles of BIA 3-202, a Novel Catechol-O-Methyltransferase (COMT) Inhibitor, during Multiple-Dose Administration to Healthy Subjects
    J. Clin. Pharmacol., Vol. 43, No. 12. (2003), pp. 1350-1360.
    by L Almeida, P Soares-Da-Silva
    posted to comt by softsimu on 2007-12-12 18:11:28 as **
  • Medicinal chemistry in academia: Molecular recognition with biological receptors
    Chem. Commun., Vol. 10, No. 5. (2004), pp. 477-480.
    by F Hof, F Diederich
    posted to comt receptors by softsimu on 2007-12-12 18:45:34 as **
  • Catechol-O-methyltransferase and its inhibitors in Parkinson's disease
    CNS Drug Rev., Vol. 13, No. 3. (2007), pp. 352-379.
    by MJ Bonifa?cio, PN Palma, L Almeida, P Soares-Da-Silva
    posted to comt by softsimu on 2007-12-12 18:10:07 as **
  • In vitro effect of haloperidol, chlorpromazine, imipramine and lithium on the erythrocyte catechol-O-methyltransferase
    ARZNEIM.-FORSCH. DRUG RES., Vol. 32, No. 6. (1982), pp. 681-683.
    by JJ Hoo, P Noldt, WJ Beckermann
    posted to comt by softsimu on 2007-12-12 19:01:21 as **
  • Inhibition of catechol-o-methyltransferase by 1-vinyl derivatives of nitrocatechols and nitroguaiacols. Kinetics of the irreversible inhibition by 3-(3-hydroxy-4-methoxy-5-nitro benzylidene)-2,4-pentanedione
    BIOCHEM. PHARMACOL., Vol. 45, No. 10. (1993), pp. 1973-1981.
    by RA Perez, E Fernandez-Alvarez, O Nieto, FJ Piedrafita
    posted to comt by softsimu on 2007-12-12 19:00:41 as **
  • Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): Efficient inhibition despite the lack of a nitro group
    ChemBioChem, Vol. 5, No. 9. (2004), pp. 1270-1274.
    by R Paulini, C Lerner, R Jakob-Roetne, G Zu?rcher, E Borroni, F Diederich
    posted to comt by softsimu on 2007-12-12 18:44:30 as **
  • The catechol-O-methyltransferase polymorphism: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes
    Neuropsychopharmacology, Vol. 29, No. 11. (2004), pp. 1943-1961.
    by RM Bilder, J Volavka, HM Lachman, AA Grace
    posted to comt by softsimu on 2007-12-12 18:30:05 as **
  • Human catechol-O-methyltransferase: Cloning and expression of the membrane-associated form
    PROC. NATL. ACAD. SCI. U. S. A., Vol. 88, No. 4. (1991), pp. 1416-1420.
    by B Bertocci, V Miggiano, M Da Prada, Z Dembic, HW Lahm, P Malherbe
    posted to comt by softsimu on 2007-12-12 18:14:43 as **
  • The discovery of dopamine deficiency in the parkinsonian brain
    J. Neural Transm. Suppl., No. 70. (2006), pp. 9-15.
    by O Hornykiewicz
    posted to comt by softsimu on 2007-12-12 18:33:27 as **
  • Interactions with Aromatic Rings in Chemical and Biological Recognition
    Angewandte Chemie International Edition, Vol. 42, No. 11. (13 March 2003), pp. 1210-1250.
    by Emmanuel A Meyer, Dipl, Ronald K Castellano, Dr, François Diederich, Dr
    posted to comt ligands receptors by softsimu on 2007-12-12 18:46:24 as ** along with 1 person diquesto
  • Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase
    Journal of Medicinal Chemistry, Vol. 24, No. 11. (1981), pp. 1271-1277.
    by GL Anderson, DL Bussolotti, JK Coward
    posted to comt by softsimu on 2007-12-12 18:12:32 as **
  • New, selective catechol-O-methyltransferase inhibitors as therapeutic agents in Parkinson's disease
    Pharmacol. Ther., Vol. 81, No. 1. (1999), pp. 1-36.
    by V Bonifati, G Meco
    posted to comt by softsimu on 2007-12-12 18:31:21 as **
  • Comparison of the Dynamics for Ground-State and Transition-State Structures in the Active Site of Catechol O-Methyltransferase
    J. Am. Chem. Soc., Vol. 122, No. 30. (2 August 2000), pp. 7165-7171.
    by EY Lau, TC Bruice
    posted to comt by softsimu on 2008-02-12 23:38:25 as **
  • Transition-State and Ground-State Structures and Their Interaction with the Active-Site Residues in Catechol O-Methyltransferase
    J. Am. Chem. Soc., Vol. 122, No. 1. (12 January 2000), pp. 46-51.
    by K Kahn, TC Bruice
    posted to comt by softsimu on 2008-02-12 23:38:45 as **
  • Molecular mechanisms of schizophrenia
    Cell. Physiol. Biochem., Vol. 20, No. 6. (2007), pp. 687-702.
    by UE Lang, I Puls, DJ Mu?ller, N Strutz-Seebohm, J Gallinat
    posted to comt by softsimu on 2007-12-12 18:07:13 as **
  • A new class of inhibitors for the metalloprotease neprilysin based on a central imidazole scaffold
    Helv. Chim. Acta, Vol. 88, No. 4. (2005), pp. 707-730.
    by S Sahli, B Stump, T Welti, WB Schweizer, F Diederich, D Blum-Kaelin, JD Aebi, HJ Bo?hm
    posted to comt by softsimu on 2007-12-12 18:44:08 as **
  • Molecular recognition with biological receptors: Structure-based design of thrombin inhibitors
    Chimia, Vol. 54, No. 11. (2000), pp. 633-639.
    by P Betschmann, C Lerner, S Sahli, U Obst, F Diederich
    posted to comt inhibitors receptors by softsimu on 2007-12-12 18:49:12 as **
  • Treatment of cognitive deficits associated with schizophrenia: Potential role of catechol-O-methyltransferase inhibitors
    CNS Drugs, Vol. 21, No. 7. (2007), pp. 535-557.
    by JA Apud, DR Weinberger
    posted to comt by softsimu on 2007-12-12 18:27:24 as **
  • Catechol o methyl transferase in mouse liver plasma membranes
    BIOCHEM. BIOPHYS. RES. COMMUN., Vol. 64, No. 4. (1975), pp. 1293-1302.
    by JR Aprille, DF Malamud
    posted to comt by softsimu on 2007-12-12 18:29:16 as **
  • Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans
    Drugs R D, Vol. 4, No. 4. (2003), pp. 207-217.
    by L Almeida, P Soares-Da-Silva
    posted to comt by softsimu on 2007-12-12 18:11:06 as **
  • Calcium-sensitive accumulation of norepinephrine in rat cerebral cortex
    EUR. J. PHARMACOL., Vol. 69, No. 3. (1981), pp. 301-312.
    by GH Burrows, MM Myers, SR Whittemore, ED Hendley
    posted to comt no-tag by softsimu on 2007-12-12 17:59:23 as ** along with 1 person pawelp
  • Importance of Correlated Motions in Forming Highly Reactive Near Attack Conformations in Catechol O-Methyltransferase
    J. Am. Chem. Soc., Vol. 120, No. 48. (9 December 1998), pp. 12387-12394.
    by EY Lau, TC Bruice
    posted to comt by softsimu on 2008-02-12 23:39:03 as **
  • Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): Influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity
    Org. Biomol. Chem., Vol. 1, No. 1. (2003), pp. 42-49.
    by C Lerner, B Masjost, A Ruf, V Gramlich, R Jakob-Roetne, G Zu?rcher, E Borroni, F Diederich
    posted to comt by softsimu on 2007-12-12 18:47:23 as **
  • Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT)
    Chem Eur J, Vol. 6, No. 6. (2000), pp. 971-982.
    by B Masjost, P Ballmer, E Borroni, G Zu?rcher, FK Winkler, R Jakob-Roetne, F Diederich
    posted to comt by softsimu on 2007-12-12 18:37:21 as **
  • Implicit versus explicit solvent in free energy calculations of enzyme catalysis: Methyl transfer catalyzed by catechol O-methyltransferase
    The Journal of Chemical Physics, Vol. 124, No. 17. (2006)
    by Thomas H Rod, Patrik Rydberg, Ulf Ryde
    posted to comt by softsimu on 2008-04-09 16:34:54 as **
  • QM-FE and Molecular Dynamics Calculations on Catechol O-Methyltransferase: Free Energy of Activation in the Enzyme and in Aqueous Solution and Regioselectivity of the Enzyme-Catalyzed Reaction
    J. Am. Chem. Soc., Vol. 122, No. 11. (22 March 2000), pp. 2586-2596.
    by B Kuhn, PA Kollman
    posted to comt by softsimu on 2008-02-17 00:02:56 as **
  • Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain Catechol-O-methyltransferase
    J. PHARMACOL. EXP. THER., Vol. 282, No. 2. (1997), pp. 812-817.
    by N Borges, MA Vieira-Coelho, A Parada, P Soares-Da-Silva
    posted to comt by softsimu on 2007-12-12 18:25:57 as **
  • Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex
    Acta Crystallographica Section F: Structural Biology and Crystallization Communications, Vol. 61, No. 1. (01 January 2005), pp. 118-120.
    by Rodrigues, , Bonifácio, , Soares-Da-Silva, , Carrondo, , Archer,
    posted to comt by softsimu on 2007-12-12 18:39:27 as **
  • Metabolism of L-dopa after inhibition of catechol-O-methyl transferase.
    Eur J Pharmacol, Vol. 17, No. 1. (1972), pp. 163-166.
    by RJ Baldessarini, KV Chace
    posted to comt by softsimu on 2007-12-12 18:13:42 as **
  • Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: Structure-activity relationship and molecular-modeling studies
    Biochemical Pharmacology, Vol. 69, No. 10. (15 May 2005), pp. 1523-1531.
    by Dapeng Chen, Ching Y Wang, Joshua D Lambert, Ni Ai, William J Welsh, Chung S Yang
    posted to comt by softsimu on 2008-06-30 20:54:25 as **
  • Calcium Ion Coordination: A Comparison with That of Beryllium, Magnesium, and Zinc
    J. Am. Chem. Soc., Vol. 118, No. 24. (19 June 1996), pp. 5752-5763.
    by AK Katz, JP Glusker, SA Beebe, CW Bock
    posted to berykkium calcium comt ions magnesium zinc by softsimu on 2007-12-13 16:16:27 as **
  • Molecular dynamics simulations of the enzyme Catechol-O-Methyltransferase: methodological issues
    SAR and QSAR in Environmental Research, Vol. 19, No. 1. (2008), pp. 179-189.
    by A Bunker, PT Männistö, St. Pierre, T Róg, P Pomorski, L Stimson, M Karttunen
    posted to comt by softsimu on 2008-03-05 21:01:38 as ** along with 1 person Terkko
  • Kinetic reaction mechanism for magnesium binding to membrane-bound and soluble catechol O-methyltransferase
    Biochemistry, Vol. 26, No. 10. (1987), pp. 2955-2958.
    by DR Jeffery, JA Roth
    posted to comt by softsimu on 2007-12-12 18:34:42 as ** along with 1 person pawelp
  • Bisubstrate inhibitors of catechol O-methyltransferase (COMT): The crucial role of the ribose structural unit for inhibitor binding affinity
    ChemMedChem, Vol. 1, No. 3. (2006), pp. 340-357.
    by R Paulini, C Trindler, C Lerner, L Bra?ndli, WB Schweizer, R Jakob-Roetne, G Zu?rcher, E Borroni, F Diederich
    posted to comt by softsimu on 2007-12-12 18:38:44 as **
  • Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors
    Journal of Medicinal Chemistry, Vol. 32, No. 4. (1989), pp. 841-846.
    by R Ba?ckstro?m, E Honkanen, A Pippuri, P Kairisalo, J Pystynen, K Heinola, E Nissinen, IB Linden, PT Ma?nnisto?, S Kaakkola, P Pohto
    posted to comt by softsimu on 2007-12-12 18:13:14 as **
  • QM/MM Determination of Kinetic Isotope Effects for COMT-Catalyzed Methyl Transfer Does Not Support Compression Hypothesis
    J. Am. Chem. Soc., Vol. 126, No. 28. (21 July 2004), pp. 8634-8635.
    by GD Ruggiero, IH Williams, M Roca, V Moliner, I Tunon
    posted to comt qm-mm by softsimu on 2008-04-09 16:36:36 as **
  • An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD
    American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 147B, No. 3. (March 2008), pp. 397-402.
    by AM Boonstra, JJS Kooij, JK Buitelaar, J Oosterlaan, JA Sergeant, Heister, B Franke
    posted to adhd adult comt dat drd4 genotype neurocognitive-testing neuropsychology by shupsy on 2008-03-30 23:58:15 as **
  • Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism.
    Movement disorders : official journal of the Movement Disorder Society, Vol. 19, No. 8. (August 2004), pp. 885-891.
    by T Foltynie, TE Goldberg, SG Lewis, AD Blackwell, BS Kolachana, DR Weinberger, TW Robbins, RA Barker
    posted to snp pd comt by psique on 2008-04-29 17:13:12 as * along with 1 group parkinson's disease references
  • The met158 allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case–control study and meta-analysis
    Molecular Psychiatry, Vol. aop, No. current.
    by EC Pooley, N Fineberg, PJ Harrison,
    posted to snp comt ocd by psique on 2007-12-01 15:34:16 as read along with 1 person and 1 group kochhan psique personal
  • Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: A hypothesis.
    Med Hypotheses (27 April 2007)
    by Kenneth Blum, Thomas J H J Chen, Brian Meshkin, Roger L L Waite, B William Downs, Seth H H Blum, Julie F F Mengucci, Vanessa Arcuri, Eric R R Braverman, Tomas Palomo
    posted to comt dopamine genotype reward by oamg on 2007-05-28 18:32:35 as ** along with 1 group Glimcher_Lab
  • Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning
    Proceedings of the National Academy of Sciences, Vol. 104, No. 41. (9 October 2007), pp. 16311-16316.
    by Michael J Frank, Ahmed A Moustafa, Heather M Haughey, Tim Curran, Kent E Hutchison
    posted to comt by MWagner on 2007-11-02 16:47:43 as ** along with 2 people and 1 group brian nelmor 801
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