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タグ: activation [420 articles]

Recent papers classified by the tag activation.
  • notes Variability and robustness in T cell activation from regulated heterogeneity in protein levels.
    Science (New York, N.Y.), Vol. 321, No. 5892. (22 August 2008), pp. 1081-1084.
    by O Feinerman, J Veiga, JR Dorfman, RN Germain, G Altan-Bonnet
    posted to variety thesis t-cells signalling protein heterogeneity confounder activation by Zephyrus on 2008-09-27 18:46:23 as ** along with 1 person oelemento
  • Mediator and the mechanism of transcriptional activation.
    Trends Biochem Sci, Vol. 30, No. 5. (May 2005), pp. 235-239.
    by RD Kornberg
    posted to transcription review repressor mediator kornberg enhancer activator activation by xico on 2007-01-14 20:39:46 as ** along with 2 people and 1 group gloria hplatero WetBiology
  • Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.
    J Biol Chem, Vol. 278, No. 3. (17 January 2003), pp. 1892-1903.
    by C Govaerts, A Bondue, JY Springael, M Olivella, X Deupi, E Le Poul, SJ Wodak, M Parmentier, L Pardo, C Blanpain
    posted to activation ccr5 helix tm2 tm3 by xdeupi on 2005-10-25 03:15:57 as read along with 1 person and 1 group tkershaw LabCompMed
  • Primary photoprocess in vision: minimal motion to reach the photo- and bathorhodopsin intermediates.
    J Phys Chem B, Vol. 109, No. 18. (12 May 2005), pp. 9104-9110.
    by F Blomgren, S Larsson
    posted to activation retinal rhodopsin theory by xdeupi on 2007-07-30 16:59:24 as ** along with 1 group LabCompMed
  • Determining the Potency and Molecular Mechanism of Action of Insurmountable Antagonists.
    J Pharmacol Exp Ther (20 July 2006)
    by Terry P P Kenakin, Stephen Jenkinson, Christian Watson
    posted to activation drug ligands agonist pharmacology by xdeupi on 2006-09-05 09:51:58 as **** along with 1 group LabCompMed
  • NMR analysis of rhodopsin-transducin interactions.
    Vision Res, Vol. 46, No. 27. (December 2006), pp. 4482-4492.
    by KD Ridge, JP Marino, T Ngo, E Ramon, DM Brabazon, NG Abdulaev
    posted to activation gproteins nmr rhodopsin by xdeupi on 2007-02-20 09:54:49 as ** along with 1 group LabCompMed
  • Linkage between the intramembrane H-bond network around aspartic acid 83 and the cytosolic environment of helix 8 in photoactivated rhodopsin.
    J Mol Biol, Vol. 366, No. 4. (2 March 2007), pp. 1129-1141.
    by N Lehmann, U Alexiev, K Fahmy
    posted to activation d250 fluorescence npxxy rhodopsin by xdeupi on 2007-06-05 15:58:33 as ***** along with 1 group LabCompMed
  • The first extracellular loop of the Saccharomyces cerevisiae GPCR STE2P undergoes a conformational change upon ligand binding.
    J Biol Chem (9 February 2007)
    by Melinda Hauser, Sarah Kauffman, Byung-Kwon K Lee, Fred Naider, Jeffrey M M Becker
    posted to activation binding gpcr loops by xdeupi on 2007-02-20 10:09:06 as ** along with 1 group LabCompMed
  • An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.
    J Biol Chem, Vol. 280, No. 17. (29 April 2005), pp. 17135-17141.
    by E Urizar, S Claeysen, X Deupí, C Govaerts, S Costagliola, G Vassart, L Pardo
    posted to activation n745 n749 switch thyrotropin by xdeupi on 2005-10-25 03:13:29 as read along with 1 group LabCompMed
  • PDZ-domain arrays for identifying components of GPCR signaling complexes.
    Trends Pharmacol Sci (8 August 2006)
    by Peter Day, Brian Kobilka
    posted to activation gpcr by xdeupi on 2006-09-05 10:59:12 as ** along with 1 group LabCompMed
  • The physiological significance of constitutive receptor activity.
    Trends Pharmacol Sci (28 October 2005)
    by Terry Kenakin
    posted to activation cam gpcr by xdeupi on 2005-11-04 21:59:07 as **** along with 1 group LabCompMed
  • Modeling activated states of GPCRs: the rhodopsin template.
    J Comput Aided Mol Des, Vol. 20, No. 7-8. (g 2006), pp. 437-448.
    by MY Niv, L Skrabanek, M Filizola, H Weinstein
    posted to activation dynamics md rhodopsin by xdeupi on 2007-03-26 10:22:13 as **** along with 1 person and 1 group IrinaMoreira LabCompMed
  • Functional domains of the mouse beta3-adrenoceptor associated with differential G protein coupling.
    J Pharmacol Exp Ther, Vol. 315, No. 3. (December 2005), pp. 1354-1361.
    by M Sato, DS Hutchinson, T Bengtsson, A Floren, U Langel, T Horinouchi, BA Evans, RJ Summers
    posted to activation b2ar gproteins by xdeupi on 2006-01-30 09:22:20 as ** along with 1 group LabCompMed
  • Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent.
    Proc Natl Acad Sci U S A, Vol. 98, No. 9. (24 April 2001), pp. 4877-4882.
    by K Cai, Y Itoh, HG Khorana
    posted to activation active-state gproteins icl3 rhodopsin by xdeupi on 2008-03-12 15:47:55 as **
  • Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.
    J Biol Chem, Vol. 279, No. 53. (31 December 2004), pp. 55886-55894.
    by JM Janz, DL Farrens
    posted to activation binding rhodopsin by xdeupi on 2006-05-29 11:58:42 as **** along with 1 group LabCompMed
  • Proton movement and photointermediate kinetics in rhodopsin mutants.
    Biochemistry, Vol. 45, No. 17. (2 May 2006), pp. 5430-5439.
    by JW Lewis, I Szundi, MA Kazmi, TP Sakmar, DS Kliger
    posted to activation protonation rhodopsin by xdeupi on 2007-07-30 17:00:28 as ** along with 1 group LabCompMed
  • G protein coupled receptor structure and activation.
    Biochim Biophys Acta, Vol. 1768, No. 4. (April 2007), pp. 794-807.
    by BK Kobilka
    posted to switch review lmc_101 gpcr b2ar activation by xdeupi on 2007-06-02 19:19:32 as ** along with 4 people and 2 groups jyuh Fritz merj adamsdi neurolit LabCompMed
  • Agonist binding: a multistep process.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1060-1062.
    by B Kobilka
    posted to activation agonist b2ar binding gpcr by xdeupi on 2005-11-02 22:50:37 as ** along with 1 group LabCompMed
  • Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation.
    J Biol Chem, Vol. 281, No. 26. (30 June 2006), pp. 18120-18125.
    by B Behr, C Hoffmann, G Ottolina, KN Klotz
    posted to activation agonist b2ar binding drug ligands modeling mutation pharmacology structure by xdeupi on 2006-09-05 11:05:20 as *** along with 1 group LabCompMed
  • Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states.
    Mol Pharmacol, Vol. 57, No. 1. (January 2000), pp. 198-210.
    by C Ambrosio, P Molinari, S Cotecchia, T Costa
    posted to activation agonist b2ar ser tm5 by xdeupi on 2005-10-31 23:56:50 as read along with 1 group LabCompMed
  • Coupling ligand structure to specific conformational switches in the [beta]2-adrenoceptor
    Nat Chem Biol, Vol. 2, No. 8. (2006), pp. 417-422.
    by Xiaojie Yao, Charles Parnot, Xavier Deupi, Venkata R Ratnala, Gayathri Swaminath, David Farrens, Brian Kobilka
    posted to activation b2ar bimane lock by xdeupi on 2006-09-07 14:39:58 as ** along with 1 person and 1 group lechristophe LabCompMed
  • Single-molecule spectroscopy of the beta(2) adrenergic receptor: observation of conformational substates in a membrane protein.
    Proc Natl Acad Sci U S A, Vol. 98, No. 15. (17 July 2001), pp. 8469-8474.
    by G Peleg, P Ghanouni, BK Kobilka, RN Zare
    posted to activation agonist b2ar by xdeupi on 2005-12-16 10:21:35 as read along with 1 person and 2 groups yanjiang LabCompMed moernerlab
  • Local peptide movement in the photoreaction intermediate of rhodopsin.
    Proc Natl Acad Sci U S A, Vol. 103, No. 34. (22 August 2006), pp. 12729-12734.
    by H Nakamichi, T Okada
    posted to activation crystallography retinal rhodopsin structure by xdeupi on 2006-10-26 11:39:03 as ** along with 1 group LabCompMed
  • The role of proline residues in the dynamics of transmembrane helices: the case of bacteriorhodopsin
    Molecular Membrane Biology, Vol. 23, No. 2. (8211), pp. 127-135.
    by Peralvarez-Marin, Alex, Bourdelande, Jose-Luis, Querol, Enric, Padros, Esteve
    posted to pro-kink structure activation crystallography helix mutation by xdeupi on 2006-09-05 09:47:32 as ** along with 1 group LabCompMed
  • Genetic analysis of the first and third extracellular loops of the C5a receptor reveals an essential WxFG motif in the first loop.
    J Biol Chem (27 February 2006)
    by Jeffery M M Klco, Gregory V V Nikiforovich, Thomas J J Baranski
    posted to activation gpcr loops by xdeupi on 2006-03-06 10:13:22 as ** along with 1 group LabCompMed
  • Asymmetric conformational changes in a GPCR dimer controlled by G-proteins
    The EMBO Journal, Vol. aop, No. current. (30 November 2006)
    by Marjorie Damian, Aimee Martin, Danielle Mesnier, Jean-Philippe Pin, Jean-Louis Baneres
    posted to activation dimer gproteins by xdeupi on 2007-02-13 14:49:58 as ** along with 1 group LabCompMed
  • A GPCR that is not "DRY".
    Mol Pharmacol, Vol. 68, No. 1. (July 2005), pp. 1-3.
    by CA Flanagan
    posted to activation dry gpcr ionic switch tm3 by xdeupi on 2006-05-23 12:08:02 as **** along with 1 group LabCompMed
  • Dynamic helix interactions in transmembrane signaling.
    Cell, Vol. 127, No. 3. (3 November 2006), pp. 447-450.
    by EE Matthews, M Zoonens, DM Engelman
    posted to activation dynamics helix review transmembrane by xdeupi on 2006-11-14 16:44:32 as ***** along with 2 people and 1 group gcaltabiano ndoelker LabCompMed
  • Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor.
    J Biol Chem, Vol. 276, No. 27. (6 July 2001), pp. 24433-24436.
    by P Ghanouni, Z Gryczynski, JJ Steenhuis, TW Lee, DL Farrens, JR Lakowicz, BK Kobilka
    posted to activation agonist b2ar by xdeupi on 2005-12-16 10:23:33 as read along with 1 group LabCompMed
  • Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV and -VI.
    Mol Pharmacol (14 December 2006)
    by Mette M M Rosenkilde, Michael B B Andersen, Rie Nygaard, Thomas M M Frimurer, Thue W W Schwartz
    posted to ligands ionic chemokine cation-pi agonist activation by xdeupi on 2007-01-11 16:06:35 as ** along with 1 group LabCompMed
  • Crystallographic analysis of primary visual photochemistry.
    Angew Chem Int Ed Engl, Vol. 45, No. 26. (26 June 2006), pp. 4270-4273.
    by H Nakamichi, T Okada
    posted to activation crystallography rhodopsin structure by xdeupi on 2006-10-26 11:36:51 as ** along with 1 group LabCompMed
  • Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus.
    J Biol Chem, Vol. 279, No. 28. (9 July 2004), pp. 29767-29773.
    by JM Janz, DL Farrens
    posted to activation bimane fluorescence rhodopsin tm6 by xdeupi on 2007-04-04 18:32:56 as ** along with 1 group LabCompMed
  • Orientation of aromatic residues in rhodopsin. Rotation of one tryptophan upon the meta I to meta II transition afer illumination.
    Photochem Photobiol, Vol. 30, No. 2. (August 1979), pp. 295-299.
    by M Chabre, J Breton
    posted to activation fluorescence rhodopsin switch thyrotropin tm6 toggle w648 by xdeupi on 2006-06-02 12:27:52 as ** along with 1 group LabCompMed
  • Asymmetric stability among the transmembrane helices of lactose permease.
    Biochemistry, Vol. 45, No. 26. (4 July 2006), pp. 8088-8095.
    by M Bennett, R D'Rozario, MS Sansom, PL Yeagle
    posted to activation dynamics helix md modeling structure transmembrane by xdeupi on 2006-09-05 11:09:02 as ** along with 1 group LabCompMed
  • notes The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.
    J Biol Chem, Vol. 275, No. 48. (1 December 2000), pp. 37779-37788.
    by G Liapakis, JA Ballesteros, S Papachristou, WC Chan, X Chen, JA Javitch
    posted to activation agonist b2ar binding s542 ser tm5 by xdeupi on 2005-11-01 01:02:07 as ** along with 1 group LabCompMed
  • Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states.
    J Biol Chem, Vol. 279, No. 1. (2 January 2004), pp. 686-691.
    by G Swaminath, Y Xiang, TW Lee, J Steenhuis, C Parnot, BK Kobilka
    posted to activation agonist b2ar binding ligands tm6 by xdeupi on 2005-12-16 10:19:18 as read along with 1 person and 1 group jddowney LabCompMed
  • The ring of the rhodopsin chromophore in a hydrophobic activation switch within the binding pocket.
    J Mol Biol, Vol. 343, No. 3. (22 October 2004), pp. 719-730.
    by PJ Spooner, JM Sharples, SC Goodall, PH Bovee-Geurts, MA Verhoeven, J Lugtenburg, AM Pistorius, WJ Degrip, A Watts
    posted to activation nmr rhodopsin switch w648 by xdeupi on 2006-10-26 11:46:48 as **** along with 1 group LabCompMed
  • Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism.
    J Biomol Screen, Vol. 12, No. 1. (February 2007), pp. 41-49.
    by L Elster, C Elling, A Heding
    posted to activation agonist b2ar fret ligands by xdeupi on 2007-04-10 18:50:15 as ** along with 1 group LabCompMed
  • A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.
    Proc Natl Acad Sci U S A (23 April 2007)
    by Matthew R R Whorton, Michael P P Bokoch, Søren G F G Rasmussen, Bo Huang, Richard N N Zare, Brian Kobilka, Roger K K Sunahara
    posted to activation b2ar dimer by xdeupi on 2007-05-02 09:04:56 as ** along with 1 group LabCompMed
  • A methyl group at C7 of 11-cis-retinal allows chromophore formation but affects rhodopsin activation.
    Vision Res (5 October 2006)
    by Laia Bosch, Arnau Cordomí, Marta Domínguez, Darwin Toledo, Margarita Morillo, Juan J J Pérez, Rosana Alvarez, Angel R R de Lera, Pere Garriga
    posted to activation dynamics md rhodopsin by xdeupi on 2007-02-20 09:56:24 as ** along with 1 person and 1 group arnaucordomi LabCompMed
  • Constitutive activity and inverse agonism at the alpha1adrenoceptors.
    Biochem Pharmacol, Vol. 73, No. 8. (15 April 2007), pp. 1076-1083.
    by S Cotecchia
    posted to activation gpcr review by xdeupi on 2007-06-02 19:31:15 as ** along with 1 group LabCompMed
  • Partial Agonism in a G Protein-coupled Receptor: ROLE OF THE RETINAL RING STRUCTURE IN RHODOPSIN ACTIVATION
    J. Biol. Chem., Vol. 280, No. 40. (7 October 2005), pp. 34259-34267.
    by Franz J Bartl, Olaf Fritze, Eglof Ritter, Rolf Herrmann, Vladimir Kuksa, Krzysztof Palczewski, Klaus P Hofmann, Oliver P Ernst
    posted to activation agonist rhodopsin by xdeupi on 2005-11-22 19:52:14 as *** along with 1 group LabCompMed
  • notes Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.
    J Biol Chem, Vol. 274, No. 31. (30 July 1999), pp. 21867-21872.
    by A Marjamäki, H Frang, M Pihlavisto, AM Hoffrén, T Salminen, MS Johnson, J Kallio, JA Javitch, M Scheinin
    posted to activation binding cys_scanning drug ligands tm5 by xdeupi on 2008-03-07 15:14:37 as ** along with 1 group LabCompMed
  • Toward the active conformations of rhodopsin and the beta2-adrenergic receptor.
    Proteins, Vol. 56, No. 1. (1 July 2004), pp. 67-84.
    by PR Gouldson, NJ Kidley, RP Bywater, G Psaroudakis, HD Brooks, C Diaz, D Shire, CA Reynolds
    posted to activation b2ar modeling rhodopsin structure by xdeupi on 2006-03-08 14:57:08 as ** along with 1 group LabCompMed
  • Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.
    Mol Pharmacol, Vol. 65, No. 5. (May 2004), pp. 1181-1190.
    by G Liapakis, WC Chan, M Papadokostaki, JA Javitch
    posted to activation agonist b2ar by xdeupi on 2005-11-01 00:57:14 as read along with 1 group LabCompMed
  • Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.
    Trends Pharmacol Sci (28 October 2005)
    by Tommaso Costa, Susanna Cotecchia
    posted to activation cam gpcr by xdeupi on 2005-11-04 22:00:17 as **** along with 1 group LabCompMed
  • Chromophore Channeling in the G-Protein Coupled Receptor Rhodopsin.
    J Am Chem Soc (15 May 2007)
    by Ting Wang, Yong Duan
    posted to activation agonist amber binding ligands md modeling rhodopsin by xdeupi on 2007-05-21 10:04:04 as ***** along with 1 group LabCompMed
  • Visual rhodopsin sees the light: Structure and mechanism of G protein signaling.
    J Biol Chem (8 February 2007)
    by Kevin D D Ridge, Krzysztof Palczewski
    posted to activation crystallography review rhodopsin by xdeupi on 2007-02-20 10:11:15 as ** along with 1 group LabCompMed
  • A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
    The EMBO Journal, Vol. aop, No. current. (14 September 2006)
    by Silke Wiesner, Leanne E Wybenga-Groot, Neil Warner, Hong Lin, Tony Pawson, Julie D Forman-Kay, Frank Sicheri
    posted to activation crystallography dynamics mutation nmr switch by xdeupi on 2006-11-17 20:55:01 as ** along with 1 group LabCompMed
  • Multiple signaling states of G-protein-coupled receptors.
    Pharmacol Rev, Vol. 57, No. 2. (June 2005), pp. 147-161.
    by DM Perez, SS Karnik
    posted to activation agonist gpcr pharmacology review rhodopsin switch by xdeupi on 2007-04-26 14:57:25 as ***** along with 1 group LabCompMed
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