Thu, 21 Aug 2008 15:31:54 BST CiteULike: neils Gu http://www.citeulike.org/user/neils/author/Gu CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/neils/article/2054426 <i>Biochem Biophys Res Commun, Vol. 347, No. 4. (Sep 2006), pp. 867-871.</i><br /><br />Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA. BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. Zekun Guo Wenwen Tang Jian Yuan Xinya Chen Bo Wan Xiuting Gu Kuntian Luo Yingli Wang Long Yu Biochem Biophys Res Commun, Vol. 347, No. 4. (Sep 2006), pp. 867-871. 2007-12-04T03:22:09-00:00 2006 Biochem Biophys Res Commun 347 4 867 871 activation alignment amino-acid amp-dependent article-predikin cyclic data enzyme kinase molecular phosphorylation protein protein-serine-threonine sequence threonine