Thu, 21 Aug 2008 17:21:59 BST CiteULike: maralena Weinberg http://www.citeulike.org/user/maralena/author/Weinberg CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/maralena/article/3090170 <i>Trends in genetics : TIG (30 July 2008)</i><br /><br />It has become evident that cancer pathogenesis involves, among other macromolecules, a class of small regulatory RNAs named microRNAs, and that microRNA expression profiles are associated with prognosis and therapeutic outcome in several human cancers. Although the oncogenic or tumor-suppressing functions of several microRNAs have been characterized, the mechanistic roles played by microRNAs specifically in mediating metastasis have been addressed only recently. In this review, we focus on our emerging understanding of the contributions of microRNAs to malignant progression, specifically their functions in mediating tumor invasion and metastasis. These findings illuminate the molecular basis of metastasis and begin to connect small-RNA discoveries to the development of novel clinical biomarkers and therapeutic targets in neoplastic diseases. Micromanagers of malignancy: role of microRNAs in regulating metastasis. Li Ma Robert A Weinberg doi:10.1016/j.tig.2008.06.004 Trends in genetics : TIG (30 July 2008) 2008-08-06T07:32:04-00:00 2008 Trends in genetics : TIG 0168-9525 cancer metastasis microrna http://www.citeulike.org/user/maralena/article/1720168 <i>Nature (26 September 2007)</i> Tumour invasion and metastasis initiated by microRNA-10b in breast cancer Li Ma Julie Teruya-Feldstein Robert Weinberg doi:10.1038/nature06174 Nature (26 September 2007) 2007-10-02T16:57:02-00:00 2007 Nature 0028-0836 Nature Publishing Group microrna mir-10b tumor twist