Thu, 21 Aug 2008 15:25:06 BST CiteULike: lzhonsailing Howlett http://www.citeulike.org/user/lzhonsailing/author/Howlett CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/lzhonsailing/article/1229567 <i>Neuron, Vol. 52, No. 6. (21 December 2006), pp. 997-1009.</i><br /><br />Local control of mRNA translation modulates neuronal development, synaptic plasticity, and memory formation. A poorly understood aspect of this control is the role and composition of ribonucleoprotein (RNP) particles that mediate transport and translation of neuronal RNAs. Here, we show that staufen- and FMRP-containing RNPs in Drosophila neurons contain proteins also present in somatic "P bodies," including the RNA-degradative enzymes Dcp1p and Xrn1p/Pacman and crucial components of miRNA (argonaute), NMD (Upf1p), and general translational repression (Dhh1p/Me31B) pathways. Drosophila Me31B is shown to participate (1) with an FMRP-associated, P body protein (Scd6p/trailer hitch) in FMRP-driven, argonaute-dependent translational repression in developing eye imaginal discs; (2) in dendritic elaboration of larval sensory neurons; and (3) in bantam miRNA-mediated translational repression in wing imaginal discs. These results argue for a conserved mechanism of translational control critical to neuronal function and open up new experimental avenues for understanding the regulation of mRNA function within neurons. Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. SA Barbee PS Estes AM Cziko J Hillebrand RA Luedeman JM Coller N Johnson IC Howlett C Geng R Ueda AH Brand SF Newbury JE Wilhelm RB Levine A Nakamura R Parker M Ramaswami doi:10.1016/j.neuron.2006.10.028 Neuron, Vol. 52, No. 6. (21 December 2006), pp. 997-1009. 2007-04-16T10:28:13-00:00 2006 Neuron 0896-6273 52 6 997 1009 body fmrp neuronal p rnps staufen