Thu, 21 Aug 2008 15:36:20 BST CiteULike: lechristophe Newpher http://www.citeulike.org/user/lechristophe/author/Newpher CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/lechristophe/article/2868886 <i>Neuron, Vol. 58, No. 4. (22 May 2008), pp. 472-497.</i><br /><br />Among diverse factors regulating excitatory synaptic transmission, the abundance of postsynaptic glutamate receptors figures prominently in molecular memory and learning-related synaptic plasticity. To allow for both long-term maintenance of synaptic transmission and acute changes in synaptic strength, the relative rates of glutamate receptor insertion and removal must be tightly regulated. Interactions with scaffolding proteins control the targeting and signaling properties of glutamate receptors within the postsynaptic membrane. In addition, extrasynaptic receptor populations control the equilibrium of receptor exchange at synapses and activate distinct signaling pathways involved in plasticity. Here, we review recent findings that have shaped our current understanding of receptor mobility between synaptic and extrasynaptic compartments at glutamatergic synapses, focusing on AMPA and NMDA receptors. We also examine the cooperative relationship between intracellular trafficking and surface diffusion of glutamate receptors that underlies the expression of learning-related synaptic plasticity. Glutamate receptor dynamics in dendritic microdomains. TM Newpher MD Ehlers doi:10.1016/j.neuron.2008.04.030 Neuron, Vol. 58, No. 4. (22 May 2008), pp. 472-497. 2008-06-06T09:23:22-00:00 2008 Neuron 1097-4199 58 4 472 497 dendrites dendritic_spines endocytosis glur membrane_diffusion review http://www.citeulike.org/user/lechristophe/article/2108896 <i>Neuron, Vol. 55, No. 6. (20 September 2007), pp. 874-889.</i><br /><br />Summary Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis is thought to control spine composition and regulate synaptic transmission. However, the mechanisms that situate the EZ near the PSD and the role of spine endocytosis in synaptic transmission are unknown. Here, we report that a physical link between dynamin-3 and the postsynaptic adaptor Homer positions the EZ near the PSD. Disruption of dynamin-3 or its interaction with Homer uncouples the PSD from the EZ, resulting in synapses lacking postsynaptic clathrin. Loss of the EZ leads to a loss of synaptic AMPA receptors and reduced excitatory synaptic transmission that corresponds with impaired synaptic recycling. Thus, a physical link between the PSD and the EZ ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling AMPA receptors. Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer Jiuyi Lu Thomas Helton Thomas Blanpied Bence Racz Thomas Newpher Richard Weinberg Michael Ehlers doi:10.1016/j.neuron.2007.06.041 Neuron, Vol. 55, No. 6. (20 September 2007), pp. 874-889. 2007-12-13T23:42:15-00:00 2007 Neuron 55 6 874 889 ampar cultured_hippo_neurons dendritic_spines endocytosis synapse